Carotenoids as protectors against UVB induced cutaneous damage.

类胡萝卜素作为 UVB 引起的皮肤损伤的保护剂。

• 批准号: 8450747
• 负责人: TATIANA M OBERYSZYN
• 金额: $ 15.59万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8450747
• 关键词: Acute; Agriculture; American; Anti-Inflammatory Agents; Anti-inflammatory; Antioxidants; Basal cell carcinoma; Carotenoids; Chemopreventive Agent; Chronic; Clinical Investigator; Clinical Research; Collaborations; Consumption; Cutaneous; DNA Damage; Development; Diagnosis; Diet; Dietary Intervention; Disease; Dose; Ecology; Environmental Carcinogens; Epidemiologic Studies; Epidemiology; Female; Food; Freeze Drying; Gender; Human; Inbred HRS Mice; Inflammation; Inflammatory; Laboratories; Life Style; Malignant Neoplasms; Mediating; Mus; Ohio; Pathway interactions; Pre-Clinical Model; Property; Prostate; Reporting; Research; Risk; Sex Characteristics; Skin; Skin Cancer; Skin Carcinoma; Skin Neoplasms; Squamous cell carcinoma; Testing; The Sun; Time; Tomatoes; Translating; Tumor Promotion; UV induced; Ultraviolet Rays; United States; Universities; Woman; Work; base; cancer type; college; design; feeding; lycopene; male; men; phytoene; phytofluene; pre-clinical; prospective; response; sex; sun protection; tumor; tumor progression; ultraviolet; ultraviolet damage

DESCRIPTION (provided by applicant): Ultraviolet light B (UVB) is a major environmental carcinogen that has been implicated in the development of non-melanoma skin cancers (NMSC). These skin tumors are the most common form of cancer in humans, with over 1 million new cases identified in the United States each year. In fact, more Americans will be diagnosed with some form of skin cancer than all other cancers combined. Epidemiological studies have shown that there are gender differences in the development of NMSC, with men being twice as likely to develop Basal Cell Carcinoma (BCC)and three times as likely to develop squamous cell carcinoma (SCC) as women. Studies from our laboratory suggest that the pathways by which UV exerts its damaging effects in male and female skin are not the same and that blocking UV-induced inflammation in male skin may not be as effective in decreasing tumor development as we have shown it to be in female skin. Recent studies have described a correlation between tomato consumption and a decrease of a number of different cancers; however, the effects of tomato consumption on UVB-induced skin cancer development have not been evaluated. The studies in this application are designed to test the hypothesis that the dietary consumption of tomatoes containing the carotenoids lycopene, phytoene, or phytofluene will reduce skin damage caused by UV radiation as compared to no tomato consumption, ultimately resulting in decreased tumor development. We also hypothesize that there will be a dose-response relationship such that diets containing freeze dried tangerine tomato products containing high levels of phytoene and phytofluene will confer a greater level of protection against UV damage than red tomato products containing an intermediate level of these carotenoids. Furthermore, based on our preliminary studies, we hypothesize that there will be gender-dependent differences in the response to the tomato diets. Two specific aims are proposed. Specific aim 1 will determine whether the dietary consumption of phytoene, phytofluene, and lycopene in tangerine tomatoes and/or red tomatoes reduces the inflammatory and DNA-damaging effects of acute UVB exposure differentially in male and female Skh-1 murine skin. Studies in specific aim 2 will determine the differential chemopreventive effects of the dietary consumption of phytoene, phytofluene, and lycopene in tangerine tomatoes and red tomatoes on UVB-induced tumor promotion and progression in male and female Skh-1 murine skin. Ultimately, we hope to translate our pre-clinical findings to nutritional interventions in humans in collaboration with clinical investigators at OSU.

描述（由申请人提供）： 紫外线B（UVB）是一种主要的环境致癌物，与非黑色素瘤皮肤癌（NMSC）的发展有关。这些皮肤肿瘤是人类最常见的癌症形式，每年在美国确定超过100万例新病例。实际上，与所有其他癌症的综合相比，将被诊断出某种形式的皮肤癌。流行病学研究表明，NMSC的发展存在性别差异，男性发展基底细胞癌（BCC）的可能性是男性的两倍，而发展鳞状细胞癌（SCC）的可能性是女性的三倍。我们实验室的研究表明，紫外线在雄性和女性皮肤中发挥破坏性作用的途径并不相同，并且阻塞紫外线诱导的雄性皮肤炎症在降低肿瘤发育方面可能不如我们证明其在雌性皮肤中的有效性。最近的研究描述了番茄消耗与许多不同癌症的减少之间的相关性。但是，尚未评估番茄消耗对UVB诱导的皮肤癌发育的影响。该应用中的研究旨在检验以下假设：与没有西红柿消耗相比，含有类胡萝卜素番茄红素，植物或植物的西红柿会减少紫外线辐射造成的皮肤损伤，最终导致肿瘤降低。我们还假设将存在剂量反应关系，以便含有含有高水平的植物和植物氟苯的冻干橘子番茄产品的饮食将比含有这些类胡萝卜素中等水平的红色番茄产品提供更大的防紫外番茄损害损害。此外，根据我们的初步研究，我们假设对番茄饮食的反应会存在性别依赖性差异。提出了两个具体目标。具体的目标1将确定橘子西红柿中植物，植物氟苯和番茄红素的饮食消耗和/或红番茄是否会降低雄性和雌性SKH-1鼠皮的急性UVB暴露的炎症和DNA损害作用。在特定目标2中的研究将确定浓汤西红柿中植物，植物氟苯和番茄红素饮食的差异化化学预防作用，以及红番茄中的乳化性化学消费对UVB诱导的肿瘤促进和雄性和雌性SKH-1鼠类SKH-1鼠皮的进展。最终，我们希望通过与OSU的临床研究人员合作，将我们的临床前发现转化为人类营养干预措施。

项目成果

Sex differences in skin carotenoid deposition and acute UVB-induced skin damage in SKH-1 hairless mice after consumption of tangerine tomatoes.

食用橘子西红柿后 SKH-1 无毛小鼠皮肤类胡萝卜素沉积和急性 UVB 引起的皮肤损伤的性别差异。

• DOI: 10.1002/mnfr.201500317
• 发表时间: 2015
• 期刊: Molecular nutrition & food research
• 影响因子: 5.2
• 作者: Kopec,RachelE;Schick,Jonathan;Tober,KathleenL;Riedl,KenM;Francis,DavidM;Young,GregoryS;Schwartz,StevenJ;Oberyszyn,TatianaM
• 通讯作者: Oberyszyn,TatianaM