Imaging for Y90 Microscphere SIRT Planning

Y90 微球 SIRT 规划的成像

基本信息

批准号：
8269824
负责人：
Anthony J McGoron
金额：
$ 18.54万
依托单位：
FLORIDA INTERNATIONAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-06-01 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8269824
关键词：
90Y Albumins American Cancer Society Anatomy Angiography Animals Beta Particle Bile duct carcinoma Biocompatible Biodegradable microsphere Biodegradation Biodistribution Blood Vessels Blood specimen Bone Marrow Suppression Caliber Chelating Agents Chemicals Chemistry Chitosan Clinical Code Colorectal Colorectal Cancer Computer software Coupling Deposition Detection Developed Countries Diagnosis Discipline of Nuclear Medicine Dose Drug Delivery Systems Drug Formulations Elastomers Electron Microscope Emulsions Evaluation Future Glycerol Glycolates Goals Hepatic Hepatic artery Hour Image Imaging technology In Vitro Kidney Knowledge Label Left Liver Liver diseases Liver neoplasms Liver parenchyma Lung Malignant Neoplasms Malignant neoplasm of liver Malignant neoplasm of lung Malignant neoplasm of prostate Measurement Measures Medical Device Methods Microspheres Modeling Monitor Neoplasm Metastasis Neuroendocrine Tumors Organ failure Oryctolagus cuniculus Outcome Pancreas Patients Perfusion Phosphate Buffer Polyanhydrides Polymers Porosity Portal vein structure Primary Neoplasm Property Publishing Radiation Radiation therapy Radio Radioactive Radioisotopes Radiolabeled Radionuclide Imaging Radioprotection Rattus Research Risk Scanning Shapes Shunt Device Site Spleen Sprague-Dawley Rats Stomach Surface Survival Rate Technetium 99m Techniques Testing Therapeutic Therapeutic Effect Therapeutic Intervention Time Tissue Engineering Tissues United States Unresectable Vascular blood supply Visceral Work arteriole base biocompatible polymer biodegradable polymer density design dosimetry gastrointestinal improved in vivo internal radiation liver imaging malignant breast neoplasm meetings metastatic colorectal nano outcome forecast particle radiochemical radiotracer response scaffold treatment planning tumor uptake

项目摘要

DESCRIPTION (provided by applicant): Yttrium-90 (Y-90) microsphere radioembolization, known as Selective Internal Radiation Therapy (SIRT), via hepatic arterial administration is a treatment for patients with primary and metastatic liver cancer because the primary blood supply to liver tumors is from the hepatic artery while the majority of the blood supply to the normal liver is from the portal vein. The micro-vascular density of liver tumors is 3-200 times greater than the surrounding liver parenchyma further improving the selectivity of the therapy to the tumor. In this treatment, 30 5m diameter spheres labeled with the radioactive isotope Y-90 (a high-energy beta particle-emitting radioisotope) become lodged in the arterioles within the tumor and destroy the tumor while leaving the normal liver tissue mostly unharmed. For treatment planning Tc-99m-macro aggregated albumin (MAA) is infused into the proper hepatic artery and a perfusion scintigraphy is performed. However, the significant difference in size, shape, and other properties of the MAA and the Y-90 microspheres complicates the treatment planning because the MAA particles cannot be expected to distribute the same as the Y-90 microspheres. Thus it is desirable to develop and use a new biodegradable sphere for accurate SIRT planning. Nano and microparticles of biodegradable materials like Poly(lactic-co-glycolic acid) (PLGA), Polyanhydrides, and Chitosan, have been investigated widely for drug delivery. They have been shown to be both biocompatible and biodegradable. More recently, a new synthetic biodegradable elastomer Poly(glycerol Dodecanedioate) (PGD) has been developed for medical devices and tissue engineering scaffolds. These polymers will be used, employing different emulsion techniques, to produce approximately 30 5m size biodegradable microspheres to match the size and shape of the Y-90 microspheres used in the treatment. Once obtained, the different particles will be submitted to in vitro degradation studies in phosphate buffer and characterized with respect to shape, size, size distribution, surface roughness, and porosity using scanning electron microscope. Yttrium-90 (Y-90) microsphere radioembolization, known as Selective Internal Radiation Therapy (SIRT), via hepatic arterial administration is a treatment for patients with primary and metastatic liver cancer because the primary blood supply to liver tumors is from the hepatic artery while the majority of the blood supply to the normal liver is from the portal vein. The use of a specific chelator (coupling chemical) attached to the surface of the particles will also be evaluated for labeling yields, radiochemical purity and stability of the final product. The final step of the project is the in vivo evaluation of the particles; which will be evaluated in Sprague Dawley rats. The animals will be euthanized at different times and the samples of blood, lung, liver, kidney, and spleen will be collected for measuring of radioactive content in a gamma well counter. Numerical dosimetry calculations will be done to evaluate the radiation field and dose distributions and assure radioprotection standards are met.

描述（由申请人提供）：Yttrium-90（Y-90）微球栓塞，被称为选择性内部放射治疗（SIRT），通过肝动脉施用是一种治疗肝癌的原发性和转移性肝癌患者的治疗方法，因为肝动脉的原发性血液供应是肝动脉的原发性血液供应。肝肿瘤的微血管密度是周围肝实质的3-200倍，进一步提高了治疗对肿瘤的选择性。在这种处理中，用放射性同位素Y-90（高能量β颗粒发射放射性同位素）标记为30 5m直径球，并在肿瘤内的小动脉中浮动并破坏肿瘤，同时使正常的肝脏组织大多不受伤害。为了治疗计划，将TC-99M-MaCro聚集白蛋白（MAA）注入适当的肝动脉，并进行灌注闪烁显像。但是，MAA和Y-90微球的大小，形状和其他特性的显着差异使治疗计划变得复杂，因为不能期望MAA颗粒分布与Y-90微球相同。因此，希望开发和使用新的可生物降解领域进行准确的SIRT计划。已经广泛研究了用于药物递送的纳米和可生物降解材料（例如聚乳 - 乙醇酸），聚酸酯和壳聚糖等可生物降解材料。它们已被证明既具有生物相容性又可生物降解。最近，已经开发了一种用于医疗设备和组织工程支架的新型合成可生物降解弹性体聚（PGD）（PGD）。这些聚合物将使用不同的乳液技术使用，以生产约30 5M尺寸的可生物降解微球，以匹配处理中使用的Y-90微球的尺寸和形状。一旦获得，不同的颗粒将在磷酸盐缓冲液中的体外降解研究中提交，并在形状，尺寸，尺寸分布，表面粗糙度和使用扫描电子显微镜的孔隙率方面进行表征。 YTTRIUM-90（Y-90）微球放射性栓塞，称为选择性内部放射治疗（SIRT），通过肝动脉施用是一种治疗肝癌的原发性和转移性肝癌患者的治疗方法，因为肝肿瘤的原发性血液供应来自肝动脉，而对正常肝脏的血液供应主要是来自肝脏的正常肝脏。还将评估连接到颗粒表面的特定螯合剂（耦合化学物质）的使用，以获得最终产品的标记产率，放射化学纯度和稳定性。该项目的最后一步是对颗粒的体内评估。将在Sprague Dawley大鼠中进行评估。这些动物将在不同的时间安乐死，并将收集血液，肺，肝脏，肾脏和脾脏的样本，以测量伽马井计数器中的放射性含量。将完成数值剂量测定计算以评估辐射场和剂量分布，并确保放射线保护标准标准。