Autonomic Cardiovascular Regulation

心血管自主调节

基本信息

批准号：
8268649
负责人：
DAVID HERLIE ROBERTSON
金额：
$ 183.14万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-08-01 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8268649
关键词：
Address Adenosine Adopted Adrenal Cortex Hormones Adrenergic Receptor Affect American Antihypertensive Agents Area Arrhythmia Autonomic Dysfunction Autonomic nervous system Autonomic nervous system disorders Basic Science Biochemical Biomedical Research Blood Glucose Blood Platelets Blood Pressure Blood Vessels Bradycardia Brain Cardiac Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Center for Translational Science Activities Clinic Clinical Clinical Management Clinical Pharmacology Clinical Research Clinical Sciences Collaborations Complex Controlled Study Data Databases Development Diabetes Mellitus Discipline Disease Doctor of Medicine Doctor of Philosophy Dysautonomias Educational process of instructing Endocrine Ensure Equilibrium Exercise Failure Fostering Functional disorder Gender Genetic Genetic Predisposition to Disease Glucose Goals Grant Health Heart Hereditary Disease Hormones Human Hyperglycemia Hypertension Hypoglycemia In Vitro Individual Ingestion Insulin International Japanese Population Journals Knowledge Laboratories Lead Leadership Link Maryland Mediating Mediator of activation protein Medicine Metabolic Metabolic stress Metabolism Methodology Microgravity Mission Morbidity - disease rate Myocardial Infarction National Heart, Lung, and Blood Institute Nature Neurology Neurosciences Neurosecretory Systems Newsletter Nitric Oxide Norepinephrine Obesity Participant Pathway interactions Patients Peripheral Pharmacoepidemiology Pharmacogenetics Pharmacology Phenotype Physicians Physiological Physiology Positioning Attribute Principal Investigator Process Productivity Program Research Project Grants Rare Diseases Recording of previous events Records Regulation Renin Research Research Personnel Resources Role Scientist Seminal Series Societies Source Stress Stroke Sudden Death Sympathetic Nervous System Syncope Syndrome Testing Therapeutic Tissues Training Training Programs Translating Translational Research United States United States National Institutes of Health Universities Ursidae Family Variant Visit Water Work adrenal hypertension beta-adrenergic receptor blood glucose regulation blood pressure regulation cardiovascular risk factor clinical effect design experience flexibility human disease human subject improved in vivo interest meetings member mortality multidisciplinary patient oriented patient oriented research professor programs psychologic research study response skills sugar

项目摘要

DESCRIPTION (provided by applicant): The autonomic nervous system is the crucial link between the brain and the cardiovascular system. It is the final common pathway by which central disturbances - whether initiated by exogenous psychological or physical stress, or endogenous biochemical or structural perturbation - are translated into alterations in cardiac, endocrine, and vascular function. There is compelling evidence that disordered autonomic engagement of the heart and vasculature contributes importantly to many forms of cardiovascular disease: arrhythmias, hypertension, syncope, stroke, myocardial infarction, and sudden death. The goal of this Program Project is to achieve better understanding of how the brain exerts control over the autonomic nervous system. The integrating of the grant is autonomic cardiovascular regulation and the means by which the autonomic nervous system controls effector tissues. The rationale of the Program Project is the tightly coordinated testing of hypotheses addressing autonomic modulation of cardiovascular function in health and disease. Component projects address central and peripheral autonomic mechanisms, employing both integrated and reductionist approaches. The roles of specific body constituents (insulin, hormones, adrenoreceptors), endogenous mediators (nitric oxide, water), and afferent (osmopressor response), efferent (obesity hypertension), and endocrine (hypoglycemia, exercise, and hyperglycemia) mechanisms are examined. The programmatic approach facilitates the bidirectional transfer of information between the laboratory and the clinic because it brings together investigators with a wide range of skills who have a track record of discovering new fundamental knowledge and applying it to the creation of practical improvements in human health. This Program Project should lead directly to improved therapy in cardiovascular disease.

描述（由申请人提供）：自主神经系统是大脑与心血管系统之间的关键联系。这是最终的常见途径，无论是通过外源心理或身体压力引发的中心干扰，还是内源性生化或结构扰动 - 都会转化为心脏，内分泌和血管功能的改变。有令人信服的证据表明，心脏和脉管系统的自主性参与无序对许多形式的心血管疾病重要贡献：心律不齐，高血压，晕厥，中风，心肌梗塞和猝死。该计划项目的目标是更好地了解大脑对自主神经系统的控制。赠款的整合是自主性心血管调节，以及自主神经系统控制效应组织的手段。该计划项目的基本原理是对假设的严格协调测试，该假设解决了健康和疾病中心血管功能的自主神经调节。组件项目采用综合和还原主义方法，解决中央和外围自主机制。特定身体成分（胰岛素，激素，肾上腺受体），内源性介质（一氧化物，水）和传入（Osmopressor反应），屈服（肥胖性高血压）和内分泌（降低性糖类，运动，运动和高血糖）的作用。程序化方法促进了实验室和诊所之间信息的双向传输，因为它汇集了具有广泛技能的调查员，他们有发现的记录新的基本知识并将其应用于人类健康的实际改进。该计划项目应直接导致改善心血管疾病的治疗。