Improved Batteries for Implantable Cardiac Defibrillators

改进的植入式心脏除颤器电池

基本信息

批准号：
8509074
负责人：
Amy Catherine Marschilok
金额：
$ 18.64万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-12-15 至 2014-11-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): There is an ever growing demand for implantable cardiac defibrillators (ICDs), with over 100,000 devices implanted in 2004, and dramatic increases anticipated over the next decade due to expanded indications and coverage by Medicare. The growing level of acceptance of these lives- saving devices has increased the desire for improved ICD function. The lifetime of the average ICD patient after implant has increased to 10 years while the average device lifetime is around 5 years. Thus, most patients require additional surgeries to replace their original device, resulting in both clinical risk and cost. The current benchmark power source technology is lithium/silver vanadium oxide (Li/SVO) developed >20 years ago. Li/SVO battery technology can display a significant midlife decrease in performance termed voltage delay. This voltage delay, a result of cathode solubility and the associated formation of a passivation film on the anode, has caused premature device explants for numerous patients at the 2.5 to 3 year point due to delays in therapy delivery. Along with the added expense of the unplanned surgery, premature device explant can create patient anxiety. Options employed to `work around' Li/SVO voltage delay lead to shortened battery life. The overall project goal is to solve this problem with fundamental science by demonstrating new superior cathode materials that could be used to extend the life and improve the consistency of ICD batteries. The proposed project has three specific objectives: 1) develop a new class of improved battery materials for ICD applications based on metal-metal-phosphorous-oxides of the MwM'xPyOz (MM'PO) family (M = silver or copper; M' = vanadium or iron), 2) test the materials in experimental batteries under simulated use schemes mimicking ICD function, and 3) compare the key characteristics of long term stability (lack of solubility and voltage delay), energy delivery, and energy content with the current battery benchmark technology (Li/SVO). The proposed activity involves the synthesis, characterization and electrochemistry of a new family of materials, MM'POs. We hypothesize that MM'POs will have improved ICD battery performance based on their fundamental chemical properties: reduced solubility of phosphate based materials compared to analogous oxide compounds, high voltage of vanadium or iron compounds yielding high levels of energy delivery, and the inclusion of silver or copper ions in the matrix to provide high volumetric energy content. PUBLIC HEALTH RELEVANCE: Implantable cardiac defibrillators (ICDs) are lifesaving devices which monitor and correct abnormal heart rhythms and have become an increasingly accepted treatment option. The project goal is to create a new class of materials (MM'POs) and demonstrate their superiority to the current benchmark cathode materials for ICD batteries. Ultimately, our MM'POs will extend the life and improve the consistency of ICD batteries, reducing the frequency of device replacements and the associated negative impact on patients and healthcare costs.

描述（由申请人提供）：对可植入的心脏除颤器（ICD）的需求越来越不断增长，2004年植入了100,000多个设备，并且由于Medicare的迹象和覆盖范围扩大，未来十年的预期会在未来十年内发生急剧增长。这些救生设备的接受程度不断提高，这增加了对ICD功能改善的愿望。植入物后普通ICD患者的寿命已增加到10年，而平均设备寿命约为5年。因此，大多数患者需要额外的手术来替换其原始设备，从而导致临床风险和成本。当前的基准电源技术是20年前开发的锂/氧化锂（LI/SVO）。 LI/SVO电池技术可以显示出所谓的电压延迟的性能降低。这种电压延迟是阴极溶解度的结果以及在阳极上相关的钝化膜的相关形成，由于治疗递延的延迟，在2.5至3年的时间内为众多患者造成了过早的装置外植体。除了计划外科手术的额外费用外，过早的设备外观可以引起患者焦虑。用来“围绕” li/svo电压延迟而采用的选项会导致电池寿命缩短。总体项目目标是通过展示可用于延长寿命并提高ICD电池一致性的新的上级阴极材料来解决基本科学的问题。拟议的项目具有三个具体目标：1）基于MWM'XPYOZ（MM'PO）家族的金属金属磷酸氧化物（M =银或铜; M = Silver or; M'= Vanadium; M'=钒或铁）开发一类新的电池材料，以使用Mimick ICD的特征和3）测试，2）当前电池基准技术（LI/SVO），溶解度和电压延迟），能量输送和能量含量。提出的活动涉及新材料家族MM'POS的合成，表征和电化学。我们假设MM'POS会根据其基本化学性能改善ICD电池的性能：与类似的氧化物化合物相比，基于磷酸盐的材料的溶解度降低，钒化合物的高压或铁化合物产生高水平的能量输送水平，以及在基质中含有高燃料能量的能量含量的含量。公共卫生相关性：可植入的心脏除颤器（ICD）是救生设备，可以监测和纠正异常心律，并已成为越来越接受的治疗选择。项目的目标是创建新的材料（MM'POS），并证明它们优于当前用于ICD电池的基准阴极材料。最终，我们的MM'POS将延长寿命并提高ICD电池的一致性，降低设备更换的频率以及对患者和医疗保健成本的相关负面影响。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Silver Vanadium Phosphorous Oxide, Ag(2)VO(2)PO(4): Chimie Douce Preparation and Resulting Lithium Cell Electrochemistry.

DOI：
10.1016/j.jpowsour.2010.10.054
发表时间：
2011-08-15
期刊：
JOURNAL OF POWER SOURCES
影响因子：
9.2
作者：
Kim, Young Jin;Marschilok, Amy C.;Takeuchi, Kenneth J.;Takeuchi, Esther S.
通讯作者：
Takeuchi, Esther S.

Silver vanadium oxide and silver vanadium phosphorous oxide dissolution kinetics: a mechanistic study with possible impact on future ICD battery lifetimes.

DOI：
10.1039/c3dt51544c
发表时间：
2013-09
期刊：
Dalton transactions
影响因子：
4
作者：
D. Bock;K. Takeuchi;A. Marschilok;E. Takeuchi
通讯作者：
D. Bock;K. Takeuchi;A. Marschilok;E. Takeuchi

A Kinetics and Equilibrium Study of Vanadium Dissolution from Vanadium Oxides and Phosphates in Battery Electrolytes: Possible Impacts on ICD Battery Performance.

DOI：
10.1016/j.jpowsour.2013.01.012
发表时间：
2013-06-01
期刊：
JOURNAL OF POWER SOURCES
影响因子：
9.2
作者：
Bock, David C.;Marschilok, Amy C.;Takeuchi, Kenneth J.;Takeuchi, Esther S.
通讯作者：
Takeuchi, Esther S.

Synthetic control of composition and crystallite size of silver hollandite, Ag(x)Mn8O16: impact on electrochemistry.

DOI：
10.1021/am301443g
发表时间：
2012-10-24
期刊：
ACS APPLIED MATERIALS & INTERFACES
影响因子：
9.5
作者：
Takeuchi, Kenneth J.;Yau, Shali Z.;Menard, Melissa C.;Marschilok, Amy C.;Takeuchi, Esther S.
通讯作者：
Takeuchi, Esther S.

Electrochemical Reduction of Silver Vanadium Phosphorous Oxide, Ag(2)VO(2)PO(4): Silver Metal Deposition and Associated Increase in Electrical Conductivity.