Stress, Coping, Health, & Optimal Aging

压力、应对、健康、

基本信息

批准号：
8286439
负责人：
CAROLYN M. ALDWIN
金额：
$ 4万
依托单位：
OREGON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8286439
关键词：
21 year old Address Adult Adverse effects Affect Age Aging American Amylases Attenuated Biological Markers Blood Pressure Buffers Cardiovascular Diseases Cholesterol Chronic Chronic stress Circadian Rhythms Coronary heart disease Coupling Data Data Collection Development Disease Disease Outcome Distal Economics Elderly Epidemiologic Studies Equilibrium Event First Independent Research Support and Transition Awards Funding Future Gender Growth Health Healthcare High Density Lipoproteins Hydrocortisone Hypertension Incidence Individual Individual Differences Informal Social Control Laboratories Life Life Stress Link Literature Longevity Longitudinal Studies Low-Density Lipoproteins Maintenance Measures Medical Mental Health Modeling Neurotic Disorders Older Population Outcome Patient Self-Report Pattern Personal Satisfaction Personality Physiological Physiology Principal Investigator Process Psychosocial Factor Public Health Recovery Reporting Research Resources Rest Risk Salivary Sampling Services Sex Characteristics Shapes Stress Stress and Coping Symptoms Testing Theoretical model Time Wife Woman age difference age related alpha-amylase body-mind cohort coping cost design diaries men middle age mind body interaction mortality older men older women optimism physical conditioning programs psychologic public health relevance stress management stressor

项目摘要

DESCRIPTION (provided by applicant): Stress and coping processes affect biomarkers such as blood pressure, cholesterol fractions, and cortisol in laboratory settings, and self-reported health in field settings. However, establishing the stress-illness link has been very difficult (Cohen et al., 2007), in part because many epidemiological studies of stress have single measures of life events which, at best, are only weak predictors of long-term health. At the Normative Aging Study, we have been collecting stress and coping data for 20+ years, which provides a unique opportunity to examine how patterns of stress over the long term (e.g., chronic vs. intermittent vs. low) affect changes in biomarkers, the development of cardiovascular disease, and mortality, as well as long-term mental health trajectories. Our theoretical model proposes that individuals can decrease vulnerability to disease and promote optimal aging through judicious management of stress, including appraisal and coping processes. The Normative Aging Study (NAS) is a large panel study of 2,280 men aged 21 to 80 at study onset in the 1960s. In 1985, we began studying life events, and in 1989 began collecting, life events, hassles and coping measures in conjunction with the triennial biomedical exams. In 2001, we added daily stressors using diary studies, and included NAS wives. In 2008 we added cortisol to the daily diary studies. The proposed additional data collection in the NAS will allow us to utilize a longitudinal burst design to examine the interplay among chronic stress, daily stress, personality, and biomarkers such as cortisol diurnal rhythms and alpha amylase in older men and women. We will also examine change in cortisol reactivity over time, thought to be a key factor modulating the rate of aging. The first specific aim will be to model patterns of change in stress and coping processes from middle-age to late life, using growth mixture models. Second, we will examine the impact of these different patterns on changes in biomarkers (e.g., blood pressure, cholesterol fractions), as well as the development of cardiovascular disease and mortality. Using coupling analyses, we hypothesize that hassles will better predict change in the more proximal biomarkers, while life event patterns will be better predictors of long-term health outcomes. In contrast, positive coping will promote the maintenance of good mental health as well as HDL levels. The third specific aim will examine the impact of chronic stress, personality, gender, and aging on cortisol reactivity. PUBLIC HEALTH RELEVANCE: The older population of Americans, age 65+, is expected to almost double by 2040. As older adults are by far the largest consumers of medical services, this threatens an economic and public health care crisis in the near future. Understanding the psychosocial factors that promote optimal aging may help to attenuate these costs.

描述（由申请人提供）：压力和应对过程会影响实验室环境中的生物标志物，例如血压、胆固醇分数和皮质醇，以及现场环境中自我报告的健康状况。然而，建立压力与疾病之间的联系非常困难（Cohen et al., 2007），部分原因是许多压力流行病学研究对生活事件进行了单一测量，而这些测量充其量只能作为长期健康的微弱预测指标。在规范老龄化研究中，我们已经收集了 20 多年的压力和应对数据，这提供了一个独特的机会来研究长期压力模式（例如，慢性、间歇性、低度）如何影响生物标志物的变化，心血管疾病的发展和死亡率，以及长期的心理健康轨迹。我们的理论模型提出，个人可以通过明智的压力管理（包括评估和应对过程）来降低对疾病的脆弱性并促进最佳衰老。规范老龄化研究 (NAS) 是一项大型小组研究，研究对象为 2,280 名年龄在 21 岁至 80 岁之间的男性，研究始于 20 世纪 60 年代。 1985年，我们开始研究生活事件，并于1989年开始结合三年一次的生物医学检查收集生活事件、麻烦和应对措施。 2001 年，我们通过日记研究添加了日常压力源，并将 NAS 的妻子纳入其中。 2008 年，我们将皮质醇添加到每日日记研究中。 NAS 中拟议的额外数据收集将使我们能够利用纵向突发设计来检查老年男性和女性的慢性压力、日常压力、个性和生物标志物（如皮质醇昼夜节律和 α 淀粉酶）之间的相互作用。我们还将检查皮质醇反应性随时间的变化，这被认为是调节衰老速度的关键因素。第一个具体目标是使用生长混合模型来模拟从中年到晚年的压力和应对过程的变化模式。其次，我们将研究这些不同模式对生物标志物（例如血压、胆固醇分数）变化以及心血管疾病和死亡率发展的影响。通过耦合分析，我们假设麻烦将更好地预测更近端生物标志物的变化，而生活事件模式将更好地预测长期健康结果。相反，积极应对将促进保持良好的心理健康以及高密度脂蛋白水平。第三个具体目标将研究慢性压力、性格、性别和衰老对皮质醇反应性的影响。公共卫生相关性：到 2040 年，65 岁以上的美国老年人口预计将几乎翻一番。由于老年人是迄今为止最大的医疗服务消费者，这可能会在不久的将来引发经济和公共卫生危机。了解促进最佳衰老的社会心理因素可能有助于减轻这些成本。