Clinical and Translational

临床和转化

基本信息

批准号：
8380286
负责人：
ANDREW GOLDBERG
金额：
$ 26.6万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8380286
关键词：
African American American Amish Area Back Basic Science Behavior Therapy Biological Assay Biometry Blood flow Body Composition Body Weight decreased Body fat Bone Density Caloric Restriction Cardiovascular Physiology Chronic Clinical Clinical Nutrition Clinical Research Clinical Research Protocols Clinical Trials Collaborations Collection Communication Communities Comorbidity Conduct Clinical Trials Consultations Cost Effectiveness Analysis DNA Data Databases Development Diet Dietary Assessment Disease Drug Formulations Eating Educational process of instructing Endocrine Energy Intake Enrollment Environment Evaluation Exercise Exercise Physiology Exercise stress test Experimental Designs Faculty Fatty acid glycerol esters Focus Groups Fostering Genes Genetic Goals Habits Health system Hepatic Hormones Inflammatory Informatics Institutional Review Boards Insulin Interdisciplinary Study Intervention Intramuscular Investigation Knowledge Laboratories Laboratory Research Leadership Link Lipids Measures Mediating Medical Medical History Medical Informatics Metabolic Metabolism Methodology Minerals Mission Mitochondria Modality Molecular Genetics Molecular Probes Morbidity - disease rate Nitrogen Non-Insulin-Dependent Diabetes Mellitus Nutrient Nutritional Nutritional Study Obesity Obesity associated disease Outcome Participant Patient Selection Patients Peer Review Grants Pharmacological Treatment Phenotype Physical activity Plasma Play Postdoctoral Fellow Predisposition Preparation Prevalence Prevention approach Preventive Productivity Quality Control Registries Renal function Research Research Design Research Personnel Research Subjects Research Training Resources Role Sampling Science Screening procedure Seminal Services Students Study Subject Technology Testing Tissues Training Translating Translational Research Translations United States National Institutes of Health Visceral Work adipocyte biology base bench to bedside bone brachial artery cost effective cytokine data management diet and exercise dietary restriction efficacy testing evidence base experience follow-up frailty genetic registry glucose tolerance health disparity improved insight insulin sensitivity liver function meetings member mortality multidisciplinary muscle metabolism new technology novel strategies nutrition nutritional genomics obesity treatment organizational structure patient oriented patient oriented research patient registry prevent programs research study skills therapy design therapy development

项目摘要

The CTR Core serves as the central Mid-Atlantic NORC resource to facilitate the conduct of clinical research in nutrition and physical activity, seminal areas of investigation necessary to promote changes in the obesogenic American environment that will reduce the prevalence and ultimately prevent obesity. The multidisciplinary skills of the CTR Core's leadership assist Mid-Atlantic NORC investigators with study design, utilization of the wide range of state-of-the-art obesity, nutritional, metabolic and CVD-related research tests and interventions, and the development of collaborations. We promote the bi-directional translation of research from clinical experiences to the identification of genes that influence susceptibility to obesity and associated comorbidities in the Molecular Genetics and Nutrigenomics Core (MGN Core), and then probe the molecular and cellular mechanisms of obesity, type 2 diabetes and associated diseases in the Adipocyte Biology and Basic Mechanisms Core (ABBM Core) (Figure 1). We then assist investigators in the phenotyping of subjects, cardiometobolic evaluations, and the development and implementation of evidence-based diet, exercise and pharmacological interventions that can be translated into clinical trials in the community, and disseminated as real worid outcomes into practice (Figure 2).

CTR 核心作为中大西洋 NORC 的中央资源，促进营养和身体活动方面临床研究的开展，这些研究领域是推动美国肥胖环境发生变化所必需的重要研究领域，从而降低肥胖患病率并最终预防肥胖。 CTR 核心领导层的多学科技能可协助中大西洋 NORC 研究人员进行研究设计、利用各种最先进的肥胖、营养、代谢和 CVD 相关研究测试和干预措施，以及开展合作。我们在分子遗传学和营养基因组学核心（MGN 核心）中促进研究从临床经验到识别影响肥胖易感性和相关合并症的基因的双向转化，然后探讨 2 型肥胖的分子和细胞机制脂肪细胞生物学和基本机制核心（ABBM 核心）中的糖尿病及相关疾病（图 1）。然后，我们协助研究人员对受试者进行表型分析、心脏代谢评估，以及开发和实施基于证据的饮食、运动和药物干预措施，这些干预措施可以转化为社区的临床试验，并作为真实的结果传播到实践中（图 2））。