Global Network for Women's & Children's Health Research Data Coordinating Center

全球妇女网络

• 批准号: 8317375
• 负责人: Elizabeth M McClure
• 金额: $ 206.3万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-17 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8317375
• 关键词: Address; Adrenal Cortex Hormones; Caring; Child; Child health care; Childhood; Clinical Trials Data Monitoring Committees; Collaborations; Communication; Computer software; Computers; Country; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Quality; Developing Countries; Development; Discipline of obstetrics; Emergency Situation; Ensure; Environment; Equipment; Equipment and Supplies; Ethical Issues; Exhibits; Foundations; Funding; Funding Agency; Goals; Health; Human Development; Information Systems; Institutes; International; Internet; Leadership; Learning; Low income; Mails; Manuscripts; Maps; Minority; Mission; Monitor; Morbidity - disease rate; Multi-Institutional Clinical Trial; National Institute of Child Health and Human Development; Neonatal; Newborn Infant; Participant; Performance; Pharmaceutical Preparations; Productivity; Protocols documentation; Public Health; Publications; Publishing; Randomized; Real-Time Systems; Recording of previous events; Recruitment Activity; Registries; Reporting; Research; Research Design; Research Personnel; Resolution; Resources; Safety; Secure; Services; Site; Solutions; System; Telephone; Time; Training; Woman; Women' s Health; clinically relevant; data management; design; distributed data; drug distribution; editorial; experience; flexibility; human subject protection; improved; innovation; meetings; member; mortality; operation; public health relevance; rural area; social; sound; symposium; tool; transmission process; web site

DESCRIPTION (provided by applicant): RTI International (RTI), as the proposed data coordinating center (DCC) for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Global Network (GN), will provide the scientific and operational resources to maximize the scientific productivity and public health impact of the GN research collaborations across diverse research settings in multiple low-income countries. To achieve this aim, RTI will (1) provide scientific and statistical leadership to facilitate feasible, scientificaly sound, and clinically relevant protocols; (2) develop and support innovative, robust, secure, and locally sustainable data management systems (DMSs) that enhance the implementation of the study protocols and increase local research capacity; (3) develop effective data monitoring and safety reports that facilitate study management and oversight; (4) facilitate collaborative, high-quality GN study publications through rigorous analyses and logistical and editorial support; (5) coordinate the acquisition, storage, and tracking of study drugs, equipment, and supplies; and (6) promote efficient study development and implementation through logistical communication support of the GN protocol teams and the External Advisory Board and the Data Safety and Monitoring Board. RTI brings specific strengths that will support the GN's mission to enhance the global research capacity to improve health of women and children in low-income countries: (1) proven scientific collaboration in the leadership of the GN over the past 11 years as demonstrated by the more than 110 collaborative GN manuscripts and the collaboration of E. McClure in extending GN capacity through collaboration with external funding sources; (2) a set of state-of-the art, flexible, established distributed data entry and management tools that will (a ensure high-quality data with rapid error resolution, (b) provide creative solutions to difficult problems like drug distribution in rural areas, and (c) provide site staff with study management and reporting tools that enhance the scientific quality; and (3) statistical expertise in study design that has provided the GN with innovative cluster- and individually randomized designs and quality improvement approaches that address the unique scientific, implementation, cultural, and ethical issues encountered by the GN. Public Health Relevance: The Global Network for Women's and Children's Health Research (GN) is a multi-country research network developed to conduct research to identify solutions to reduce important causes of maternal and childhood mortality in developing countries. As the data coordinating center (DCC), RTI will provide the scientific and operational resources to maximize the scientific productivity and public health impact of the GN research collaborations by ensuring sound study design, high-quality data collection and analyses, and efficient communication across these diverse research settings.

描述（由申请人提供）：RTI International（RTI），作为Eunice Kennedy Shriver国家儿童健康与人类发展研究所（NICHD）全球网络（GN）的拟议数据协调中心（DCC），将提供科学和运营的资源，以最大程度地利用GN研究协作的科学生产力和公共卫生的影响。为了实现这一目标，RTI将（1）提供科学和统计的领导力，以促进可行的，科学的声音和临床相关的协议； （2）开发和支持创新，健壮，安全和本地可持续的数据管理系统（DMS），以增强研究协议的实施并提高本地研究能力； （3）制定有效的数据监控和安全报告，以促进研究管理和监督； （4）通过严格的分析以及后勤和社论支持来促进合作，高质量的GN研究出版物； （5）协调研究药物，设备和用品的获取，存储和跟踪； （6）通过GN协议团队和外部顾问委员会以及数据安全和监测委员会的后勤沟通支持来促进有效的研究开发和实施。 RTI带来了特定的优势，这些优势将支持GN提高全球研究能力，以改善低收入国家的妇女和儿童的健康：（1）在过去11年中，在GN领导中的科学合作证明了110多个合作GN手稿以及通过与外部富有慈善的富有富裕的GN能力扩展GN能力的合作; （2）一组最先进的艺术，灵活的，已建立的分布数据输入和管理工具（确保具有快速误差解决的高质量数据，（b）为困难问题提供了创造性的解决方案，例如农村地区的药物分布，（c）为现场工作人员提供研究管理和报告工具，以增强科学质量和（3）具有进化设计的统计设计；以及（3）具有统计学的统计设计； GN遇到的独特科学，实施，文化和道德问题。 公共卫生相关性：全球妇女和儿童健康研究网络（GN）是一个多国研究网络，开发了研究，以确定解决发展中国家孕产妇和儿童死亡率的重要原因的解决方案。作为数据协调中心（DCC），RTI将提供科学和运营的资源，以确保声音研究设计，高质量的数据收集和分析以及在这些多样化的研究环境中的有效沟通，从而最大程度地提高GN研究合作的科学生产力和公共卫生影响。