Role for B-cell mediated olfactory loss in Chronic Sinusitis with Nasal Polyps
B 细胞介导的嗅觉丧失在慢性鼻窦炎伴鼻息肉中的作用
基本信息
- 批准号:8225845
- 负责人:
- 金额:$ 22.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-12-15 至 2016-11-30
- 项目状态:已结题
- 来源:
- 关键词:AccountingAffectAnatomyAntigensAutoantibodiesAutoimmune ProcessAutoimmunityAutomobile DrivingAwardB-Cell ActivationB-LymphocytesBiological AssayBiometryBlood VesselsCell MaturationChronic SinusitisClinicalColorComplementDataDepositionDevelopmentDiagnostic testsDiseaseDrug or chemical Tissue DistributionEnzyme-Linked Immunosorbent AssayEpithelialEpitheliumEquipment and supply inventoriesFibroblastsFlow CytometryFunctional disorderFutureGenerationsGrantHead and Neck SurgeryHistological TechniquesIL6 geneImmunofluorescence ImmunologicImmunoglobulin AImmunoglobulin Class SwitchingImmunoglobulin GImmunologyImpairmentInferior nasal conchaInfiltrationInflammationInflammatoryInvestigationIrrigationK-Series Research Career ProgramsLaboratoriesMS4A1 geneMediatingMedicalMentorsMentorshipMolecularNasal PolypsNasal turbinate bone structureNeuronsNoseOlfactory MucosaOperative Surgical ProceduresOtolaryngologyPathogenesisPathogenicityPatientsPlasma CellsPlatelet-Derived Growth Factor ReceptorPlayPopulationRecoveryRegression AnalysisResearch DesignResearch PersonnelResistanceRisk FactorsRoleSerumSinusSmell PerceptionStructure of mucous membrane of noseSymptomsTestingTherapeuticTherapeutic AgentsTimeTissuesTrainingUniversitiesage relatedbasecareerchemokinechronic rhinosinusitisclinical practicecytokinedensityeosinophilimprovedmedical schoolsmolecular markermouse modelneuron lossolfactory thresholdoverexpressionplasma cell differentiationprofessor
项目摘要
DESCRIPTION (provided by applicant): Dr. Bruce K. Tan is an Assistant Professor in the Department of Otolaryngology-Head and Neck Surgery at the Northwestern University Feinberg School of Medicine where his clinical practice is dedicated to rhinolology and olfactory loss. This career development award, under the mentorship of Drs. Robert P. Schleimer and Jay A. Gottfried, is focused on understanding the impact of B-cell mediated inflammation on the pathogenesis and olfactory loss associated with Chronic Sinusitis with Nasal Polyps (CRSwNP). CRSwNP is a prevalent inflammatory condition of the nose and paranasal sinuses that is a major cause of acquired olfactory loss. Currently, the inflammatory mechanisms driving this disease are poorly understood, thus limiting the classes of therapeutic agents utilized to treat this disease. We have increasing evidence and further preliminary data showing that B-cell inflammation and autoimmunity is present within some nasal polyps and may play an important role in the persistent inflammation associated with CRSwNP. The candidate is proposing two non-overlapping, but complementary, aims that seek to understand the role for B-cell mediated inflammation in olfactory loss in CRSwNP. In Aim 1, the candidate will utilize a set of superior turbinate tissue from CRSwNP patients and normal controls to evaluate the impact of B-cell inflammation in olfactory tissue. In Aim 2, he will establish if the autoantibodies found in CRSwNP are associated with molecular markers of pathogenicity and clinical evidence for persistent inflammation and olfactory loss following surgical therapy. During this award, Dr. Tan will also acquire practical training and coursework in immunology, biostatistics and study design. This training and the data generated though the proposed aims will form the basis for the candidate's future career as an independent investigator.
PUBLIC HEALTH RELEVANCE: Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a major cause of smell loss. The mechanisms driving inflammation in this disease are poorly understood and result in limited treatments in this disease. We have recently discovered that B-cell inflammation and autoimmunity are active in the noses of patients with CRSwNP and these studies aim to assess the impact of these forms of inflammation on smell loss.
描述(由申请人提供):Bruce K. Tan博士是西北大学Feinberg医学院耳鼻喉科和颈部手术系的助理教授,在那里他的临床实践致力于隆旋学和嗅觉损失。在Drs的指导下,该职业发展奖。罗伯特·施莱默(Robert P. Schleimer)和杰伊·戈特弗里德(Jay A. CRSWNP是一种普遍的鼻子和副鼻窦炎症状态,是获得嗅觉损失的主要原因。当前,驱动这种疾病的炎症机制知之甚少,因此限制了用于治疗该疾病的治疗剂的类别。我们有越来越多的证据,进一步的初步数据表明,在某些鼻息肉中存在B细胞炎症和自身免疫性,并且可能在与CRSWNP相关的持续性炎症中起重要作用。 候选人提出了两个非重叠但互补的目标,目的是试图了解B细胞介导的炎症在CRSWNP中嗅觉损失中的作用。 在AIM 1中,候选人将利用CRSWNP患者和正常对照组的一组上涡轮组织组织来评估B细胞炎症在嗅觉组织中的影响。 在AIM 2中,他将确定CRSWNP中发现的自身抗体是否与致病性的分子标记和手术治疗后持续的炎症和嗅觉损失有关。在此奖项期间,TAN博士还将获得免疫学,生物统计学和研究设计的实践培训和课程。尽管拟议的目标将构成候选人作为独立研究者未来职业的基础,但该培训和生成的数据将构成。
公共卫生相关性:与鼻息肉(CRSWNP)的慢性鼻塞炎是闻起来丧失的主要原因。该疾病中驱动炎症的机制知之甚少,并导致这种疾病的治疗有限。 我们最近发现,B细胞炎症和自身免疫性在CRSWNP患者的鼻子中活跃,这些研究旨在评估这些形式的炎症对气味丧失的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Bruce K Tan其他文献
Bruce K Tan的其他文献
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{{ truncateString('Bruce K Tan', 18)}}的其他基金
Type-2 inflammation mediates olfactory loss in Chronic Rhinosinusitis: mechanisms and therapeutic opportunities
2 型炎症介导慢性鼻窦炎的嗅觉丧失:机制和治疗机会
- 批准号:
10219804 - 财政年份:2018
- 资助金额:
$ 22.88万 - 项目类别:
Autoantibody mediated pathogenesis in chronic rhinosinusitis with nasal polyps: mechanisms and consequences
自身抗体介导的慢性鼻窦炎伴鼻息肉的发病机制:机制和后果
- 批准号:
9903228 - 财政年份:2018
- 资助金额:
$ 22.88万 - 项目类别:
Autoantibody mediated pathogenesis in chronic rhinosinusitis with nasal polyps: mechanisms and consequences
自身抗体介导的慢性鼻窦炎伴鼻息肉的发病机制:机制和后果
- 批准号:
10388102 - 财政年份:2018
- 资助金额:
$ 22.88万 - 项目类别:
Type-2 inflammation mediates olfactory loss in Chronic Rhinosinusitis: mechanisms and therapeutic opportunities
2 型炎症介导慢性鼻窦炎的嗅觉丧失:机制和治疗机会
- 批准号:
10417217 - 财政年份:2018
- 资助金额:
$ 22.88万 - 项目类别:
Role for B-cell mediated olfactory loss in Chronic Sinusitis with Nasal Polyps
B 细胞介导的嗅觉丧失在慢性鼻窦炎伴鼻息肉中的作用
- 批准号:
8399713 - 财政年份:2011
- 资助金额:
$ 22.88万 - 项目类别:
Role for B-cell mediated olfactory loss in Chronic Sinusitis with Nasal Polyps
B 细胞介导的嗅觉丧失在慢性鼻窦炎伴鼻息肉中的作用
- 批准号:
8586309 - 财政年份:2011
- 资助金额:
$ 22.88万 - 项目类别:
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