Meharry RCMI Program in Women's Health Research

Meharry RCMI 妇女健康研究项目

• 批准号: 8491785
• 负责人: Anna CHERRIE Epps
• 金额: $ 188.06万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8491785
• 关键词: AIDS/HIV problem; African American; Applications Grants; Award; Behavioral Sciences; Bioinformatics; Caucasians; Caucasoid Race; Color; Core Facility; Development; Dimensions; Disease; Ehrlichiosis; Faculty; Female; Flow Cytometry; Fostering; Genes; Genetic Polymorphism; Genomics; Goals; HIV-1; Health Personnel; Health Status; Hispanics; Human; Human Resources; Immune; Incidence; Mental Health; Mentors; Mission; Peer Review; Physicians; Pilot Projects; Pregnancy; Premature Birth; Proteomics; Publications; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Resources; Scientist; Senior Scientist; Time; Tissues; Uterine Fibroids; Vitamin D Deficiency; Vitamin Deficiency; Woman; Women' s Health; biomedical scientist; diabetic gastroparesis; experience; health disparity; improved; medical schools; next generation; programs; success

The long range goal of this RCMI program renewal application is to expand and improve the capacity for women's health research, including HIV/AIDS at Meharry Medical College (MMC), placing particular emphasis on those diseases that disproportionately impact women of color. Numerous reports have documented differences in health status between Caucasian women and women of color, particularly African American (AA) and Hispanic Women. In the current application we seek to increase the capacity for women's health research at MMC by providing ongoing support for two recently hired RCMI investigators. Dr. P. Gangula will continue his studies on diabetic gastroparesis, which has a 4-times greater incidence in women, and Dr. N. Ismail will study immune regulation of human monocytic ehrlichiosis during pregnancy. We plan to recruit three mental health/behavioral science investigators to add this dimension of women's health research. In the pilot project core: Dr. X. Dong will study HIV-1 assembly, Dr. S. Halder will study Vitamin D deficiency and uterine fibroids in AA women and Dr. C. Thota will seek to correlate gene polymorphism and hypovitaminosis D in preterm birth. A strong team of senior scientists will facilitate a robust mentoring and faculty development experience for all RCMI Investigators. Two existing core facilities (Proteomic and Genomic & BL3/Flow Cytometry) will be merged /upgraded and a new core facility (Female Tissue Acquisition Core) will be developed. The RCMI program will be interfaced with other MMC research programs and the RTRN network to expand and enhance the resources and opportunities for investigators. The specific aims of the current application are to 1) exceed a 3 year average of 2 peer-reviewed publications/year/RCMI Investigator by the end of the award period; 2) to facilitate submission of investigator-initiated grant applications by all RCMI Investigators prior to their 3rd year of support; 3) to exceed 50% of RCMI investigators acquiring investigator-initiated support by the end of the award cycle; and 4) to have documented evidence that RCMI supported core facilities, bioinformatics support, as well as RTRN support were appropriately leveraged to achieve the above successes.

该RCMI计划续签应用的远距离目标是扩大和提高妇女健康研究的能力，包括Meharry医学院（MMC）的艾滋病毒/艾滋病，特别强调那些不成比例地影响有色女性的疾病。许多报告记录了高加索妇女与有色妇女，特别是非裔美国人（AA）和西班牙裔妇女之间健康状况的差异。在当前的应用中，我们试图通过为两名最近雇用的RCMI调查人员提供支持，以增加MMC的妇女健康研究能力。 P. gangula博士将继续他对糖尿病性胃轻瘫的研究，该研究的发生率更高4倍，N。Ismail博士将研究怀孕期间人类单核细胞性eHrllichiiceos的免疫调节。我们计划招募三名心理健康/行为科学研究者，以增加妇女健康研究的这一维度。在试点项目核心中：X. Dong博士将研究HIV-1组装，S。Halder博士将研究AA妇女中的维生素D缺乏症和子宫肌瘤，C。Thota博士将寻求将基因多态性和早产中的基因多态性和息肉症D。一个强大的高级科学家团队将为所有RCMI调查人员提供强大的指导和教师发展经验。将合并 /升级两个现有的核心设施（蛋白质组学和基因组和BL3 /流式细胞仪），并将开发一个新的核心设施（女性组织采集核心）。 RCMI计划将与其他MMC研究计划和RTRN网络联系起来，以扩展和增强研究人员的资源和机会。当前申请的具体目的是1）超过3年平均2个经过同行评审的出版物/年/RCMI调查员的平均值； 2）促进所有RCMI调查人员在支持第三年之前，所有RCMI调查人员提交了调查员发起的赠款申请； 3）超过RCMI调查人员的50％，这些调查人员在奖励周期结束时获得了研究人员的支持； 4）记录了RCMI支持的核心设施，生物信息学支持以及RTRN支持的证据，以实现上述成功。