Lifestyle Interventions in Overweight and Obese Pregnant Women

超重和肥胖孕妇的生活方式干预

基本信息

批准号：
8330446
负责人：
DYMPNA GALLAGHER
金额：
$ 14.01万
依托单位：
ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-30 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8330446
关键词：
Adipose tissue Adult Age Anthropometry Behavior Behavioral Biological Process Birth Blood Body Weight CCL2 gene Catchment Area Child Cost Analysis Counseling Data Dietary intake Dropout Enrollment Environment Fatty acid glycerol esters Funding Future Generations Glucose Guidelines High Density Lipoprotein Cholesterol Hospitals Infant Inflammatory Institute of Medicine (U.S.)Instruction Insulin Internet Intervention Intramuscular Knowledge Lead Leptin Life Lipids Magnetic Resonance Imaging Measurement Measures Metabolic Mothers Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Overweight Participant Physical activity Physicians Plasma Plasminogen Activator Inhibitor 1 Pregnancy Pregnant Women Prevalence Professional counselor Public Health Quality of life Questionnaires Randomized Controlled Trials Recommendation Risk Risk Factors Secondary to Socioeconomic Status Telephone Visceral Visit Weight Weight Gain Whole Body Plethysmography Woman adiponectin arm cohort cost effective group counseling improved in utero infant monitoring inflammatory marker lifestyle intervention low density lipoprotein triglyceride nutrition offspring pregnant prevent primary outcome reproductive subcutaneous treatment as usual

项目摘要

A randomized controlled trial is proposed to study the effect, in a cohort of racially and ethnically diverse group of ovenweight and obese pregnant women, of an Intensive Lifestyle Intervention (ILI) compared to Usual Care (UC) on gestational weight gain (GWG), infant fatness, and mothers' post-delivery weight retention. Women in the ILI arm will receive intensive counseling during pregnancy and group counseling after delivery regarding behavior, nutrition, and physical activity change. Visits to counselors will occur weekly and additional telephone and internet contacts will occur. The mothers' will be assessed at 14 and 36 weeks of pregnancy and at 12 weeks and 52 weeks post-delivery. The measurements will be anthropometry, whole body MRI, EchoMRI, and whole body plethysmography (BodPod). The infants' measurements will be anthropometry, whole body MRI, EchoMRI, and whole body plethysmography (PeaPod) for fatness 12 weeks and 52 weeks. Mothers and children will have cardio-metabolic risk factors measured in plasma. Data will be collected regarding mothers' dietary intake and physical activity (questionnaires and accelerometry) to assist in counseling. Other data to be collected include questionnaires on quality of life, socio-economic status. Careful record will be kept of expenses in providing the ILI, so that cost analysis of the intervention can be calculated. The study is powered on the primary outcome, fatness of the infants at birth. We require 180 participants to attain appropriate power. We will enroll 210 so as to allow for some dropouts along the way. Each mother will be followed during pregnancy and for a year post delivery. Each infant will be followed for a year after birth. We have the ability to continue to follow these participants if further funding is forthcoming, as they are all local to our hospital's catchment area and our own physicians. If aims are achieved, namely that both children and mothers profit from the intervention, there should be a paradigm shift in how oven/veight pregnant women are treated. At present, there is a dearth of behavioral advice and intervention relating to GWG and physical activity provided to these women. Positive results from our studv would provide evidence for ILI preventative intervention.

建议进行一项随机对照试验，以研究在一群不同种族和族裔中的效果与接受强化生活方式干预 (ILI) 的体重和肥胖孕妇相比常规护理 (UC) 对妊娠体重增加 (GWG)、婴儿肥胖和母亲产后体重的影响保留。 ILI 组的女性将在怀孕期间接受强化咨询和团体咨询产后有关行为、营养和身体活动的变化。将拜访辅导员每周都会进行额外的电话和互联网联系。母亲将在 14 岁和 36 岁接受评估怀孕周以及产后 12 周和 52 周。测量结果将是人体测量学、全身 MRI、EchoMRI 和全身体积描记法 (BodPod)。婴儿们的测量包括人体测量学、全身 MRI、EchoMRI 和全身体积描记法 (PeaPod) 适用于肥胖 12 周和 52 周。母亲和孩子都会有心脏代谢危险因素在血浆中测量。将收集有关母亲饮食摄入量和身体活动的数据（问卷和加速测量）以协助咨询。其他要收集的数据包括问卷调查生活质量、社会经济地位。将仔细记录提供 ILI 的费用，以便可以计算干预的成本分析。该研究的主要结果是肥胖出生时的婴儿。我们需要 180 名参与者才能获得适当的权力。我们将注册 210 名以便让对于一些一路上辍学的人。每位母亲在怀孕期间和产后一年都会受到跟踪送货。每个婴儿出生后将被跟踪一年。我们有能力继续关注这些参与者是否可以获得进一步的资金，因为他们都来自我们医院的服务区域和我们的本地自己的医生。如果目标实现，即儿童和母亲都从干预中受益，对待烤箱/veight孕妇的方式应该发生范式转变。目前，有一个缺乏向这些妇女提供的与 GWG 和身体活动相关的行为建议和干预措施。我们研究的积极结果将为流感样疾病预防干预提供证据。