Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women

乳腺癌的差异：西班牙裔和 NHW 女性的发展和生存

基本信息

批准号：
8540349
负责人：
Martha L SLATTERY
金额：
$ 55.99万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-25 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8540349
关键词：
AKT1 gene Admixture Affect Age American Indians Androgens Apoptosis Applications Grants Area Arizona Aspirin Behavioral Biological Body Weight Changes Body mass index Breast Breast Cancer Genetics Breast Cancer Risk Factor California Cancer Etiology Candidate Disease Gene Case-Control Studies Centers for Disease Control and Prevention (U.S.)Characteristics Cities Colorado Complex DNA Data Development Diagnosis Diet Disease ESR1 gene ESR2 gene Epidemiology Estrogen Receptor Status Estrogen receptor negative Estrogens Ethnic Origin Etiology European Evaluation FRAP1 gene Gene Frequency Genes Genetic Genetic Polymorphism Genetic Transcription Genetic Variation Genotype Goals Growth Factor Haplotypes Hispanics Hormonal Hormone replacement therapy Hormones I-kappa B Proteins IGF1 gene IGFBP3 gene IL4 gene IL6 gene IL8 gene IRS1 gene Ibuprofen Incidence Inflammation Insulin Interleukin-1 Interleukin-10 Interview Life Life Style Menopausal Status Mexico Modeling Monitor NF-kappa B Native Americans Native-Born New Mexico Non-Steroidal Anti-Inflammatory Agents Not Hispanic or Latino Obesity Oranges PTEN gene Pathway interactions Patient Self-Report Pharmaceutical Preparations Pharmacotherapy Physical activity Population Population Study Principal Investigator Proteins Proto-Oncogene Proteins c-akt Race Regulation Relative Risks Reproductive History Research Resources Risk Risk Factors Role SHBG gene STAT1 gene STAT6 gene STK11 gene San Francisco Signal Pathway Signal Transduction Signaling Pathway Gene Somatotropin Southwestern United States Stage at Diagnosis TNF gene TSC1 gene Testing Time United States Utah Vascular Endothelial Growth Factors Woman Work breast cancer diagnosis cancer risk cell growth cost cytokine energy balance epidemiologic data genetic variant health disparity human FRAP1 protein insulin-related factor interest lifestyle factors malignant breast neoplasm mortality neoplasm registry population based programs ribosomal protein S6 kinase, 70kD, polypeptide 2 social tumor tumor registry

项目摘要

The incidence rates of breast cancer vary more than two-fold between Hispanic and non-Hispanic white (NHW) women; Hispanic women have worse survival after diagnosis than NHW women. We propose to evaluate these health disparities in breast cancer development and surival along the continuation of American Indian to NHW women utilizing existing resources from the 4 Corner's States, California, and Mexico City. Existing resources utilized will be behorial and social lifestyle exposure data along with DNA obtained at the time of interview. Survival data has been ongoing and will continue to be monitored via local SEER and CDC tumor registries. Genetic and lifestyle data are available from approximately 8039 Hispanic and NHW cases of breast cancer and population-based controls. By pooling resources from three studies, we will efficiently examine a biological pathway that we believe is important to breast cancer development and survival and that influences differences in breast cancer rates among Hispanic and NHW women. Evaluation of genetic factors will focus on a pathway that appears to work in conjunction with insulin-, estrogen-, and inflammation-related pathways and represents a point of convergence. This pathway, which we call the Convergence of Hormones, Inflammation, and Energy Functioning (CHIEF) Signaling Pathway has not been studied comprehensively in either Hispanic or non-Hispanic white women and will include enes to be studied include SOC1, SOC2, AKT, FRAP1(alias mTOR), P13K, STK11, AMP, PTEN, VEGF, & S6K1,S6K2, CRP, NFKB, IKB, IL10, IL8, IL6, TNFalpha using an Illumina platform. Breast cancer associations will be tested between genetic polymorphisms and haplotypes of these genes in Hispanic and NHW women and by proportion of American Indian ancestry. Interaction of signaling pathway genes with each other and with NSAIDs, aspirin, BMI, estrogen, and physical activity will be examined. These genetic factors will be evaluated with survival to determine their contribution to survival differences observed for Hispanic and NHW women.

乳腺癌的发病率在西班牙裔和非西班牙裔白人（NHW）妇女；诊断后的西班牙裔妇女的生存率较差比NHW妇女。我们建议评估乳腺癌中的这些健康差异沿着美洲印第安人对NHW妇女的延续的发展和勘测利用来自四角州，加利福尼亚和墨西哥城的现有资源。现有的资源将是演讲和社会生活方式曝光数据以及 DNA在面试时获得。生存数据一直在进行，将继续通过局部先知和CDC肿瘤登记处进行监测。遗传和生活方式数据是可从大约8039个西班牙裔和NHW乳腺癌病例以及基于人群的控件。通过从三项研究中汇总资源，我们将有效检查我们认为对乳腺癌发育很重要的生物学途径和生存以及影响西班牙裔乳腺癌率的差异和 NHW妇女。评估遗传因素将集中于似乎有效的途径与胰岛素，雌激素和炎症相关途径以及代表收敛点。这条途径，我们称之为激素，炎症和能量功能（主要）信号通路具有在西班牙裔或非西班牙裔白人妇女中尚未全面研究将包括要研究的ENE，包括SOC1，SOC2，AKT，FRAP1（别名MTOR），P13K， STK11，AMP，PTEN，VEGF和S6K1，S6K2，CRP，NFKB，IKB，IL10，IL8，IL8，IL6，TNFALPHA 使用Illumina平台。乳腺癌关联将在遗传之间进行测试这些基因在西班牙裔和NHW妇女中的多态性和单倍型以及美洲印第安血统的比例。信号通路基因与彼此以及NSAID，阿司匹林，BMI，雌激素和体育活动将是检查。这些遗传因素将以生存评估，以确定其对西班牙裔和NHW妇女观察到的生存差异的贡献。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Associations between ALDH1A1 polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white women diagnosed with breast cancer: the Breast Cancer Health Disparities Study.

诊断患有乳腺癌的西班牙裔和非西班牙裔白人女性中 ALDH1A1 多态性、饮酒量和死亡率之间的关联：乳腺癌健康差异研究。

DOI：
10.1007/s10549-017-4600-2
发表时间：
2018
期刊：
Breast cancer research and treatment
影响因子：
3.8
作者：
Xia,Zhiyu;Baumgartner,KathyB;Baumgartner,RichardN;Boone,StephanieD;Hines,LisaM;John,EstherM;Wolff,Roger;Slattery,MarthaL;Connor,AvonneE
通讯作者：
Connor,AvonneE