Assisted Reproductive Technology & Risk of Childhood Cancer

辅助生殖技术

• 批准号: 8446149
• 负责人: BARBARA Joan LUKE
• 金额: $ 56.92万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2016-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8446149
• 关键词: Affect; Angelman Syndrome; Assisted Reproductive Technology; Beckwith-Wiedemann Syndrome; Birth; California; Case Series; Certification; Child; Clinic; Conceptions; Congenital Abnormality; Data; Databases; Disease; Disease Outcome; Embryonal Cancers; Fertility; General Population; Germ Cells; Germ-Line Mutation; Hepatoblastoma; Illinois; Incidence; Infant; Infertility; Insurance Coverage; Link; Low Birth Weight Infant; Malignant Childhood Neoplasm; Malignant Neoplasms; Massachusetts; Maternal Age; Medical; New Jersey; New York; New York City; Outcome; Perinatal; Population; Pregnancy; Prevalence; Procedures; Reporting; Resources; Risk; Sample Size; Services; Societies; Time; United States; assisted reproduction; cancer risk; cancer type; case control; child bearing; cohort; disorder risk; early childhood; high risk; imprint; in utero; neoplasm registry; premature; prenatal; programs; success

DESCRIPTION (provided by applicant): Use of assisted reproductive technology (ART) has risen steadily in the United States during the past two decades due to several reasons, including childbearing at older maternal ages and increasing insurance coverage. Studies have reported significantly higher risks of adverse perinatal outcomes in assisted- versus spontaneous-conception pregnancies, including an excess of prematurity, low birthweight, and birth defects. ART and/or infertility may influence the incidence of other conditions with prenatal origins, such as childhood cancer. In addition, the prevalence of imprinting disorders such as Beckwith-Wiedemann and Angelman syndromes is elevated among children conceived by ART; some of these disorders, in turn, drastically raise the risk of several embryonal cancers that occur in early childhood. Several cohort, case-control, and case- series studies of assisted reproduction and childhood cancer have reported null results, although all were limited by small sample size and could not differentiate specific cancer types. One study that focused specifically on hepatoblastoma found that use of infertility treatment or assisted reproduction was associated with a nine-fold increased risk of disease. Using the resources of the Society for Assisted Reproductive Technology (SART) and the birth and cancer registries in 20 States and New York City, we propose to conduct the largest study to date of ART and childhood cancer risk. SART maintains an ongoing national database of programs that provide ART services in the United States as mandated by the federal Fertility Success Rate and Certification Act of 1992 [PL 102-493]. As of 2006, the latest year of data available, this included comprehensive data (including identifiers sufficient for linkage) on 138,198 ART cycles from 483 clinics resulting in 41,343 pregnancies and 54,656 infants for a single year. We propose to link the data from the SART database from 2004-2013 to the birth and cancer registries of 20 states and New York City, including the five states with the highest numbers of ART births (California, New York, Illinois, New Jersey, and Massachusetts), to create a cohort of approximately 30 million children, including over 467,000 conceived by ART to evaluate the association between assisted reproduction and the risk for childhood cancer. The specific aim of this study is to compare the incidence of childhood cancer in children with assisted conception to that in the general population.

描述（由申请人提供）：由于几个原因，在过去的二十年中，使用辅助生殖技术（ART）在美国稳步上升，包括年龄较大的母亲时代的生育和增加的保险范围。研究报告说，辅助和自发概念怀孕的不良围产期结局的风险明显更高，包括早产，低出生体重和出生缺陷。艺术和/或不育可能会影响产前起源（例如儿童癌）的其他疾病的发生率。此外，在艺术所构想的儿童中，贝克维斯·威德曼和安吉尔曼综合症等烙印疾病的普遍性被提升。反过来，其中一些疾病大大提高了幼儿时代发生的几种胚胎癌的风险。几个队列，病例对照和辅助生殖和儿童癌症的病例系列研究报告了无效的结果，尽管所有这些结果都受样本量较小的限制，并且无法区分特定的癌症类型。一项专门针对肝母细胞瘤的研究发现，使用不孕治疗或辅助繁殖与疾病风险增加了9倍。利用辅助生殖技术协会（SART）的资源以及20个州和纽约市的出生和癌症注册机构，我们建议对艺术和儿童癌症风险进行最大的研究。 SART维护了一个正在进行的国家数据库，该数据库根据1992年《联邦生育成功率和认证法》的规定，在美国提供艺术服务[PL 102-493]。截至2006年，最新的数据可用，其中包括483个诊所的138,198次艺术周期的综合数据（包括足以连接的标识符），一年中有41,343例怀孕和54,656名婴儿。我们建议将SART数据库的数据与20个州和纽约市的出生和癌症登记处联系起来，其中包括五个具有艺术生物数量最多的州（加利福尼亚，纽约，伊利诺伊州，新泽西州，新泽西州和马萨诸塞州），以使467,000个疗法的陪伴和诸如癌症之间的大约3000万儿童的群体和对癌症的群体进行了评估。这项研究的具体目的是将具有辅助概念的儿童儿童癌的发病率与普通人群的发生率进行比较。