Interaction of HSV-2 in Veterans with Chronic Hepatitis C Co-Infection

退伍军人中 HSV-2 与慢性丙型肝炎合并感染的相互作用

• 批准号: 8453247
• 负责人: Mary Jane Burton
• 金额: --
• 依托单位: G V SONNY MONTGOMERY VA MEDCIAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8453247
• 关键词: Advanced Development; Biological Assay; Caring; Chronic Disease; Chronic Hepatitis C; Controlled Clinical Trials; Cypress; Data; Development; Diagnosis; Diagnostic; Double-Blind Method; Future; Genotype; Goals; HIV; HIV Infections; Hepatitis B; Hepatitis B Virus; Hepatitis C; Hepatitis C Therapy; Hepatitis C virus; Herpes Simplex Infections; Herpesvirus 1; Human Herpesvirus 2; Immunoglobulin G; Individual; Infection; Laboratories; Lead; Liver Fibrosis; Liver diseases; Medical; Methods; Modeling; Morbidity - disease rate; Natural History; Oral; Outcome; Patients; Performance; Persons; Pharmaceutical Preparations; Pilot Projects; Placebo Control; Play; Population; Predictive Value; Provider; Randomized; Randomized Controlled Trials; Research; Role; Schistosoma; Serum; Signal Transduction; Simplexvirus; Technology; Testing; Therapeutic; United States; Veterans; Viral; Viral Load result; Virus Replication; Work; design; improved; mortality; novel strategies; prevent; response; screening; valacyclovir

DESCRIPTION (provided by applicant): Chronic hepatitis C is a leading cause of morbidity and mortality in veterans. Current treatment options have only limited efficacy in veterans and are poorly tolerated. Herpes simplex type 2 virus co-infection commonly occurs in veterans with hepatitis C but is poorly studied. In patients with HIV, treatment of herpes simplex type 2 with well-tolerated oral drugs improves outcomes. We propose to study similar interactions of herpes simplex type 2 in hepatitis C. We also will begin preliminary studies to examine potential interactions of HSV-1 infection in HCV. Because of the varying performance of screening assays for HSV-2, our first aim is to validate a two-step approach for confirming herpes simplex type 2 infection in veterans with HCV. This will allow us to identify accurately persons with HSV-2/HCV infection AND study the effects of HSV-2 on HCV. In aim 2, we will perform a randomized, double-blind, placebo-controlled clinical trial evaluating the effect of HSV-2 suppression on HCV viral load in patients with genotype 1 hepatitis C virus and herpes simplex type-2 co-infection. In aim 3, we will examine the effects of HSV-1 suppression on serum hepatitis C viral load in herpes simplex type-1/hepatitis C virus co-infected veterans without evidence of herpes simplex type 2 infection. The VA is the largest single provider of care for persons with hepatitis C in the United States, but the majority of hepatitis C infected veterans are unable to receive or benefit from currently available therapies. This proposal examines a novel approach to delaying hepatitis C progression by suppressing herpes simplex viruses. Evaluating this approach could lead to improved, well-tolerated therapies for HCV in difficult-to-treat populations.

描述（由申请人提供）： 慢性丙型肝炎是退伍军人发病率和死亡率的主要原因。当前的治疗方案仅在退伍军人中的疗效有限，并且容忍度不佳。单纯疱疹2型病毒共感染通常发生在患有乙型肝炎的退伍军人中，但对研究很少。在艾滋病毒患者中，用耐受耐受性的口服药物治疗单纯疱疹2型疱疹可改善预后。我们建议研究丙型肝炎中单纯疱疹2型的类似相互作用。我们还将开始初步研究，以检查HSV-1感染在HCV中的潜在相互作用。 由于HSV-2的筛选测定的性能各不相同，我们的第一个目的是验证一种两步方法，以确认HCV退伍军人中的单纯疱疹2型感染。这将使我们能够准确地识别患有HSV-2/HCV感染的人，并研究HSV-2对HCV的影响。在AIM 2中，我们将进行一项随机，双盲，安慰剂对照的临床试验，评估HSV-2抑制对HCV病毒载量的影响1乙肝病毒C病毒和疱疹Simples-2型共感染。在AIM 3中，我们将检查HSV-1抑制对血清丙型肝炎病毒载荷的影响，而单纯1/丙型肝炎病毒共同感染的退伍军人，而没有疱疹单纯疱疹2型感染。 VA是美国患有丙型肝炎患者的最大的单一护理提供者，但是大多数丙型肝炎感染的退伍军人无法从目前可用的疗法中获得或受益。该提案研究了一种通过抑制单纯疱疹病毒来延迟丙型肝炎进展的新方法。评估这种方法可能会导致难以治疗种群中HCV的改善，耐受性良好的疗法。