The Cognitive and Neural Basis of Apathy in Frontotemporal Degeneration

额颞叶退化中冷漠的认知和神经基础

基本信息

批准号：
8370048
负责人：
Lauren M Massimo
金额：
$ 4.22万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-01-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8370048
关键词：
Advanced Practice Nurse Anatomy Anterior Area Behavior Behavioral Behavioral Symptoms Belief Biological Brain Brain imaging Caregiver Burden Caregivers Cessation of life Cognitive Corpus striatum structure Data Databases Disease Emotions Family Caregiver Family Nursing Fellowship Frontotemporal Dementia Functional disorder Geriatric Nursing Goals Health Professional Human Impairment Individual National Research Service Award Interruption Intervention Knowledge Laboratory Study Lead Literature Magnetic Resonance Imaging Medial Modeling Morbidity - disease rate Motivation National Institute of Nursing Research National Research Service Awards Neurobiology Neurodegenerative Disorders Neurological Nursing Neurologist Neurosciences Nurses Nursing Research Outcome Pain Patients Philadelphia Physiological Prefrontal Cortex Process Quality of life Reaction Time Reporting Research Research Personnel Research Priority Research Proposals Research Training Rewards Risk Scientist Social Behavior Staging Strategic Planning Symptoms Syndrome System Task Performances Temporal Lobe Testing Training Variant Work base cingulate cortex computerized diagnostic accuracy effective intervention effective therapy experience frontal lobe illness length improved innovation insight mortality neurobehavioral neuroimaging neuron loss neuropsychiatry neuropsychological novel pre-doctoral relating to nervous system response skills social neuroscience tool

项目摘要

The purpose of this individual National Research Service Award (NRSA) is to provide research training for a neuroscience nurse to become an independent investigator focusing on the biological mechanisms that contribute to neurobehavioral changes such as apathy in patients with neurodegenerative disease (ND). In addition to scholarly coursework and the acquisition of research skills, I propose to focus this NRSA on impairments of goal-directed behavior that are very common but understudied in ND. The syndrome of apathy, defined as a reduction in self-generated or voluntary behavior,1 has profound consequences for morbidity and mortality in the patient and for family caregiver burden. Apathy is one of the primary neuropsychiatric syndromes associated with the disruption of the frontal-striatal system, but the behavioral and biological mechanisms underlying apathy are not well understood. Apathy is especially prevalent in behavioral variant Frontotemporal Degeneration (bvFTD), where it is reported in up to 90.5% of mild stage patients.2 I hypothesize three subtypes of apathy that compromise distinct components of goal-directed behavior, and that each of these subtypes of apathy are associated with a specific neuroanatomic substrate. I will investigate these empirically using a novel computerized reaction time test and neuroimaging. I have had more than 5 years experience as an Advanced Practice Nurse and Research Nurse Coordinator in a nationally ranked laboratory that studies the neural basis for behavior in ND and have direct access to a large database of neuropsychological and neuroimaging data. My research training will be guided by two internationally known scientists, Dr. Lois Evans, a well-known gerontological nurse expert and leader, and Dr. Murray Grossman, a highly acclaimed cognitive neurologist and experienced scientist. The long-term impact of this research training will be profound for patients with ND, their caregivers, and families. Current treatment of apathy has been hindered because of our poor understanding of the mechanisms underlying this condition. The precise characterization of apathy will allow us to implement the most appropriate therapy for a patient. Consistent with the National Institute of Nursing Research (NINR) priorities, this work will lead to a better understanding of why these behaviors occur and with this knowledge, tailored interventions can be implemented by professional and lay caregivers.

该个别国家研究服务奖（NRSA）的目的是为神经科学护士提供研究培训，成为一名独立研究者，专注于神经性疾病患者（ND）患者的神经行为变化（例如冷漠）的生物学机制。除了学术课程和获得研究技能的获得外，我还建议将这种NRSA集中在目标指导行为的损害上，这些行为非常普遍，但在ND中被研究了。冷漠综合征被定义为减少自我生成或自愿行为的综合征，对患者和家庭护理人员负担的发病率和死亡率产生了深远的影响。冷漠是与额叶系统中断相关的主要神经精神综合症之一，但是对冷漠的行为和生物学机制却尚不清楚。 Apathy is especially prevalent in behavioral variant Frontotemporal Degeneration (bvFTD), where it is reported in up to 90.5% of mild stage patients.2 I hypothesize three subtypes of apathy that compromise distinct components of goal-directed behavior, and that each of these subtypes of apathy are associated with a specific neuroanatomic substrate.我将使用新型的计算机反应时间测试和神经影像学经验研究这些。我在一个全国排名的实验室中担任高级实践护士和研究护士协调员的经验超过5年，该实验室研究了ND行为的神经基础，并可以直接访问大型神经心理学和神经影像学数据的数据库。我的研究培训将由两位国际知名的科学家，著名的老年医学护士专家和领导者路易斯·埃文斯（Lois Evans）以及备受赞誉的认知神经科医生兼经验丰富的科学家Murray Grossman博士来指导。这项研究培训的长期影响将对ND，护理人员和家庭的患者产生深远的影响。由于我们对这种情况下的机制的理解不足，因此目前对冷漠的治疗受到了阻碍。冷漠的精确表征将使我们能够为患者实施最合适的疗法。与国家护理研究所（NINR）的优先事项一致，这项工作将更好地理解这些行为的发生，并且随着这些知识，专业和外行护理人员可以实施量身定制的干预措施。