Behavioral and Neurochemical Effects of Therapeutic d-Amphetamine

治疗性 d-安非他明的行为和神经化学作用

• 批准号: 8427910
• 负责人: Jonathan Michael Slezak
• 金额: $ 2.63万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2013-08-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8427910
• 关键词: Acute; Adderall; Address; Adolescence; Adult; Affect; Amphetamines; Attention; Attention deficit hyperactivity disorder; Behavioral; Behavioral Model; Brain; Child; Childhood; Chronic; Clinical; Clinical Treatment; Data; Dextroamphetamine; Disease; Disease model; Dose; Exposure to; Goals; Human; Inbred SHR Rats; Lead; Long-Term Effects; Methylphenidate; Modeling; National Institute of Mental Health; Nicotine; Oral; Oral Administration; Outcome; Papio; Patients; Pharmaceutical Preparations; Plasma; Primates; Reaction Time; Regimen; Research; Rodent; Rodent Model; Saimiri; Testing; Therapeutic; Therapeutic Effect; Time; Toxic effect; abstracting; combat; dopamine system; dopaminergic neuron; improved; neurochemistry; neuropsychiatry; neurotoxic; neurotoxicity; nonhuman primate; psychostimulant; response

Modified Project Summary/Abstract Section Attention deficit/hyperactivity disorder (ADHD) is a prevalent neuropsychiatric illness affecting 5 to 9% of children and 1 to 5% of adults. Oral administration of psychostimulant medication such as amphetamine (e.g., Adderall) is a first-line treatment to combat ADHD-associated deficits. A priority at the National Institute of Mental Health is to examine and improve upon existing therapeutic strategies for illnesses such as ADHD. Although short-term therapeutic effects of amphetamine have been established, less is known concerning the long-term effects of chronic administration. Assessment of repeated therapeutic amphetamine use has become especially critical because childhood ADHD is now known to often persist into adolescence and adulthood, increasing the potential for protracted amphetamine use. The overall goal of the current project is to assess behavioral and neurochemical effects of oral therapeutic doses of chronic d-amphetamine. An accepted behavioral model for testing agents that are effective in treating ADHD (a serial reaction-time task) will be used to determine a therapeutic dose of oral d-amphetamine. Once therapeutic doses are determined, they will be administered under a chronic regimen to assess long-term behavioral and neurochemical effects. Findings from the current studies will provide important new data on chronic therapeutic amphetamine treatment.

修改的项目摘要/摘要部分 注意缺陷/多动症（ADHD）是一种普遍的神经精神疾病，影响5至9％的儿童和1-5％的成年人。 口服精神刺激药物（例如苯丙胺（例如Adderall））是对抗ADHD相关缺陷的一线治疗方法。 美国国家心理健康研究所的优先事项是检查和改进有关多动症等疾病的现有治疗策略。 尽管已经建立了苯丙胺的短期治疗作用，但关于慢性给药的长期影响的知之甚少。 对重复治疗的苯丙胺使用的评估变得尤为重要，因为现在众所周知，儿童多动症通常会持续到青春期和成年期，从而增加了持久使用苯丙胺的潜力。 当前项目的总体目标是评估慢性D-苯丙胺口服治疗剂量的行为和神经化学作用。 用于有效治疗ADHD的测试剂的公认行为模型（串行反应时间任务）将用于确定口服D-苯丙胺的治疗剂量。 一旦确定治疗剂量，将在慢性方案下进行给药，以评估长期行为和神经化学作用。 当前研究的发现将提供有关慢性治疗性苯丙胺治疗的重要新数据。