Meningioma: Risk Factors and Quality of Life

脑膜瘤：危险因素和生活质量

• 批准号: 7926014
• 负责人: Joellen M. SCHILDKRAUT
• 金额: $ 13.29万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7926014
• 关键词: Accounting; Address; Age; Age-Years; Amendment; Androgen Receptor; Androgens; Area; Attention; Benign; Blood; Brain Neoplasms; Case-Control Studies; Categories; Cellular Phone; Cephalic; Clinical; Connecticut; County; Craniocerebral Trauma; DNA; DNA Repair; Data; Data Collection; Development; Diagnosis; Digit structure; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Estrogens; Ethnic Origin; Etiology; Exposure to; Family history of; Female; Genetic; Genetic Polymorphism; Geographic Locations; Geography; Histologic; Hormonal; Hormone Receptor; Hormone replacement therapy; Hormones; Housing; Individual; Intracranial Meningiomas; Intracranial Neoplasms; Ionizing radiation; Ki-67 Antigen; Lesion; Male Pattern Baldness; Malignant Neoplasms; Massachusetts; Methods; Neoplasms; Neurologic; North Carolina; Oral Contraceptives; Outcome; Pathologic; Patients; Prevalence; Process; Progesterone; Quality of life; Questionnaires; Radiation; Recording of previous events; Reporting; Risk; Risk Factors; San Francisco; Site; Specimen; Statutes and Laws; Study Subject; Targeted Research; Telephone; Testing; Texas; Time; Tumor Tissue; United States; Woman; benign brain tumor cancer registries; cdc Genes; genetic risk factor; male; men; meningioma; neoplastic cell; population based; receptor; reproductive; sex; tumor

DESCRIPTION (provided by applicant): No large-scale study within the United States has examined any aspect of the epidemiology of intracranial meningiomas, a lesion which accounts for up to 25% of all primary intracranial neoplasms. We propose to conduct a population-based case/control study of meningioma within the states of Connecticut, Massachusetts, North Carolina, and Texas as well as the San Francisco Bay area under the mechanism of an integrated R01 (Note that identical applications are submitted for all five sites). Cases will be selected using rapid case ascertainment and will include all male; and female individuals diagnosed with a histologically confirmed intra-cranial meningioma between the ages of 20 and 79 years from 7/1/2006 through 6/30/2010 in the above listed regions. Control subjects will be identified via random-digit dial methods and matched to the cases by sex, ethnicity, geographic location, and five-year age category. Study subjects will be administered a telephone questionnaire to collect information on the two primary categories of risk, exposure to ionizing radiation and hormones as well as additional risk factors such as family history of meningioma and other tumors, cell-phone utilization, and head trauma as well as questions on outcome and quality of life. Parraffin-embedded tumor tissue blocks will be obtained for case subjects to allow for 1) a uniform histological review, and 2) immunohistochemical testing for estrogen, progesterone, androgen and MIB-1 receptors. Blood or buccal specimens will be collected from all study subjects for testing of DNA polymorphisms in DNA repair and cell cycle genes. This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma.

描述（由申请人提供）：美国境内尚无大规模研究对颅内脑膜瘤流行病学的任何方面进行过检查，颅内脑膜瘤占所有原发性颅内肿瘤的 25%。我们建议在康涅狄格州、马萨诸塞州、北卡罗来纳州和德克萨斯州以及旧金山湾区在综合 R01 机制下进行一项基于人群的脑膜瘤病例/对照研究（请注意，为以下项目提交了相同的申请）所有五个站点）。将通过快速病例确定来选择病例，并且将包括所有男性； 2006年7月1日至2010年6月30日期间在上述地区被诊断患有经组织学证实的颅内脑膜瘤、年龄在20岁至79岁之间的女性个体。对照受试者将通过随机数字拨号方法进行识别，并按性别、种族、地理位置和五年年龄类别与病例进行匹配。研究对象将接受电话调查问卷，以收集有关两个主要风险类别的信息：电离辐射和激素暴露以及其他风险因素，例如脑膜瘤和其他肿瘤的家族史、手机使用情况和头部外伤。以及有关结果和生活质量的问题。将为病例对象获取石蜡包埋的肿瘤组织块，以便进行 1) 统一的组织学检查，以及 2) 对雌激素、孕激素、雄激素和 MIB-1 受体进行免疫组织化学检测。将从所有研究对象采集血液或口腔样本，用于检测 DNA 修复和细胞周期基因的 DNA 多态性。这项研究代表了首次集中精力检查脑膜瘤的环境和遗传风险因素。