Corneoscleral Biomechanics and Intraocular Pressure

角巩膜生物力学和眼压

• 批准号: 8527785
• 负责人: JUN LIU
• 金额: $ 33.46万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8527785
• 关键词: Affect; Age; Aging; Aging-Related Process; Anisotropy; Aqueous Humor; Biomechanics; Blindness; Blood; Canis familiaris; Characteristics; Clinical; Clinical Management; Communities; Cornea; Development; Eye; Future; Glaucoma; Goals; Human; Individual; Investigation; Knowledge; Lead; Liquid substance; Measurable; Measurement; Measures; Monitor; Outcome; Physiologic Intraocular Pressure; Physiological; Play; Predisposition; Property; Relaxation; Research; Risk; Risk Factors; Role; Simulate; Speed; Stimulus; Stress; Structure; Techniques; Testing; Time; Tissues; Ultrasonics; Ultrasonography; Variant; age related; experience; improved; in vivo; indexing; novel; optic nerve disorder; tool; treatment strategy

DESCRIPTION (provided by applicant): Corneoscleral biomechanical properties may influence the characteristics of short-term IOP elevations, and thus play an important role in an individual's susceptibility to glaucoma. Our hypotheses are: (a) eyes with certain corneoscleral biomechanical properties (i.e., low stiffness) are more capable of damping IOP (i.e., smaller, slower, and/or shorter elevations), and (b) these corneoscleral biomechanical properties are affected by aging processes resulting in reduced capability to dampen IOP. The specific aims are: Aim 1: To test the prediction that corneoscleral biomechanical properties affect short-term, dynamic IOP variations. We will examine in enucleated canine globes the influence of the natural variance or experimentally altered corneoscleral properties on the parameters of IOP elevations. Aim 2: To test the prediction that age-associated differences in corneoscleral biomechanical properties are correlated with the eye's ability to dampen IOP. We will examine whether there are age-related differences in physiologic, short- term IOP dynamics in human eyes. We will then investigate whether the age-associated differences in IOP parameters can be explained by the age-associated differences in the corneoscleral biomechanical properties. A novel ultrasonic technique will be used to non-invasively measure corneal properties in the human eye, establishing feasibility for future in vivo assessment and monitoring of corneoscleral properties. Significance: The proposed studies will detail the influences of the biomechanical characteristics of the corneoscleral shell on short-term IOP elevations, which will lead to the discovery of new measurable and modifiable glaucoma susceptibility factors that will improve clinical management of glaucoma.

描述（由申请人提供）：角巩膜生物力学特性可能影响短期眼压升高的特征，因此在个体对青光眼的易感性中发挥重要作用。我们的假设是：(a) 具有某些角巩膜生物力学特性（即低硬度）的眼睛更有能力抑制 IOP（即较小、较慢和/或较短的高度），以及 (b) 这些角巩膜生物力学特性受到老化过程导致抑制眼压的能力下降。具体目标是： 目标 1：测试角巩膜生物力学特性影响短期动态 IOP 变化的预测。我们将在去核犬眼球中检查自然方差或实验改变的角巩膜特性对眼压升高参数的影响。目标 2：检验预测，即与年龄相关的角巩膜生物力学特性差异与眼睛抑制 IOP 的能力相关。我们将检查人眼的生理、短期眼压动态是否存在与年龄相关的差异。然后，我们将研究与年龄相关的眼压参数差异是否可以通过与年龄相关的角巩膜生物力学特性差异来解释。一种新颖的超声波技术将用于非侵入性地测量人眼的角膜特性，为未来体内评估和监测角巩膜特性奠定了可行性。 意义：拟议的研究将详细说明角巩膜壳的生物力学特征对短期眼压升高的影响，这将导致发现新的可测量和可改变的青光眼易感因素，从而改善青光眼的临床治疗。