Phase Contrast OCT for Non-Invasive Imaging of Retinovascular Disease

用于视网膜血管疾病非侵入性成像的相差 OCT

• 批准号: 8523954
• 负责人: SCOTT E FRASER
• 金额: $ 40.41万
• 依托单位: VISDEX CORPORATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8523954
• 关键词: Age; Algorithms; American; Angiography; Blindness; Blood Circulation; Blood Vessels; Blood capillaries; Caring; Choroidal Neovascularization; Classification; Clinical; Communities; Computer software; Consult; Data; Data Analyses; Detection; Development; Diabetic Retinopathy; Diagnosis; Diagnostic; Diagnostic tests; Disease; Dyes; Early Diagnosis; Evaluation; Eye; Financial compensation; Fluorescein Angiography; Fundus photography; Goals; Gold; Image; Image Analysis; Imagery; Imaging Device; Imaging technology; Informatics; Lead; Legal patent; Macular degeneration; Methods; Microaneurysm; Motion; Mydriasis; Ophthalmologist; Optical Coherence Tomography; Optics; Optometrist; Outcome; Patients; Performance; Phase; Process; Provider; Pupil; Reading; Research; Research Infrastructure; Resolution; Retinal; Retinal Neovascularization; Secondary to; Solutions; Specialist; Speed; System; Techniques; Technology; Time; Vascular Diseases; Visual; Work; capillary; commercial application; cost; design; head-to-head comparison; high risk; imaging modality; improved; instrument; intravenous injection; neovascularization; public health relevance; screening; software development; tool; visual feedback

DESCRIPTION (provided by applicant): Since its introduction in the 1960's, fluorescein angiography (FA) has been the gold standard for retinal vascular diagnosis. However, FA is costly, invasive, and time-consuming, which limits its usefulness as a screening tool. As a potential non-invasive alternative to FA for diagnosing retinovascular disease, we have developed an imaging method called phase contrast optical coherence tomography (PC-OCT). Our technology uses specialized software analysis of data acquired from clinically available optical coherence tomography imaging systems to provide an additional functionality of three-dimensional angiography. The majority of eye care in the US is currently performed by optometrists, and in many underserved communities, they are the sole providers. Unfortunately, most optometrists cannot perform FA due to its requirement for intravenous injection. Therefore, retinal vascular diagnostics are limited to clinical exam and fundus photography. Patients receiving optometric care would benefit from a non-invasive alternative to FA for improved screening of retinovascular diseases, especially in these underserved communities. PC-OCT has the potential to provide a low-cost and convenient vascular screening method, which could result in timely referrals to retinal specialists, as well as improved visual outcomes. To advance PC-OCT as a retinovascular imaging tool, we have the following goals: (1) develop PC-OCT software into a faster automated platform for application to commercial spectral domain (SD-OCT) systems; (2) optimize optical scanner performance for imaging both dilated and non-dilated pupils; and (3) demonstrate the feasibility of PC-OCT as a wide-field screening diagnostic for diabetic retinopathy. The visualization capabilities of PC-OCT imaging will be compared directly against fundus photography, the current diagnostic standard for eye care professionals. Successful completion of Phase II will result in an automated software package capable of producing PC-OCT microvascular images from the raw data of a commercial SD-OCT system, allowing for convenient vascular imaging accessible to all eye care practitioners. This could lead to better-quality detection capabilities for retinovascular disease and potentially improved visual outcomes.

描述（由申请人提供）：自1960年代引入以来，荧光素血管造影（FA）一直是视网膜血管诊断的金标准。但是，FA是昂贵，侵入性和耗时的，这限制了其作为筛查工具的用处。作为用于诊断视网膜疾病的FA的潜在无创替代方法，我们开发了一种称为相比造影剂光学相干断层扫描（PC-OCT）的成像方法。我们的技术使用专门的软件分析，对从临床可用的光学相干断层扫描成像系统中获取的数据进行了数据，以提供三维血管造影的额外功能。目前，美国大部分的眼保健是由验光师进行的，在许多服务不足的社区中，它们是唯一的提供者。不幸的是，大多数验光师由于对静脉注射的要求而无法执行FA。因此，视网膜血管诊断仅限于临床检查和眼底摄影。接受验光护理的患者将受益于FA的非侵入性替代品，以改善视网膜疾病的筛查，尤其是在这些不足的社区中。 PC-OCT有可能提供低成本且方便的血管筛查方法，这可能会及时推荐给视网膜专家，并改善视觉结果。为了将PC-OCT作为视网膜成像工具推进，我们有以下目标：（1）将PC-OCT软件开发到更快的自动化平台中，以应用于商业光谱域（SD-OCT）系统； （2）优化光学扫描仪性能，用于成像扩张和非滴定学生； （3）证明了PC-OCT作为糖尿病性视网膜病的宽场筛查诊断的可行性。 PC-OCT成像的可视化功能将直接与眼睛护理专业人员当前的诊断标准直接比较。成功完成II期将导致一个自动软件包，能够从商用SD-OCT系统的原始数据中生成PC-OCT微血管图像，从而使所有眼保健从业者都可以访问方便的血管成像。这可能会导致视网膜疾病的更好质量检测能力，并可能 改进的视觉结果。