Longitudinal Assessment of Manic Symptoms

躁狂症状的纵向评估

• 批准号: 8441603
• 负责人: BORIS BIRMAHER
• 金额: $ 126.56万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-16 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8441603
• 关键词: 17 year old; Academic achievement; Address; Adolescence; Age; Alcohol or Other Drugs use; Amygdaloid structure; Area; Attention deficit hyperactivity disorder; Awareness; Behavior; Biological; Biological Markers; Bipolar Disorder; Brain; Categories; Child; Childhood; Clinical; Collection; Comorbidity; Cyclothymic Disorder; DSM-IV; Data; Deformity; Development; Diagnosis; Diagnostic; Diagnostic and Statistical Manual; Disease; Doctor of Philosophy; Emotional; Emotions; Enrollment; Ensure; Environment; Equipment and supply inventories; Evaluation; Event; Evolution; Face; Family; Family history of; Feeling suicidal; Functional Magnetic Resonance Imaging; Funding; Gender; Glossary; Goals; Growth; IGFBP2 gene; Image; Individual; Informal Social Control; Intervention; Kindling (Neurology); Laboratories; Lead; Learning; Life; Longitudinal Studies; Magnetic Resonance Imaging; Manic; Maps; Measures; Memory; Mental Health Services; Mental disorders; Methods; Modeling; Mood Disorders; Moods; National Institute of Mental Health; Natural History; Neurocognitive; Ohio; Outcome; Parents; Participant; Pediatric Hospitals; Performance; Pharmaceutical Preparations; Phenotype; Predictive Value; Process; Psychiatric Diagnosis; Psychopathology; Puberty; Race; Reaction Time; Recording of previous events; Recruitment Activity; Relapse; Relative (related person); Request for Applications; Research; Research Personnel; Resistance; Risk; Risk Factors; Risk-Taking; Sampling; Severities; Short-Term Course; Site; Specific qualifier value; Strategic Planning; Structure; Subgroup; Suicide attempt; Support System; Symptoms; System; Task Performances; Techniques; Testing; Time; Universities; Youth; aged; base; childhood bipolar disorder; clinical risk; cognitive control; cognitive function; cohort; comparison group; depressive symptoms; effective therapy; emerging adult; emotion regulation; evidence base; evidence based guidelines; executive function; experience; follow-up; functional outcomes; health care service utilization; high risk; improved; innovation; instrument; meetings; neurocognitive test; neuroimaging; psychosocial; public health relevance; relating to nervous system; screening; sex; stressor; success; young adult

DESCRIPTION (provided by applicant): This competing continuation application requests funds to continue the Longitudinal Assessment of Manic Symptoms (LAMS) study at 4-sites. Over the past 3.5 years, using a valid and reliable screening instrument, children ages 6-12 years were identified with elevated symptoms of mania (ESM) at the time of their first clinical presentation. Approximately 621 youth were identified as having ESM. In addtion, 86 age/race/sex matched comparison children without ESM at first clinical presentation were enrolled. During the LAMS study, these participants were evaluated at baseline and every 6 months thereafter. At each assessment point, youths were evaluated regarding their psychiatric diagnoses, psychiatric symptomatology, mental health service utilization, and psychosocial functioning. As part of this competing continuation application (LAMS2), the investigators propose to continue these 6-month evaluations. In addition, LAMS2 will include both neurocognitive testing as well as neuroimaging techniques in order to identify possible biomarkers that reflect or are related to underlying biological mechanisms that predisopose individuals to the development of bipolar disorders. In acordance with the NIMH's Strategic Plan, LAMS2 would focus on examining and documenting trajectories of youths with ESM and related psychiatric disorders in order to better identify crucial timepoints for intervention. More specifically, the goals of LAMS2 include: 1) examining the stability of ESM over time in relation to changes in mood symptoms and DSM-IV-TR criteria for mood disorders; 2) examining the positive predictive value of ESM alone and in combination with other potential risk factors in order to better identify youth who will eventually develop bipolar disorders (BPD) as they progress into and through adolescence; 3) developing evidence-based, atheoretical, diagnostic criteria for a pediatric phenotype for bipolar spectrum disorders; 4) identifying risk factors associated with poor functional outcomes for youth with ESM; 5) examining the relationships between mood episodes and clinical outcomes over time; 6) evaluating neurocognitive performance, together with functional abnormalities in selected neural systems and their relationship to ESM and the development of BPD during youth and early adulthood. The current participants will begin the competitive renewal period ranging in age from 8-17 years. At the end of LAMS2, June 2015, the cohort will range in years from 13-22 years. For this reason, LAMS 2 will provide an opportunity for the collection of innovative and clinically important data during a period of time in which when study participants will have entered an age of high risk for the development of a bipolar spectrum disorder.

描述（由申请人提供）：此竞争性延续申请要求资金继续对躁狂症状进行纵向评估（LAMS）研究。在过去的3.5岁时，使用有效可靠的筛查工具，在第一次临床表现时，发现了6-12岁的儿童，躁狂症（ESM）的症状升高。大约有621名年轻人被确定为具有ESM。另外，首先招募了86岁的年龄/种族/性别匹配的比较儿童，没有ESM。在LAMS研究中，这些参与者在基线和此后每6个月进行评估。在每个评估点，都对年轻人进行了精神诊断，精神症状学，心理健康服务利用和社会心理功能的评估。作为此竞争连续申请（LAMS2）的一部分，研究人员建议继续进行这6个月的评估。此外，LAMS2将包括神经认知测试和神经影像学技术，以确定反映或与潜在的生物学机制相关的可能生物标志物，这些生物学机制使诱发双相情感障碍的生物学机制。 在NIMH的战略计划中，LAMS2将着重于检查和记录患有ESM和相关精神疾病的年轻人的轨迹，以便更好地识别干预的关键时间点。更具体地说，LAMS2的目标包括：1）随着时间的流逝，检查ESM在情绪症状变化和情绪障碍的DSM-IV-TR标准方面的稳定性； 2）检查单独使用ESM的积极预测价值，并与其他潜在的危险因素结合使用，以便更好地识别最终会在进入青春期发展和通过青春期时最终发展双相情感障碍（BPD）的青年； 3）开发针对双相情感障碍的儿科表型的基于证据的，验证的诊断标准； 4）确定与ESM青年的功能不良结果相关的危险因素； 5）检查情绪发作和随着时间的临床结果之间的关系； 6）评估神经认知性能，以及选定神经系统中的功能异常及其与ESM的关系以及在青年和成年初期的BPD的发展。目前的参与者将开始在8-17岁之间开始竞争性更新期。在2015年6月的LAMS2结束时，该队列将在13 - 22年的时间内。因此，LAMS 2将为收集创新和临床重要的数据提供机会，在研究参与者进入双极谱系障碍的高风险时代。