Open Source Microscopy Software

开源显微镜软件

• 批准号: 8554762
• 负责人: RONALD D VALE
• 金额: $ 38.85万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8554762
• 关键词: Academia; Address; Adopted; Advanced Development; Automation; Biomedical Research; Code; Communities; Computer software; Cost Savings; Data; Development; Devices; Documentation; Environment; Equipment; Fiji; Foundations; Grant; Image; Image Analysis; Individual; Industry; Life; Light Microscope; Lighting; Linux; Maintenance; Methods; Microscope; Microscopy; Modification; Nature; Optics; Pain; Procedures; Process; Protocols documentation; Quality Control; Reporting; Research; Research Personnel; Running; Savings; Scientist; Solutions; Source Code; Staging; Stress; Structure; System; Techniques; Time; United States National Institutes of Health; Vendor; Work; Writing; base; cost; design; digital; flexibility; improved; innovation; instrument; light microscopy; meetings; novel; open source; operation; programs; repository; research study; software development; tool; user-friendly

DESCRIPTION (provided by applicant): Modern light microscopes use digital cameras, motorized stages, shutters, filter wheels, etc., that need to be controlled by computer software. Various commercial solutions exists, all of which have shortfalls. The ?Manager software application is open source, freely available software for microscope automation written for and by scientists that runs on Windows, Mac OS X, and Linux. It provides an easy-to-use interface through which most microscope hardware can be controlled making it simple for scientists to carry out experiments using equipment from different vendors. The software is used at about 2000 microscopes world-wide, and provides significant savings to the NIH since individual copies of commercial alternatives cost $5-15k. ?Manager also provides a hardware abstraction layer that is used by scientists with programming abilities to automate their microscope hardware in novel and creative ways. The open source nature of this project not only makes it possible to see exactly how acquisition protocols are carried out (which is important in research), but also attracts many code contributions from industry and academia. Many companies already make sure that their equipment works within ?Manager and maintain the source code for their equipment in the ?Manager source code repository. More than 50 programmers have contributed code, a number that continues to rise. This grant will be used to continue stewardship of these many code contributions, regularly release user-friendly installers for the software, improve documentation, address bug reports, etc. It will also be used to add novel capabilities to the software such as live STORM/PALM imaging, structured illumination-based optical sectioning, and photo-bleaching/photo-activation using digital mirror devices. In addition, integration with existing open source microscopy-related software packages will be improved.

描述（由申请人提供）：现代光学显微镜使用数码相机，电动阶段，百叶窗，过滤轮等，需要由计算机软件控制。存在各种商业解决方案，所有这些都有缺口。 “管理器软件”应用程序是开源的，是为显微镜自动化的免费提供的软件，该软件是为Windows，Mac OS X和Linux上运行的科学家编写的。它提供了一个易于使用的界面，可以通过该界面来控制大多数显微镜硬件，从而使科学家可以简单地使用来自不同供应商的设备进行实验。该软件在全球范围内约为2000个显微镜，并为NIH提供了可观的节省，因为商业替代品的各个副本的价格为$ 5-15k。管理器还提供了具有编程能力的科学家使用的硬件抽象层，以通过新颖和创新的方式自动化其显微镜硬件。该项目的开源性质不仅可以准确了解如何执行采集协议（这在研究中很重要），而且还吸引了行业和学术界的许多代码贡献。许多公司已经确保其设备在管理器中工作，并在“管理器源代码存储库”中维护其设备的源代码。超过50个程序员贡献了代码，这个数字继续增加。该赠款将用于继续管理这些众多代码贡献，定期发布该软件的用户友好安装程序，改进文档，地址错误报告等。它也将用于为软件增加新颖的功能，例如实时风暴/手掌成像，基于结构化照明的光学分段以及使用数字镜像设备的照片散布/照相/照相。此外，将改进与现有的开源显微镜相关软件包的集成。