Developmental Core

发展核心

基本信息

批准号：
8329462
负责人：
Bruce D Rapkin
金额：
$ 96.67万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8329462
关键词：
Action Research Address Adhesions Adult Advisory Committees Algorithms Antineoplastic Agents Appointment Area Arts Attention Behavior Therapy Behavioral Sciences Belief Bioinformatics Biological Markers Biology Biomedical Engineering Biomedical Research Biometry Brain Cancer Biology Caring Cell Cycle Regulation Cell Death Cellular biology Chronic Clinical Trials Cohort Studies Collaborations Communication Communities Community Health Education Community Outreach Computer Simulation Data Decision Making Development Doctor of Philosophy Education and Outreach Epidemiologist Epidemiology Epithelial Evaluation Extravasation Faculty Funding Future Gastroenterology Gene Expression Genetic Genetic Risk Goals Growth Health Housing Human Impaired cognition Improve Access Incidence Individual Individual Differences Institution Intervention Intervention Studies Knowledge Lead Letters Life Style Malignant Neoplasms Mammary Neoplasms Maps Medical Ethics Medicine Memorial Sloan-Kettering Cancer Center Mentors Mentorship Methodology Minority Modeling Molecular Molecular Biology Molecular Chaperones Molecular Genetics Morbidity - disease rate National Institute of Drug Abuse Neoplasm Metastasis Neurocognitive Neurosciences Outcome Patients Pattern Pharmaceutical Preparations Pilot Projects Policies Population Population Genetics Positioning Attribute Preparation Primary Health Care Process Provider Psychiatry Psychologist Psychology Recommendation Recruitment Activity Research Research Personnel Research Proposals Research Support Research Training Resources Risk Role Screening procedure Services Social Medicine Specialist Stress Stress and Coping System Target Populations Therapeutic Therapeutic Clinical Trial To specify Training Training and Education Translational Research Work anticancer research base biopsychosocial cancer cell cancer diagnosis cancer health disparity cancer risk cancer therapy career chemotherapy clinically relevant cohort community intervention dissemination research expectation experience falls genetic epidemiology graduate student health disparity health economics improved infrastructure development inhibitor/antagonist interest meetings member oncology outreach outreach program professor progenitor programs psychosocial reconstitution resilience response senescence simulation skills smoking cessation sociologist symposium

项目摘要

8. Developmental Core The following sections describe our major developmental activities over the next five years. 8.a. Faculty Recruitment Establishing Priorities for Faculty Recruitment: Early in our U54 Planning Process, we formed a Task Force to begin to map out topics that we would include in our Transdisciplinary Health Disparities Research Focus. The Task Force on Transdisciplinary Health Disparities Research that met in the summer and fall of 2006 included: ¿ Timothy Ahles, MSKCC Psychiatry ¿ David Lounsbury, MSKCC Behavioral Sciences ¿ Mary Alpaugh, CCNY Biology ¿ Sara Olson, MSKCC Epidemiology ¿ Carol Brown, MSKCC Gynecological Oncology ¿ Lucas Parra, CCNY Biomedical Engineering ¿ Jack Burkhalter, MSKCC Behavioral Sciences ¿ Bruce Rapkin, MSKCC Behavioral Sciences ¿ Karen Hubbard, CCNY Biology ¿ Manish Shah, MSKCC Gastroenterology ¿ Edward Keller, CCNY Media and ¿ Ann Marie Yali, CCNY Psychology Communication Arts ¿ Anne Zauber, MSKCC Epidemiology ¿ Yuelin Li, MSKCC Psychiatry and Biostatistics This Task Force generated themes described below. Each of these themes was identified as an area of priority by investigators at one or both institutions. In some instances, we do not have faculty partners identified who are working in a given area at both institutions. However, through regular symposia and on-going planning, we will develop recommendations for continuing development in each of these areas: Community-Based Intervention and Dissemination Research Neurocognitive Impacts of Cancer Therapeutics Participatory Research and the Identification of Biomarkers and Genetic Risks Increasing the Diversity of Patients on Cancer Clinical Trials Biopsychosocial Research on Stress Mathematical Modeling and Simulation of Psychosocial and Behavioral Interventions U54 Implementation and Faculty Search U54 Funds Allocated for Cancer Biology Professor 8.b. Proposed Pilot Projects Six pilot research proposals (Projects 2-7) are included after this narrative. These projects are highly responsive to Partnership objectives as well as future directions. Fu and Giancotti propose a basic study to examine adhesion and extravasation of mammary tumors, a line of research that will help to explain mechanisms of metastasis (Project 4). Two of the projects have strong potential for clinical relevance: Pezzano and Sant'Angelo's study of the potential for thymic epithelial progenitors to reconstitute of thymic function after HSCT (Project 6) and Wang and Jiang's work on screening anti-cancer agents Project 7). Two additional pilot projects emphasize the untapped potential to address cancer health disparities in that community-based primary care practices. Ostroff and Lubetkin examine whether patient navigators can enhance and extend providers' efforts to encourage patients to quit smoking (Project 5). Weiss and Binz-Sharf want to provide primary care doctors with knowledge and skills to help their patients understand and consider therapeutic clinical trials after a cancer diagnosis (Project 3). Hubbard, Ahles and Ragnauth's study grew out of our Task Force on Transdisciplinary Research, to examine genetic damage associated with chemotherapy induced cognitive decline (Project 2). Two of these pilot teams (Fu/Giancotti and Pezzano/Sant'Angelo) have long standing collaborations. Both teams have been successful in obtaining outside support based on their Us6 pilots. These pilots are different from these teams' earlier work, and logical next steps in productive lines of research. 8.c. Proposed Full Project Our full project (Project i) grows out of the productive collaboration of our two senior investigators: Avrom Caplan and Neal Rosen. This team proposes a study to examine the use of Hsp9O molecular chaperone inhibitors to promote cancer cell death. Their project supports the Partnership's objective to carry out translational research in cell biology to support advances in cancer treatment. 8.d. Proposed Resource/Infrastructure Development Training and Education Outreach

8. 发展核心以下各节描述了我们未来五年的主要发展活动。 8.a. 教师招聘确定教师招聘的优先顺序：在 U54 规划流程的早期，我们成立了一个工作组来开始规划我们将要实施的主题纳入我们的跨学科健康差异研究重点。 2006 年夏季和秋季举行的健康差异研究包括： ¿ Timothy Ahles，MSKCC 精神病学 ¿ David Lounsbury，MSKCC 行为科学 ¿ Mary Alpaugh，CCNY 生物学 ¿萨拉·奥尔森 (Sara Olson)，MSKCC 流行病学 ¿ Carol Brown，MSKCC 妇科肿瘤科 ¿ Lucas Parra，CCNY 生物医学工程 ¿ Jack Burkhalter，MSKCC 行为科学 ¿ Bruce Rapkin，MSKCC 行为科学 ¿凯伦·哈伯德 (Karen Hubbard)，CCNY 生物学 ¿ Manish Shah，MSKCC 胃肠病学 ¿爱德华·凯勒 (Edward Keller)，CCNY 媒体和 ¿ Ann Marie Yali，CCNY 心理学传播艺术 ¿ Anne Zauber，MSKCC 流行病学 ¿李跃琳，MSKCC 精神病学和生物统计学该工作组生成了如下所述的主题，每个主题都被确定为一个领域。在某些情况下，我们没有教师合作伙伴。然而，通过定期研讨会和会议，确定了两个机构在特定领域工作的人员。在持续规划中，我们将为这些领域的持续发展提出建议：基于社区的干预和传播研究癌症治疗对神经认知的影响参与性研究以及生物标志物和遗传风险的识别增加癌症临床试验患者的多样性关于压力的生物心理社会研究心理社会和行为干预的数学建模和模拟 U54实施和教师搜索 U54 为癌症生物学教授分配的资金 8.b. 拟议的试点项目本叙述后包括六个试点研究提案（项目 2-7）。这些项目非常重要。 Fu 和 Giancotti 提出了一项基础研究，以响应合作伙伴的目标和未来的方向。检查乳腺肿瘤的粘附和外渗，一系列研究将有助于解释转移机制（项目 4）。其中两个项目具有很强的临床相关性潜力： Pezzano 和 Sant'Angelo 对胸腺上皮祖细胞重建的潜力的研究 HSCT后的胸腺功能（项目6）以及Wang和Jiang的抗癌药物筛选工作项目 7)。另外两个试点项目强调了解决癌症健康问题的未开发潜力。奥斯特罗夫和卢贝特金研究了基于社区的初级保健实践是否存在差异。患者导航器可以加强和扩大提供者鼓励患者戒烟的努力（项目 5）Weiss 和 Binz-Sharf 希望为初级保健医生提供知识和技能帮助患者了解并考虑癌症诊断后的治疗性临床试验（项目 3）。哈伯德、阿勒斯和拉格瑙斯的研究源于我们的跨学科研究工作组，旨在检查与化疗引起的认知能力下降相关的遗传损伤（项目 2）。这些试点团队（Fu/Giancotti 和 Pezzano/Sant'Angelo）都有长期合作。团队已经成功地根据他们的 US6 飞行员获得了外部支持。与这些团队早期的工作不同，以及研究生产线上合乎逻辑的后续步骤。 8.c. 拟议的完整项目我们的整个项目（项目 i）源于我们两位高级研究人员富有成效的合作： Avrom Caplan 和 Neal Rosen 该团队提出了一项研究 Hsp9O 分子的用途。他们的项目支持该伙伴关系的目标：开展细胞生物学转化研究，以支持癌症治疗的进步。 8.d. 拟议的资源/基础设施开发培训和教育外展