EIT: a non-radiating functional imaging method for cystic fibrosis

EIT：囊性纤维化的非辐射功能成像方法

• 批准号: 8638305
• 负责人: Jennifer Lynn Mueller
• 金额: $ 21.78万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8638305
• 关键词: Acute; Admission activity; Adult; Adverse effects; Aftercare; Air; Algorithms; Antibiotic Therapy; Antibiotics; Atelectasis; Body Surface; Child; Chronic lung disease; Cities; Clinical; Computer software; Cystic Fibrosis; Data; Diagnosis; Effectiveness; Electrodes; Exposure to; Feedback; Frequencies; Functional Imaging; Goals; Gold; Hospitalization; Image; Imaging Techniques; Imaging technology; Individual; Ionizing radiation; Knowledge; Longevity; Lung; Measures; Mucous body substance; Nature; Obstruction; Oral; Patient Care; Patient Outcomes Assessments; Patients; Positioning Attribute; Pulmonary Function Test/Forced Expiratory Volume 1; Pulmonary function tests; Radiation; Research; Risk; Sedation procedure; Sensitivity and Specificity; Side; Spirometry; Surveys; Symptoms; System; Technology; Testing; Time; Venous; X-Ray Computed Tomography; cystic fibrosis patients; electric impedance; experience; imaging modality; improved; infancy; interest; lung imaging; public health relevance; reconstruction; software systems; tomography; voltage

Project Summary Individuals with chronic lung disease often have conditions that are very dicult to diagnose without the aid of imaging technology. The gold standard, CT scanning, exposes the patient to ionizing radiation and may be harmful in children. Electrical impedance tomography (EIT) is a noninvasive, non-ionizing functional imaging technique in which electrodes are placed on the surface of the body, and low amplitude, low frequency current is applied on the electrodes. This results in a voltage distribution on the electrodes which can then be measured. From these voltages, an image is formed that re ects the conductivity and/or permittivity distribution within the region of interest. Since EIT is a safe and portable technology with no damaging side e ects, it can be used as needed. This project is part of a long term goal to develop an EIT system for imaging patients with chronic lung disease. The goal of this research is to determine whether electrical impedance tomography can provide a means to obtain quantitative and regional information about the extent and nature of bronchial obstruction in patients with cystic brosis (CF). In particular, EIT will be used to identify regions of obstruction (air trapping) and consolidation comprised of atelectasis and airway occlusion in CF patients, and to correlate these measures with improvements seen after hospitalized treatment for a pulmonary exacerbation. The rst speci c aim is to develop algorithms for quantifying bronchial obstruction and consolidation and to determine their sensitivity and speci city. The algorithms will extract information from EIT images of conductivity and permittivity computed using the D-bar reconstruction algorithm developed by the P.I. Data will be collected during spirometry on CF patients clinically indicated for CT scans and on subjects with healthy lungs, and the sensitivity and speci city of the algorithms will be determined using both the data from the healthy subjects and data calculated from CT VIDA Software. The second speci c aim is to determine whether these algorithms can demonstrate the bene cial e ects of antibiotic treatment for CF patients with an acute PE by correlating changes in quantitative EIT measures with clinical measures known to improve following therapy, with patients serving as their own controls. Regional changes in air trapping and consolidation from pre to post treatment as indicated by the EIT images will be calculated, with subjects serving as their own control.

项目摘要 患有慢性肺部疾病的人通常具有非常可诊断的条件 没有成像技术的帮助。黄金标准，CT扫描，使患者暴露于 电离辐射，可能对儿童有害。电阻抗断层扫描（EIT）是 非侵入性非电源功能成像技术，其中电极放在表面上 身体和低振幅的低频电流施加在电极上。这结果 在电极上的电压分布中，然后可以测量。从这些电压中， 形成图像，以重新赋予在该区域内的电导率和/或介电常数分布 兴趣。由于EIT是一项安全且便携式的技术，没有破坏性的侧面ects，因此可以使用它 根据需要。该项目是开发用于成像患者的EIT系统的长期目标的一部分 患有慢性肺部疾病。 这项研究的目的是确定电阻抗断层扫描是否可以提供 获取有关支气管范围和性质的定量和区域信息的手段 囊性肿瘤患者（CF）的阻塞。特别是，EIT将用于识别区域 CF中的肺不张和气道阻塞的阻塞（空气捕获）和巩固 患者，并将这些措施与住院治疗后看到的改善相关联 肺部恶化。第一个特定的目的是开发用于量化支气管的算法 阻塞和巩固，并确定其敏感性和特定城市。算法将 从使用D-bar计算的电导率和介电常数的EIT图像中提取信息 P.I.开发的重建算法在CF上的肺活量测定法期间将收集数据 临床表明CT扫描和患有健康肺的受试者的患者以及灵敏度 和算法的特定城市将使用来自健康受试者的两个数据确定 以及根据CT VIDA软件计算的数据。第二个特定目的是确定是否 这些算法可以证明针对CF患者的抗生素治疗的好处 通过将定量EIT度量的变化与已知的临床措施相关的急性PE 为了改善治疗后，患者作为自己的对照。空气区域变化 如EIT图像所示，从前到治疗后的捕获和整合将是 计算，主题是自己的控制。