Tri National Training Program in Psychiatric Genetics

国家精神科遗传学培训计划

• 批准号: 8531367
• 负责人: Hader A. Mansour
• 金额: $ 10.36万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-08 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531367
• 关键词: Caucasians; Caucasoid Race; Chromosome Mapping; Chronic; Chronic Disease; Comorbidity; Complement; Complex; Coronary Arteriosclerosis; Country; Data Set; Developed Countries; Developing Countries; Disease; Doctor of Philosophy; Educational workshop; Egypt; Epidemiology; Faculty; Genetic; Genetic Predisposition to Disease; Health; India; Institution; Learning; Link; Mental disorders; Morbidity - disease rate; Obesity; Pathogenesis; Population; Problem Solving; Psychiatry; Research; Research Infrastructure; Research Personnel; Research Training; Role; Sampling; Schizophrenia; Site; Source; Training; Training Programs; Training and Infrastructure; Universities; infrastructure development; medical specialties; novel; psychogenetics; symposium

DESCRIPTION (provided by applicant): Our training program will focus on the genetics of schizophrenia (SZ) and bipolar I disorder (BPrincipal Investigator). Our training will occur primarily in India and Egypt, which have a combined population of over 1.2 billion. SZ and BPrincipal Investigator are common and substantial sources of morbidity world-wide, yet their treatment is unsatisfactory. SZ and BPrincipal Investigator may share etiological factors and manifest co-morbidity with several prevalent chronic disorders, such as obesity and coronary artery disease. All these diseases have a proven genetic etiology, with complex inheritance. Successful gene mapping efforts will require large samples. Such samples are difficult to ascertain in developed countries and are largely restricted to Caucasians. Such recruitment is more feasible in developing countries. Indeed, novel etiological factors may be present. Parallel studies in developing and developed countries may also clarify the role of genetic factors against diverse environmental backgrounds. Such research has lagged in developing countries. We have established productive psychiatric genetic studies at four collaborating sites in India, Egypt and at the University of Pittsburgh (PITT). Training / research infrastructure building have also been initiated. This proposal adds two more sites. We will continue training linked to ongoing research, each activity complementing the other. There are two components: (1) The primary component is doctoral (PhD) training for six candidates who will exploit and extend our rich dataset. The training will occur primarily at the overseas institutions, with complementary training at PITT. PITT faculty will actively supervise the trainees and train local faculty as needed. (2) We will organize three specialty training workshops and public symposia at the overseas sites. We will thus provide infrastructure development, extend our gene mapping efforts and facilitate interactive learning and problem solving among the tri-national collaborators. The present proposal will lay the groundwork for a tradition of collegial training and research in two large countries where psychiatric disorders are common, but are stigmatized. PUBLIC HEALTH RELEVANCE: Treatment and research for schizophrenia and bipolar I disorder are important unmet needs in India and Egypt. We will continue training, infrastructure development and extend genetic epidemiological research already initiated by us. Thus we will enhance research in both psychiatry and genetics. The research will directly benefit the USA, by helping understand the pathogenesis of two common, severe, chronic, disabling disorders.

描述（由申请人提供）：我们的培训计划将重点关注精神分裂症（SZ）和双相情感障碍（Bprincipal研究者）的遗传学。我们的培训将主要发生在印度和埃及，总人口超过12亿。 SZ和Bprincipal研究者是全球发病率的常见和实质性的来源，但他们的治疗却不令人满意。 SZ和Bprincipal研究者可能会与病因，并与几种流行的慢性疾病（例如肥胖症和冠状动脉疾病）共享病因。所有这些疾病具有良好的遗传病因，具有复杂的遗传。成功的基因映射工作将需要大量样本。在发达国家，这种样本很难确定，并且在很大程度上仅限于高加索人。在发展中国家，这种招聘更为可行。实际上，新型的病因可能存在。在发展中国家和发达国家中的平行研究也可以阐明遗传因素在各种环境背景下的作用。这样的研究滞后于发展中国家。我们已经在印度，埃及和匹兹堡大学（PITT）的四个合作场所建立了生产性精神遗传研究。还启动了培训 /研究基础设施建设。该提案增加了两个站点。我们将继续与正在进行的研究相关的培训，每项活动都补充彼此。有两个组成部分：（1）主要组成部分是博士（博士学位）培训六个候选人，这些候选人将利用和扩展我们丰富的数据集。培训将主要在皮特（Pitt）进行补充培训，主要是在海外机构进行。皮特教师将根据需要积极监督学员并培训当地教师。 （2）我们将在海外网站组织三个专业培训研讨会和公共专题讨论会。因此，我们将提供基础设施的发展，扩展基因映射工作，并促进三国合作者之间的互动学习和解决问题。本提案将在两个大国常见但被污名化的两个大国的大学培训和研究的传统奠定基础。公共卫生相关性：精神分裂症和双相情感障碍的治疗和研究是印度和埃及的重要未满足需求。我们将继续培训，基础设施发展，并扩展我们已经启动的遗传流行病学研究。因此，我们将增强精神病学和遗传学的研究。这项研究将通过帮助了解两种常见，严重，慢性，致残性疾病的发病机理直接受益于美国。

项目成果

Protocol to evaluate the impact of yoga supplementation on cognitive function in schizophrenia: a randomised controlled trial.

• DOI: 10.1017/neu.2014.9
• 发表时间: 2014-10
• 期刊: ACTA NEUROPSYCHIATRICA
• 影响因子: 3.8
• 作者: Bhatia, Triptish;Mazumdar, Sati;Mishra, Nagendra Narayan;Gur, Raquel E.;Gur, Ruben C.;Nimgaonkar, Vishwajit Laxmikant;Deshpande, Smita Neelkanth
• 通讯作者: Deshpande, Smita Neelkanth