Discovery of Natural Product based Drugs and Bioenergetic Materials from CR

从 CR 中发现基于天然产物的药物和生物能材料

• 批准号: 8488515
• 负责人: DAVID H SHERMAN
• 金额: $ 80.66万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-11 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8488515
• 关键词: Actinobacteria class; Address; Anabolism; Area; Bacteria; Biodiversity; Bioenergetics; Bioinformatics; Biological Factors; Carboxy-Lyases; Cellulases; Chemicals; Collaborations; Collection; Core Facility; Costa Rica; Costa Rican; Country; Coupled; Cyanobacterium; DNA; DNA Sequence; DNA Sequencing Facility; Data; Decarboxylation; Development; Disease; Economic Development; Economics; Educational workshop; Engineering; Environment; Enzymes; Equipment and supply inventories; Genetic; Genome; Genome Scan; Genomics; Habitats; Health; Human; Hydrocarbons; Hydrolase; Hydrolysis; Infectious Agent; Insecta; Institutes; International; Invertebrates; Joints; Lead; Libraries; Link; Liquid substance; Malaria; Maps; Marine Invertebrates; Marine Sediment; Marines; Metabolic; Methods; Michigan; Microbe; Microbiology; Modification; Myxococcales; Nerve Degeneration; Oxidoreductase; Pathway interactions; Pharmaceutical Preparations; Pharmacologic Substance; Phylogenetic Analysis; Production; Research; Resource Sharing; Resources; Scientist; Sequence Analysis; Source; Structure; Students; System; Testing; Therapeutic Agents; Training; Transcription Factor AP-1; Transcription Factor AP-2 Alpha; United States National Institutes of Health; Universities; Viral; Visit; Water; Work; base; benefit sharing; cancer cell; cellulase; high throughput screening; improved; isoprenoid; medical schools; metabolic engineering; meter; microbial; microbial alkaline proteinase inhibitor; microorganism; next generation; pathogen; pre-clinical research; programs; rRNA Genes; screening; sugar; thioester; tool

DESCRIPTION (provided by applicant): The International Biodiversity Conservation Group (ICBG) program links three key issues, including human health, biodiversity conservation, and economic development by encouraging programs in the U.S. and programs in countries with high biodiversity to form integrated research teams. The ICBG described in this application involves programs located in the U.S. and Costa Rica that will cooperate to: Improve human health through the discovery of bioactive natural products from Costa Rica's rich biodiversity using ecologically-driven approaches. Contribute to the development of a bioenergy program toward discovery of cellulases and other enzymes for applications in biofuel production. Focus natural product and biosynthetic enzyme-related research on unexplored and under-explored microorganisms such as marine bacteria and insect microbial endosymbionts. Improve the research capacity and economic opportunities for Costa Rica and contribute to its National Biodiversity Strategy through gathering data for its biodiversity inventory, intensive screening of its natural products in medically relevant assays, high throughput testing of its hydrolytic enzymes, sharing of resources, clear benefit-sharing, and training of students and visiting scientists. These broad aims will be pursued through three Associate Programs located both in Costa Rica at the National Institute of Biodiversity (INBio), and the U.S. at Harvard Medical School (HMS) and the University of Michigan (U-M). The Associate Programs will conduct the pre-clinical research to discover, isolate, evaluate and develop therapeutic agents from natural products. Their collection programs, which will be coupled with genetic and phenotypic analyses, will expand Costa Rica's biodiversity inventory for microorganisms. Workshops and scientific exchanges will provide training opportunities. A bioenergy research program on sugar hydrolase discovery and commercial development is proposed as well as a program to harness enzymes from natural product biosynthesis (e.g., thioester hydrolases and decarboxylases) with application in liquid fuel production (biodiesel).

描述（由申请人提供）：国际生物多样性保护组织（ICBG）计划通过鼓励美国的项目和生物多样性丰富的国家的项目组建综合研究团队，将人类健康、生物多样性保护和经济发展等三个关键问题联系起来。本申请中描述的 ICBG 涉及位于美国和哥斯达黎加的项目，这些项目将合作： 通过使用生态驱动的方法从哥斯达黎加丰富的生物多样性中发现生物活性天然产品，改善人类健康。促进生物能源计划的发展，以发现纤维素酶和其他酶在生物燃料生产中的应用。将天然产物和生物合成酶相关的研究重点放在未探索和探索不足的微生物（如海洋细菌和昆虫微生物内共生体）上。提高哥斯达黎加的研究能力和经济机会，并通过收集其生物多样性清单数据、在医学相关分析中对其天然产物进行密集筛选、对其水解酶进行高通量测试、资源共享、明确效益，为其国家生物多样性战略做出贡献-学生和访问科学家的分享和培训。这些广泛的目标将通过位于哥斯达黎加国家生物多样性研究所 (INBio) 以及美国哈佛医学院 (HMS) 和密歇根大学 (U-M) 的三个副项目来实现。副计划将进​​行临床前研究，以从天然产物中发现、分离、评估和开发治疗剂。他们的收集计划将与遗传和表型分析相结合，将扩大哥斯达黎加的微生物生物多样性库存。讲习班和科学交流将提供培训机会。提出了一项关于糖水解酶发现和商业开发的生物能源研究计划，以及一项利用天然产物生物合成酶（例如硫酯水解酶和脱羧酶）应用于液体燃料生产（生物柴油）的计划。

项目成果

Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp.

• DOI: 10.1021/np9005597
• 发表时间: 2009-11
• 期刊: JOURNAL OF NATURAL PRODUCTS
• 影响因子: 5.1
• 作者: Carlson, Jacob C.;Li, Shengying;Burr, Douglas A.;Sherman, David H.
• 通讯作者: Sherman, David H.

New naphthoquinones and a new δ-lactone produced by endophytic fungi from Costa Rica.

• DOI: 10.1016/j.tetlet.2010.11.159
• 发表时间: 2011-04-27
• 期刊: TETRAHEDRON LETTERS
• 影响因子: 1.8
• 作者: Cao, Shugeng;Clardy, Jon
• 通讯作者: Clardy, Jon

Asterogynins: secondary metabolites from a Costa Rican endophytic fungus.

• DOI: 10.1021/ol101972g
• 发表时间: 2010-10-15
• 期刊: ORGANIC LETTERS
• 影响因子: 5.2
• 作者: Cao, Shugeng;Ross, Leila;Tamayo, Giselle;Clardy, Jon
• 通讯作者: Clardy, Jon

Codinaeopsin, an antimalarial fungal polyketide.

• DOI: 10.1021/ol801726k
• 发表时间: 2008-09-18
• 期刊: ORGANIC LETTERS
• 影响因子: 5.2
• 作者: Kontnik, Renee;Clardy, Jon
• 通讯作者: Clardy, Jon

Study of the diversity of culturable actinomycetes in the North Pacific and Caribbean coasts of Costa Rica.

• DOI: 10.1007/s10482-009-9337-4
• 发表时间: 2009-06
• 期刊: ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
• 影响因子: 2.6
• 作者: Solano, Godofredo;Rojas-Jimenez, Keilor;Jaspars, Marcel;Tamayo-Castillo, Giselle
• 通讯作者: Tamayo-Castillo, Giselle