Training Program on HIV Diversity and Drug Resistance-Enhancing Research Capacity

艾滋病毒多样性和增强耐药性研究能力培训计划

• 批准号: 8516302
• 负责人: Phillipe N Nyambi
• 金额: $ 27.6万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8516302
• 关键词: Address; Antiretroviral drug resistance; Biometry; Cameroon; Computer Analysis; Country; Data; Detection; Diagnosis; Diagnostic; Drug resistance; Educational workshop; Epidemiology; Evolution; Genetic Variation; Goals; Grant; HIV; HIV-1; Immunologics; Infection; Laboratories; Medical; Mentors; Molecular Biology; Monitor; New York; Postdoctoral Fellow; Prevention; Prevention program; Property; Research; Research Training; Testing; Training; Training Programs; Variant; Viral; Work; Writing; design; genetic evolution; improved; intervention program; new technology; pre-doctoral; programs; quality assurance; resistance mutation; resistant strain; skills; virus genetics

Project Summary /Abstract The broad HIV-1 genetic diversity and the emergence of drug resistant variants in Cameroon adds to complicate the viral genetic diversity and poses potential problems for diagnosis and prevention efforts, requiring that the evolution of HIV-1 diversity be monitored, and that new HIV-1 variants be examined for sensitivity of detection by different HIV-1 test kits. These problems continue to underscore the need for further training and research in Cameroon. This training program entitled "Training Program on HIV Diversity and Drug Resistance: enhancing research capacity" is designed with long-term to build and strengthen research capacity at the Medical Diagnostic Center in Yaounde, Cameroon for conducting studies to 1) document and monitor HIV-1 genetic diversity and evolution; 2) document and monitor the emergence antiretroviral drug resistant HIV-1 variants; 3) study the biologic and immunologic properties of different HIV-1 variants including emerging and drug resistant strains; 4) monitor the ability of commercially available test kits to diagnose infections by caused by diverse HIV-1 strains; and 5) to improve quality assurance and laboratory biosafety. To achieve these objectives we will: a) Organize in-country training workshops that will provide short-term local onsite training on: i) quality assurance and laboratory biosafety; ii) new technologies and commercially available test kits for the diagnosis of infections caused by diverse HIV strains; and iii) scientific and grant writing skills. b) Provide long-term training in New York for studies of molecular biology/epidemiology/biostatistics relevant to studies of HIV genetic diversity through non-degree or degree programs for pre- and post-doctoral fellows. c) Provide medium-term training in New York for fellows to perform hands-on-laboratory training on viral genetic subtype characterization and computational analysis to document and identify diverse HIV-1 strains and/or drug resistance mutations, and viral biologic and immunologic properties. d) Provide short-term training through hands-on-training in documenting drug resistance mutations and data interpretation, to attend courses on epidemiology and biostatistics and to work one-on-one with relevant mentors. And, e) To support in-country research by providing small grants to appropriate long-term "alumni" fellows to conduct studies that addresses the research goals of the MDC. This training program should build and strengthen the research capacity at MDC to conduct studies on HIV-1 diversity and drug resistance that are relevant to intervention and prevention programs in Cameroon.

项目概要/摘要 喀麦隆广泛的 HIV-1 遗传多样性和耐药变异的出现增加了 使病毒遗传多样性复杂化，给诊断和预防工作带来潜在问题， 要求监测 HIV-1 多样性的演变，并检查新的 HIV-1 变体 不同 HIV-1 检测试剂盒检测的灵敏度。这些问题继续强调需要进一步 在喀麦隆进行培训和研究。此次培训项目题为“艾滋病毒多样性和毒品问题培训项目” 阻力：增强研究能力”旨在长期建设和增强研究能力 在喀麦隆雅温得医学诊断中心进行研究以 1) 记录和监测 HIV-1遗传多样性和进化； 2) 记录并监测抗逆转录病毒药物耐药性的出现 HIV-1 变种； 3) 研究不同HIV-1变种的生物学和免疫学特性，包括新出现的HIV-1变种 和耐药菌株； 4) 监测市售检测试剂盒诊断感染的能力 由多种 HIV-1 毒株引起； 5) 提高质量保证和实验室生物安全。 为了实现这些目标，我们将： a) 组织国内培训研讨会，提供短期本地培训 现场培训： i) 质量保证和实验室生物安全； ii) 新技术和商业 用于诊断不同艾滋病毒株引起的感染的可用检测试剂盒； iii) 科学和资助 写作技巧。 b) 在纽约提供分子研究的长期培训 通过非学位或学位与艾滋病毒遗传多样性研究相关的生物学/流行病学/生物统计学 博士前和博士后研究员计划。 c) 在纽约为研究员提供中期培训 进行病毒遗传亚型表征和计算分析的实验室实践培训，以 记录和识别不同的 HIV-1 毒株和/或耐药突变，以及病毒生物学和 免疫学特性。 d) 通过记录药物的实践培训提供短期培训 耐药突变和数据解释，参加流行病学和生物统计学课程并工作 与相关导师一对一。并且，e) 通过提供小额赠款来支持国内研究 合适的长期“校友”研究员进行研究，以实现 MDC 的研究目标。这 培训计划应建立和加强 MDC 开展 HIV-1 研究的研究能力 与喀麦隆的干预和预防计划相关的多样性和耐药性。