Genetic and Molecular Approaches To Cardiovascular Disease

心血管疾病的遗传和分子方法

• 批准号: 8496863
• 负责人: RONALD M KRAUSS
• 金额: $ 21.03万
• 依托单位: CHILDREN'S HOSPITAL & RES CTR AT OAKLAND
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8496863
• 关键词: Cardiovascular Diseases; Molecular Genetics

DESCRIPTION (provided by applicant): This proposal stems from a long-standing NHLBI-funded post-doctoral training program based at the Lawrence Berkeley National Laboratory that has evolved over time to maintain focus on the most cutting edge topics in cardiovascular research, and has trained many scientists with a wide range of backgrounds who have been actively recruited by academia as well as industry. The leadership and management of this multidisciplinary program will move to Children's Hospital Oakland Research Institute, and it will retain some of the original faculty from the Lawrence Berkeley National Laboratory. A major emphasis of the training is the use of genomic technologies to investigate mechanisms involved in atherosclerotic cardiovascular disease. The eight program mentors each run successful and well-funded laboratories, and bring varied and complementary expertise in cellular, molecular, biophysical, computational, genetic, and genomic aspects of lipoprotein metabolism, atherogenesis and cardiovascular biology. We offer training in state-of-the art areas such as manipulation the genomes of mice, next-generation sequencing, computational analysis of sequence data, analysis of genetic association, computational analysis of human sequence variation to predict its potential role in disease, gene expression profiling, and epigenetics, as well as biophysical studies of lipoprotein structure. In addition, there is strong emphasis on genomic approaches to study gene regulation with a focus on the cardiovascular system and on resequencing and genotyping to identify human sequence variation responsible for cardiovascular disorders. Our location within a major research institution and in close proximity to the University of California, Berkeley creates a rich training environment with potential for numerous collaborations and training opportunities beyond the scope of this grant. The cross- disciplinary training that the trainees receive will provide them with the skills to develop independent research programs that exploit the experimental and computational approaches required for modern biomedical research. RELEVANCE (See instructions): This proposal supports the training of the next generation of scientist who will understand the genetic and biochemical basis of cardiovascular disease.

描述（由申请人提供）： 该提案源于劳伦斯·伯克利国家实验室（Lawrence Berkeley National Laboratory）的一项长期以来由NHLBI资助的博士后培训计划，该计划随着时间的流逝而发展，以保持关注心血管研究中最前端的主题，并培训了许多科学家，并培训了许多具有广泛背景的科学家，这些科学家已被学院积极招募。该跨学科计划的领导和管理将搬到奥克兰研究所儿童医院，并将保留劳伦斯·伯克利国家实验室的一些原始教师。训练的主要重点是使用基因组技术来研究涉及动脉粥样硬化心血管疾病的机制。八个计划的指导者各自开展成功且资金良好的实验室，并在细胞，分子，生物物理，计算，遗传和基因组方面具有多样化和互补的专业知识，脂蛋白代谢，动脉粥样硬化和心血管生物学。我们提供在最新领域（例如操纵小鼠的基因组，下一代测序，序列数据的计算分析，遗传关联分析，人类序列变化的计算分析），以预测其在疾病中的潜在作用，基因表达分析和表观遗传学以及Lipopropoprototein结构的生物物理研究。此外，重点是研究基因调节的基因组方法，重点是心血管系统以及重新配置和基因分型，以鉴定负责心血管疾病的人类序列变异。我们在一家主要的研究机构中的位置，靠近加利福尼亚大学，伯克利分别创造了丰富的培训环境，并有可能获得众多合作和培训机会，这是本赠款范围之外的范围。学员接受的跨学科培训将为他们提供开发独立研究计划的技能，以利用现代生物医学研究所需的实验和计算方法。相关性（请参阅说明）：该提案支持培训下一代科学家，他们将了解心血管疾病的遗传和生化基础。