Genetic Epidemiology and Biostatistics Core

遗传流行病学和生物统计学核心

• 批准号: 8249127
• 负责人: Hemant K. Tiwari
• 金额: $ 16.54万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8249127
• 关键词: Address; Alabama; Biostatistics Core; Candidate Disease Gene; Chromosomes, Human, Pair 4; Clinical; Collection; Data; Data Analyses; Data Base Management; Data Collection; Data Storage and Retrieval; Development; Epidemiology; Evaluation; Experimental Designs; Faculty; Family member; Genes; Genetic; Genome; Goals; Individual; Investigation; Linkage Disequilibrium; Literature; Methods; Patients; Phenotype; Predisposition; Preparation; Procedures; Program Research Project Grants; Publishing; Quality Control; Research; Research Personnel; Risk Factors; Statistical Methods; Systemic Lupus Erythematosus; Universities; Writing; base; data management; epidemiologic data; forest; genetic analysis; genetic epidemiology; medical schools; meetings; novel; programs

The Genetic Epidemiology and Biostatistics Core combines the expertise in genetic analysis of Wake Forest University School of Medicine and the University of Alabama at Birmingham. The Core will continue to guide the experimental design for collection of clinical and genetic data. The Core will continue to offer expertise in data management, statistical and genetic data analysis. The goals of the Genetic Epidemiology and Biostatistics Core are to (1) provide appropriate experimental designs tailored to address specific genetic and epidemiologic hypotheses, (2) facilitate efficient data collection procedures for preparation of data analysis, (3) refine regions of susceptibility using linkage disequilibrium and association methods, and (4) utilize and, in some cases, develop novel methods for analysis of SLE phenotypes. The long-term goals of the Genetic Epidemiology and Biostatistics Core are to utilize genetic and epidemiologic data collected on SLE patients and their family members in order to identify genetic and epidemiologic risk factors that contribute to the susceptibility for SLE. A detailed plan to assure that the Core is successful in meeting its objectives is described.

遗传流行病学和生物统计学核心结合了 Wake 遗传分析的专业知识 森林大学医学院和阿拉巴马大学伯明翰分校。核心将继续 指导收集临床和遗传数据的实验设计。核心将继续提供 数据管理、统计和遗传数据分析方面的专业知识。遗传流行病学的目标 和生物统计学核心是（1）提供适当的实验设计来解决特定的问题 遗传和流行病学假设，(2) 促进有效的数据收集程序，以准备 数据分析，(3) 使用连锁不平衡和关联方法细化易感性区域，以及 (4) 利用并在某些情况下开发新方法来分析 SLE 表型。 遗传流行病学和生物统计学核心的长期目标是利用遗传和生物统计学 收集 SLE 患者及其家庭成员的流行病学数据，以确定遗传和 导致 SLE 易感性的流行病学危险因素。详细的计划，以确保核心 描述了成功实现其目标。