PRENATAL ALCOHOL IN SUDDEN INFANT DEATH SYNDROME AND STILLBIRTH (PASS)

婴儿猝死综合症和死产中的产前饮酒（通过）

基本信息

批准号：
8527614
负责人：
Hendrik Johannes Odendaal
金额：
$ 118.17万
依托单位：
STELLENBOSCH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-30 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8527614
关键词：
Abbreviations Adverse effects Affect Alcohols American Indians Anxiety Autopsy Biological Neural Networks Brain Brain Stem Cerebral cortex Child Clinical Cognitive Collaborations Color Communities Complex Data Data Analyses Data Coordinating Center Development Developmental Biology Disadvantaged Dysmorphology Electroencephalography Enrollment Environmental Risk Factor Ethanol toxicity Face Failure Fetal Alcohol Exposure Fetal Alcohol Spectrum Disorder Fetal Development Fetal Growth Fetal Ultrasonography Fetus Forensic Medicine Functional disorder Genetic Goals Growth Hearing Heavy Drinking Human Image Infant Infant Development Investigation Knowledge Life Link Maternal Age Measures Mediating Medical Mental Depression Mission National Institute of Child Health and Human Development National Institute on Alcohol Abuse and Alcoholism Neurologic Neurotransmitters Outcome Participant Pathologic Pathology Pattern Performance Perfusion Perinatal Phase Physiological Physiology Placenta Population Pregnancy Principal Investigator Protocols documentation Public Health Reporting Request for Applications Research Research Personnel Risk Role Scientist Site South Africa Stress Structure Sudden infant death syndrome Synapses Testing Time U-Series Cooperative Agreements Ultrasonography Variant Woman adverse outcome aging nutrition base clinical research site critical period drinking fetal fetal tobacco exposure follow-up high risk in vivo indexing interest maternal cigarette smoking mother nutrition neurobehavioral northern plains postnatal prenatal prevent programs resilience response stillbirth tobacco exposure

项目摘要

DESCRIPTION (provided by applicant): This application is in response to a Request for Application (RFA-HD-10-018) to conduct community-linked studies to investigate the role of prenatal alcohol exposure in the risk for SIDS, stillbirth and FASD, and to determine how these different outcomes are inter-related, The proposed research will be conducted by the investigators the Prenatal Alcohol, SIDS and Stillbirth (PASS) Research Network in a cooperative agreement with NICHD and NIAAA. This research involves the collaboration of: 1) two comprehensive clinical sites serving populations that are high risk for prenatal alcohol exposure, SIDS, and stillbirth, i.e. the American Indians in the Northern Plains and the Cape Coloured in Cape Town, South Africa; 2) a central Developmental Biology and Pathology Centre (DBPC); 3) a central Data Coordinating and Analysis Center (DCAC); 4) a central Physiology Assessment Center (PAC); and 5) program scientists and officers at the NICHD and NIAAA. The mission of our site is to accomplish the 9 Specific Aims of the Safe Passage Study through the recruitment and enrollment of 7,000 women and the performance of all of the hypothesis-driven study protocols involving the maternal/fetal dyads. The SCCS is overseeing the performance and analysis of Specific Aim 3. This aim is to determine the role of prenatal alcohol exposure, as potentially modified by other environmental, genetic, and placental factors, upon the facial features, somatic growth, and neurological/brain development in the fetus and infant utilizing fetal ultrasonography and infant facial imaging and standardized feature assessment. We will test the hypotheses that: 1) prenatal alcohol exposure adversely impacts facial, somatic, and/or brain growth in the human fetus as early as 20-24 gestational weeks, i.e., the earliest time-point examined by us; 2) prenatal alcohol exposure is associated with facial dysmorphology that is identified by imaging of the face as early as 20-24 weeks and remains present at 1 postnatal month and 12 postnatal months; and 3) this alcohol toxicity is modified by other environmental and placental factors, such as maternal nutrition, maternal smoking, and placental perfusion failure.

描述（由申请人提供）：此申请是响应申请请求（RFA-HD-10-018）进行社区链接的研究，以调查产前酒精暴露在SIDS，Stillth和FASD风险中的作用，并确定这些不同的结果是如何相关的，该研究将如何通过调查人员进行研究。与NICHD和NIAAA的合作协议。这项研究涉及以下合作：1）两个全面的临床场所，为人群提供高风险的人口，小岛屿发展中国家和死产，即北部平原的美洲印第安人，以及南非开普敦的开普山。 2）中央发育生物学和病理中心（DBPC）； 3）中央数据协调和分析中心（DCAC）； 4）中央生理评估中心（PAC）； 5）NICHD和NIAAA的计划科学家和官员。我们站点的任务是通过招募和入学7,000名妇女的招募和招生以及所有涉及母体/胎儿二元组的所有假设驱动的研究方案来实现安全通道研究的9个特定目标。 SCC正在监督特定目的的性能和分析3。此目的是确定产前酒精暴露的作用，这可能会通过其他环境，遗传和胎盘因素，对面部特征，躯体生长以及胎儿和婴儿使用胎儿超声和婴儿面部造影和标准特征评估和婴儿的胎儿和婴儿中的神经/脑发育的影响。我们将测试以下假设：1）早在20-24胎周，即我们最早检查的时间点，对人胎儿的面部，体细胞和/或脑生长产生了不利影响； 2）产前酒精暴露与面部畸形学有关，该面部畸形与最早在20-24周的面部成像相关，并在产后1个月份和12个月后数月存在； 3）这种酒精毒性通过其他环境和胎盘因素（例如母体营养，孕产妇吸烟和胎盘灌注衰竭）来改变。