Support for the Charleston Ceramide Conference

支持查尔斯顿神经酰胺会议

基本信息

批准号：
8423722
负责人：
YUSUF AWNI HANNUN
金额：
$ 0.5万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-02-01 至 2015-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8423722
关键词：
1,2-diacylglycerol Address Advanced Development Aging Area Atherosclerosis Australia Biochemical Bioinformatics Biological Biology Canada Cancer Biology Cell physiology Cellular biology Ceramides Cerebrosides China Collaborations Computer Retrieval of Information on Scientific Projects Database Development Diglycerides Discipline Disease Distal Enzymes Explosion Faculty Feedback Fostering France Functional disorder Funding Germany Goals Health Human Immune System Diseases Individual Industry Inflammation Inflammatory Information Dissemination Institutes International Investigation Ireland Israel Italy Japan Korea Lead Lebanon Lipids Malignant Neoplasms Mass Spectrum Analysis Metabolic Metabolism Molecular Neoplasm Metastasis Nerve Degeneration Netherlands New Zealand Participant Pathogenesis Pathway interactions Pharmacologic Substance Pharmacology Postdoctoral Fellow Process Proteins Publications Regulation Relative (related person)Research Research Peer Review Research Personnel Role Scientist Seasons Signal Pathway Signal Transduction Spain Sphingolipids Sphingomyelinase Sphingosine Stenosis Techniques Therapeutic Therapeutic Agents Thrombosis Translational Research Travel Trees United States National Institutes of Health Ursidae Family Vascular Diseases Work analog base empowerment experience field study graduate student immunoregulation inhibitor/antagonist inorganic phosphate insight lipid metabolism mathematical model meetings nano next generation novel novel strategies programs skeletal disorder skin disorder sphingosine 1-phosphate symposium tumor progression

项目摘要

ABSTRACT This application seeks partial funding for an upcoming international conference, the fifth Charleston Ceramide Conference (CCC5) to be held March 11-14, 2009 at the Double Tree, Charleston, SC with expected 200 attendees (and approximately the same date in 2011 and 2013). The theme of the conference builds on two decades of investigation that have resulted in an explosion in research centered on bioactive sphingolipids; especially ceramide, sphingosine, sphingosine phosphate (S1P), ceramide phosphate (C1P), and other related lipids (more than 15000 pub med citations to these lipids). Current investigation is beginning to yield significant insight into the roles of bioactive sphingolipids in pathophysiology, including cancer biology, atherosclerosis, inflammation, neurodegeneration, fungal pathogenesis, skin disorders, and skeletal disorders. As a consequence, exciting possibilities for therapeutic applications are emerging based on\ analogs of bioactive sphingolipids and pharmacologic inhibitors. The purpose of the conference is 1) to bring together a wide variety of investigators who either investigate bioactive sphingolipids and/or have come to the realization of the importance of bioactive lipids in their own distinct fields of study; and 2) enable investigators in these areas to overcome the many difficulties usually encountered in studying lipids, their cell biology, their enzymes, and their function. CCC5 aims at bringing together world leaders in these areas of research into a common forum that enhances the exchange and development of ideas. The CCC has pioneered a novel format whereby most presentations are by junior faculty and by post doctoral fellows and graduate students with short presentations (15 min) followed by prolonged discussion (15 min). Senior investigators present keynote addresses, overviews, and oversee the dynamic discussions. Sessions will highlight novel approaches (e.g. sphinoglipidomics, mathematical modeling), cutting edge research, and translational science. The funds requested will be used exclusively to support the conference and travel expenses of junior investigators who will be attending the conference and presenting their work as invited presentations. The requested funds will be invaluable to the support of this conference.

抽象的本申请为即将召开的国际会议寻求部分资助，即第五届查尔斯顿神经酰胺会议 (CCC5)，该会议将于 2009 年 3 月 11 日至 14 日在南卡罗来纳州查尔斯顿 Double Tree 举行，预计将有 200 名与会者（与 2011 年和 2013 年的日期大致相同））。会议的主题建立在二十年的调查基础上，这些调查导致了以生物活性鞘脂为中心的研究的爆炸式增长；特别是神经酰胺、鞘氨醇、磷酸鞘氨醇 (S1P)、磷酸神经酰胺 (C1P) 和其他相关脂质（对这些脂质的 pubmed 引用超过 15000 次）。目前的研究已开始深入了解生物活性鞘脂在病理生理学中的作用，包括癌症生物学、动脉粥样硬化、炎症、神经变性、真菌发病机制、皮肤疾病和骨骼疾病。因此，基于生物活性鞘脂和药理抑制剂类似物的治疗应用的令人兴奋的可能性正在出现。会议的目的是 1) 汇集各种研究人员，他们要么研究生物活性鞘脂，要么已经认识到生物活性脂质在各自不同研究领域的重要性； 2）使这些领域的研究人员能够克服在研究脂质、其细胞生物学、酶及其功能时通常遇到的许多困难。 CCC5 旨在将这些研究领域的世界领导人聚集到一个共同的论坛上，以加强思想的交流和发展。 CCC 首创了一种新颖的形式，其中大多数演讲均由初级教师、博士后研究员和研究生进行，先进行简短的演讲（15 分钟），然后进行长时间的讨论（15 分钟）。高级研究人员发表主题演讲、概述并监督动态讨论。会议将重点介绍新颖的方法（例如鞘脂组学、数学建模）、前沿研究和转化科学。所申请的资金将专门用于支持参加会议并以特邀报告形式介绍其工作的初级研究人员的会议费用和差旅费。所请求的资金对于支持本次会议将是无价的。