Mitochondrial Biogenesis and Dynamics in Health, Disease and Aging

健康、疾病和衰老中的线粒体生物发生和动力学

• 批准号: 8528297
• 负责人: Giovanni Manfredi
• 金额: $ 0.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-11 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528297
• 关键词: Aging; Aging-Related Process; Alzheimer' s Disease; Area; Basic Science; Biogenesis; Biology; Cardiomyopathies; Cell Differentiation process; Cellular biology; Collaborations; Communication; Communities; Complex; Defect; Diabetes Mellitus; Disease; Friedreich Ataxia; Functional disorder; Glean; Goals; Health; Heart Diseases; Hereditary Spastic Paraplegia; Human; Immune response; Incidence; Inflammatory Response; Inherited; Leber' s Hereditary Optic Neuropathy; Leigh Disease; Link; Liver diseases; Longevity; Malignant Neoplasms; Medicine; Metabolic; Metabolic Diseases; Metabolism; Minority; Mitochondria; Mitochondrial Diseases; Montana; Morphology; Nerve Degeneration; Neurodegenerative Disorders; North America; Oral; Organelles; Outcome; Oxygen; Parkinson Disease; Pathology; Pathway interactions; Patients; Physiological Processes; Postdoctoral Fellow; Process; Production; Protein Import; Public Health; Regulation; Research; Research Personnel; Respiratory Chain; Role; Science; Scientist; Seminal; Signal Transduction; Site; Students; Time; Translational Research; Universities; Woman; Work; age related; cell growth; forging; frontier; graduate student; human disease; insight; interest; medical schools; meetings; mitochondrial dysfunction; novel; posters; public health relevance; respiratory; symposium

DESCRIPTION (provided by applicant): Mitochondria are essential cellular organelles, long noted for their central function in ATP production, as well as many other anabolic and catabolic pathways. Exciting new breakthroughs in our understanding of basic biology and function of mitochondria have taken place in recent years. New research has identified mitochondria as key players in many aspects of cell biology and disease, well beyond their central role in metabolism, including control of cell growth and differentiation, oxygen sensing and ROS signaling, and as hubs of the innate immune and inflammatory responses. These advances have led to realization that the contribution of mitochondria to human disease and aging is multifaceted and more far-reaching than previously anticipated. Therefore, the importance of the 2013 FASEB conference "Mitochondrial Biogenesis and Dynamics in Health, Disease and Aging", for which this proposal seeks support, is clear. There is a growing need to create interactions between investigators that understand and study the basic biology of the organelle with those engaged at these new frontiers of mitochondria, with the goal of melding these activities into a better understanding of how mitochondrial dysfunction contributes to human disease and aging. This area is undoubtedly one of the most exciting research topics in contemporary biology and medicine. The major topics that will be covered in this meeting are: 1) Basic Mitochondrial Biology, 2) Mitochondrial Diseases; 3) Mitochondria in Aging and Longevity; 4) New Frontiers in Mitochondrial Biology and Medicine. The meeting will bring together scientists with a broad range of expertise, ranging from established investigators to graduate students, to present and discuss the most recent advances in the biology of mitochondria and its links to disease and aging. The conference will facilitate discussion of basic and biomedical science as well as stimulate translational research opportunities. The goals will be: 1) to organize and support a conference in the field of mitochondrial biology and dysfunction. The conference will be held June 16-21, 2013, at the FASEB conference site in Big Sky, Montana; 2) to promote the exchange of scientific ideas among basic and translational scientists interested in diverse aspects of mitochondrial biology and mitochondrial dysfunction in human disease and in aging, with a focus on stimulate collaborative approaches and cross-field stimulation; 3) to encourage and promote participation by junior investigators, women and minorities, with the goal of integrating them in this important and rapidly growing field.

描述（由申请人提供）：线粒体是必不可少的细胞细胞器，长期以来因其在ATP产生中的中心功能以及许多其他合成代谢和分解代谢途径而闻名。近年来，我们对线粒体的基本生物学和功能的理解令人兴奋的新突破。新的研究已将线粒体确定为细胞生物学和疾病许多方面的关键参与者，远远超出了它们在代谢中的核心作用，包括控制细胞生长和分化，氧气传感和ROS信号，以及先天免疫和炎症反应的枢纽。这些进步导致人们意识到线粒体对人类疾病和衰老的贡献是多方面的，并且比以前预期的更深远。因此，明显的是，该提案寻求支持的2013年Faseb会议“线粒体生物发生和动态”的重要性很明显。越来越需要在研究和研究细胞器的基本生物学之间建立相互作用的人与参与这些新的线粒体前沿的生物学的基本生物学，其目的是更好地了解线粒体功能障碍如何有助于人类疾病和衰老。该领域无疑是当代生物学和医学中最令人兴奋的研究主题之一。在这次会议上将涵盖的主要主题是：1）基本的线粒体生物学，2）线粒体疾病； 3）线粒体在衰老和寿命中； 4）线粒体生物学和医学的新边界。会议将以广泛的专业知识汇集科学家，从成熟的研究人员到研究生，介绍和讨论线粒体生物学及其与疾病和衰老的联系的最新进展。会议将促进对基础和生物医学科学的讨论，并刺激转化研究机会。目标将是：1）在线粒体生物学和功能障碍领域组织和支持会议。会议将于2013年6月16日至21日在蒙大拿州大天空的Faseb会议地点举行； 2）在对人类疾病和衰老中线粒体生物学和线粒体功能障碍感兴趣的基础和翻译科学家之间促进科学思想的交流，重点是刺激协作方法和跨场刺激； 3）鼓励和促进初级调查人员，妇女和少数民族的参与，目的是将其整合到这个重要而快速增长的领域。