Molecular Imaging High Throughtput Screening

分子成像高通量筛选

• 批准号: 8195501
• 负责人: David Piwnica-Worms
• 金额: $ 6.35万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8195501
• 关键词: Cancer Center; Cellular biology; Comprehensive Cancer Center; Developmental Biology; Fees; Funding; Gifts; Grant; Institutes; Medical; Molecular Bank; Process; Radiology Specialty; Resource Development; Resources; Robotics; Screening procedure; TNFRSF5 gene; Time; United States National Institutes of Health; Universities; Washington; high throughput screening; in vivo Cellular and Molecular Imaging Centers; medical schools; molecular imaging; operation; programs; ranpirnase; response

In response to the NIH Roadmap to Molecular Libraries and Imaging, we conceived the process and now have fully established a P50 ICMIC High Throughput Screening Robotics Core. Core initiation represented a multi-departmental effort with fiscal support for establishing the Core coming from PSO funds in combination with the Department of Radiology, Department of Developmental Biology, and the Howard Hughes Medical Institute. The Dean of Washington University School of Medicine as well as the Director of the Washington University Siteman Cancer Center joined our effort with the commitment of additional funds for further development of the resource. Overall, nearly $2M was invested in the establishment of this resource, which has been in operation since late 2006. Since that time, the HTS Core has operated as a matrix core, receiving funds from the PSO ICMIC grant, the Siteman Cancer Center (through a gift of Emerson/Busch as well as funds as a Developing Core of the P30 NCI Comprehensive Cancer Center grant), and recharge fees to users. This Core serves as an outstanding on-going example of how our PSO program has leveraged university resources and continues to stimulate interdisciplinary molecular imaging activity throughout the WU campus. Functionally and symbolically, Drs. Helen Piwnica-Worms (Cell Biology), Rafi Kopan (Developmental Biology), and David Piwnica-Worms (Radiology) serve as Core Co-Directors with shared administration and scientific oversight of Core activities. The PSO funds effort for David Piwnica-Worms, while the Siteman funds effort for Helen Piwnica-Worms and Rafi Kopan.

为了响应 NIH 分子库和成像路线图，我们构思了该流程并 目前已全面建立P50 ICMIC高通量筛选机器人核心。代表核心启动 多部门共同努力，并结合 PSO 资金为建立核心提供财政支持 与放射科、发育生物学系和霍华德休斯医学中心合作 研究所。华盛顿大学医学院院长兼华盛顿大学医学院院长 大学斯特曼癌症中心加入了我们的努力，并承诺提供额外资金以进一步开展研究 资源的开发。总体而言，该资源的建立投资了近 200 万美元， 自 2006 年底以来一直在运行。从那时起，HTS Core 就作为矩阵核心运行，接收 来自 PSO ICMIC 赠款、Siteman 癌症中心的资金（通过艾默生/布希的捐赠以及资金 作为 P30 NCI 综合癌症中心赠款的开发核心），并向用户充值。这 Core 是我们的 PSO 计划如何利用大学的一个杰出的持续示例 资源并继续刺激整个西大学的跨学科分子成像活动 校园。从功能上和象征意义上来说，博士。 Helen Piwnica-Worms（细胞生物学）、Rafi Kopan （发育生物学）和 David Piwnica-Worms（放射学）担任核心联合主任 核心活动的共同管理和科学监督。 PSO 为 David 提供资金 Piwnica-Worms，而 Siteman 则资助 Helen Piwnica-Worms 和 Rafi Kopan 的工作。