National Cell Respository for Alzheimer's Disease (NCRAD) (U24)

国家阿尔茨海默病细胞存储库 (NCRAD) (U24)

• 批准号: 8336962
• 负责人: TATIANA M. FOROUD
• 金额: $ 95.99万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8336962
• 关键词: Advisory Committees; Affect; Age; Aliquot; Alzheimer' s Disease; Alzheimer' s disease risk; American; Biological; Biological Markers; Blood specimen; Brain; Cell Line; Cells; Clinical Data; Communities; Core Facility; DNA; DNA Library; DNA Sequence; Data; Data Coordinating Center; Dementia; Disease; Disease susceptibility; Enrollment; Ensure; Etiology; Family; Fostering; Frequencies; Funding; Future; Genetic; Genome; Genomics; Genotype; Goals; Human Resources; Indiana; Individual; Instruction; Lifting; Manuscripts; Measures; Meta-Analysis; Mission; National Institute on Aging; Onset of illness; Paper; Physicians; Plasma; Play; Positioning Attribute; Principal Investigator; Procedures; Protocols documentation; Publications; Qualifying; RNA; Recruitment Activity; Research; Research Personnel; Resources; Risk; Sampling; Secure; Solutions; Source; Specimen; Testing; Time; U-Series Cooperative Agreements; United States National Institutes of Health; Variant; Work; base; brain tissue; cell bank; data sharing; distributed data; exome; genome-wide; improved; meetings; new technology; prevent; programs; repository; research study; sample collection; success; tool

Program Director/Principal Investigator (Last, First, Middle): ForOUd, Tatiana, M. PROJECT SUMIVIARY (See instructions): The National Cell Repository for Alzheimer's Disease (NCRAD) plays a key role in the National Institute on Aging's (NIA) efforts to identify those at risk for Alzheimer disease (AD) and develop improved treatments to delay or prevent disease onset NCRAD was established as a cooperative agreement with the NIA to serve as the primary source of sample sharing for all NIA-funded dementia studies. Under the advisement of NIA and the Cell Bank Advisory Committee, it is the mission of NCRAD to remove critical bamers hindering reseach progress to understand the etiology of dementia. To achieve this goal, NCRAD has two primary functions: sample banking and sample distribution. NCRAD serves as a central repository banking samples from ongoing NIA funded studies using unifomn protocols with extensive quality measures. The type of samples being banked has expanded to include DNA, cell lines, plasma, serum, brain tissue and RNA. NCRAD works closely with the National Alzheimer Coordinating Center (NACC), another NIA core facility that serves as the data coordinating center for all the Alzheimer Disease Centers (ADCs). Together, NCRAD and NACC serve as key resources within the Alzheimer Disease Genetics Consortium (ADGC), coordinating the collection of samples from the 29 ADCs. NCRAD also widely distributes samples both to investigators for their own analyses as well as to central cores, where APOE genotyping, genomewide SNP arrays, and now whole genome and whole exome sequencing studies are performed. We propose to expand our successful efforts with the following specific aims; 1. To provide a state-of-the-art central biospecimen repository for all NIA-funded dementia studies that includes detailed standard operating procedures for the secure banking of DNA, cell lines, plasma, serum, RNA, and brain tissue. 2. To facilitate and foster sample sharing by distributing data and biospedmens to all qualified investigators for use in their research studies. RELEVANCE (See instructions): There are a number of barriers that hamper the ability of researchers to perform successful studies of Alzheimer disease and related dementias. These include the ability to share samples, access to large numbers of high quality samples and effective sharing of research results. NCRAD under the advisement of NIA and CBAC will lift these ban-iers and faciliate sample and data sharing among dementia researchers.

计划主任/首席研究员（最后，第一，中间）：Foroud，Tatiana，M。 项目Sumiviary（请参阅说明）： 阿尔茨海默氏病（NCRAD）国家细胞库在国家研究所起着关键作用 关于衰老（NIA）识别有阿尔茨海默氏病风险的人（AD）的努力并开发改进的治疗方法 延迟或预防疾病发作是与NIA的合作协议建立的 作为所有NIA资助的痴呆症研究的样本共享的主要来源。根据 NIA和Cell Bank咨询委员会，NCRAD的任务是消除严重的BAMERS阻碍 研究进步以了解痴呆症的病因。为了实现这一目标，Ncrad有两个主要 功能：样本银行和样本分布。 NCRAD是使用Unifomn的NIA资助研究中的中央存储库银行样品 具有广泛质量措施的协议。所在的样本类型已扩展到包括DNA， 细胞系，血浆，血清，脑组织和RNA。 Ncrad与国家阿尔茨海默氏症紧密合作 协调中心（NACC），另一个NIA核心设施，可作为所有数据协调中心 阿尔茨海默氏病中心（ADC）。 NCRAD和NACC一起充当关键资源 阿尔茨海默氏病遗传学联盟（ADGC），协调29个ADC的样品收集。 Ncrad还广泛地将样品分配给研究人员进行分析以及中央 核心，APOE基因分型，全基因组SNP阵列以及现在的整个基因组和整个外显子组 进行测序研究。我们建议通过以下特定的特定努力扩大我们的成功努力 目标； 1。为所有NIA资助的痴呆症研究提供最新的中央生物循环库 包括用于DNA，细胞系，血浆，血清的详细标准操作程序 RNA和脑组织。 2。通过向所有合格的调查人员分配数据和生物群来促进和培养样品共享 用于他们的研究。 相关性（请参阅说明）： 有许多障碍阻碍了研究人员进行成功研究的能力 阿尔茨海默氏病和相关痴呆症。其中包括共享样品的能力，访问大型 高质量样本的数量和研究结果的有效共享。 Ncrad在 NIA和CBAC将提升这些Ban-iers，并促进痴呆症研究人员之间的样本和数据共享。