Cancer Biology

癌症生物学

基本信息

批准号：
8557658
负责人：
ROY A. JENSEN
金额：
$ 2.37万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-11 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8557658
关键词：
Accounting Affect Antineoplastic Agents Apoptosis Area BRAF gene BRMS1 gene Basic Cancer Research Basic Science Behavior Biochemical Biochemistry Biological Biological Markers Biology Biometry Breast Cancer Biology Cancer Center Cancer Center Support Grant Cancer Patient Caring Cell Communication Cell Proliferation Cells Cellular biology Cessation of life Characteristics Chromatin Clinical Collaborations Commit Complex Data Development Discipline Disease Drug Delivery Systems Fostering Funding Gene Expression Genetic Goals Grant Growth Growth and Development function Head and Neck Squamous Cell Carcinoma Hematopoietic Neoplasms Hematopoietic System Histone Deacetylase Individual Institutes Institution Instruction Kansas Kidney Kidney Neoplasms Lead Leadership Liver Liver diseases Malignant - descriptor Malignant Neoplasms Medicine Metabolic syndrome Metabolism Methods Modeling Molecular Molecular Biology Neoplasm Metastasis Neoplasms Normal Cell Oncogenic Paper Participant Pathway interactions Peer Review Polycystic Kidney Diseases Positioning Attribute Process Publications Publishing Quality of life Recording of previous events Recruitment Activity Regulation Research Research Personnel Resource Sharing Science Series Signal Pathway Signal Transduction Staging Therapeutic Time Transcriptional Regulation Translating Translational Research Translations Tumor Stem Cells Tumor Suppressor Genes United States National Institutes of Health Universities Work anticancer research base bench to bedside cancer cell cancer prevention cancer stem cell cancer therapy cancer type cell behavior cell growth cellular targeting chromatin modification clinical practice experience gastrointestinal in vitro Model in vivo informatics shared resource inhibitor/antagonist interest melanoma member neoplastic cell novel osteosarcoma pre-clinical prognostic programs response stem cell biology success symposium transdifferentiation tumor tumor growth tumor progression

项目摘要

PROJECT SUMMARY (See instructions): The scientific goal of the Cancer Biology program (CB) is to understand the molecular mechanisms that define normal and neoplastic cell growth in order to identify and characterize molecules, pathways and processes that are involved in tumor development, growth and progression. CB is a new program that represents the basic science initiatives of KUCC and is unified by member utilization of molecular, biochemical, and cell-based approaches that study the aberrant behavior of cancer cells. The overarching goal of CB is to catalyze collaborations that promote basic discoveries that can be translated from bench-to-bedside. The Specific Aims of CB are 1) to promote collaboration that enhances discovery of the cellular, molecular and biochemical mechanisms that underlie tumor development, progression and malignant behavior; and 2) to leverage basic science discoveries to inspire pre-clinical and clinical development of novel cancer therapies. CB has 32 full members and 11 associate members, representing all KUCC institutions. Even at this early stage of KUCC growth, CB has garnered $17 million in cancer-related, peer-reviewed funding, of which $1.9 million was from NCI and $15.1 was from other peer-review sponsors. From 2006-2010, members published 250 cancer-relevant, peer-reviewed papers which were cited 2904 times (average 10.8 citations/publication) of which 7% were the result of inter-programmatic interactions and 15% from intra-programmatic interactions. In addition, CB program members accounted for 10.2% of the usage of the Biospecimen Shared Resource, 7.09% of the usage of the Biostatistics & Informatics Shared Resource, and 8.57% of the usage of the Lead Development & Optimization Shared Resource in 2010. CB is jointly led by Yvonne Wan and Linheng Li, who bring complementary scientific expertise, growing leadership experience, and diverse institutional representation. They will work closely with Danny R. Welch, Associate Director for Basic Science. CB has taken advantage of historical strengths at KUMC, KU-Lawrence and the Stowers Institute in liver, Gl, kidney and hematopoietic tumors. Recent recruitments have expanded those initiatives to include breast, HNSCC, and osteosarcoma research. In addition to a disease-based thematic organization, CB members have expertise that can be organized into four discipline-based themes - Chromatin Organization and Transcriptional Regulation, Signaling Pathways and Development, Cancer Cell Biology and Stem Cell Biology; and Cell Proliferation, Differentiation and Death,

项目摘要（参见说明）：癌症生物学计划 (CB) 的科学目标是了解定义正常和肿瘤细胞生长的分子机制，以便识别和表征参与肿瘤发生、生长的分子、途径和过程。和进展。 CB 是一个新计划，代表 KUCC 的基础科学举措，由成员利用分子、生物化学和基于细胞的方法来研究癌细胞的异常行为。 CB 的首要目标是促进合作，促进可从实验室转化为临床的基本发现。 CB 的具体目标是 1) 促进合作，增强对肿瘤发生、进展和恶性行为背后的细胞、分子和生化机制的发现； 2）利用基础科学发现来激发新型癌症疗法的临床前和临床开发。 CB有32名正式会员和11名准会员，代表所有KUCC机构。即使在 KUCC 发展的早期阶段，CB 也已获得 1700 万美元的癌症相关同行评审资金，其中 190 万美元来自 NCI，15.1 美元来自其他同行评审赞助商。从 2006 年到 2010 年，成员发表了 250 篇与癌症相关的同行评审论文，被引用 2904 次（平均 10.8 次引用/出版物），其中 7% 是项目间交互的结果，15% 是项目内交互的结果。此外，2010 年，CB 计划成员占生物样本共享资源使用量的 10.2%、生物统计和信息学共享资源使用量的 7.09%、先导化合物开发和优化共享资源使用量的 8.57%。由 Yvonne Wan 和 Linheng Li 共同领导，他们带来了互补的科学专业知识、不断增长的领导经验和多元化的机构代表性。他们将与基础科学副主任 Danny R. Welch 密切合作。 CB 充分利用了 KUMC、KU-Lawrence 和 Stowers 研究所在肝脏、胃肠道、肾脏和造血肿瘤方面的历史优势。最近的招募扩大了这些举措，包括乳腺、头颈部鳞癌和骨肉瘤研究。除了基于疾病的主题组织外，CB 成员还拥有可分为四个基于学科的主题的专业知识：染色质组织和转录调控、信号传导途径和发育、癌细胞生物学和干细胞生物学；和细胞增殖、分化和死亡，