CFM: Longitudinal Outcomes in Children pre-Kindergarten (CLOCK)

CFM：学前班儿童的纵向结果 (CLOCK)

• 批准号: 8705617
• 负责人: Carrie Lyn Heike
• 金额: $ 18.89万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8705617
• 关键词: 3 year old; Address; Affect; Age; Anatomy; Area; Behavior assessment; Behavioral; Child; Child Care; Cohort Studies; Collaborations; Complex; Congenital neurologic anomalies; Cranial nerve diseases; Data; Deformity; Development; Diagnosis; Disease; Ear; Early Intervention; Emotions; Enrollment; Etiology; Evaluation; External Ear; Face; Facial asymmetry; Facial nerve structure; Foundations; Future; Goals; Healthcare; Hearing; Individual; Infant; Infant Development; Intervention; Investigation; Labyrinth; Lead; Link; Longitudinal Studies; Mandible; Maps; Maxilla; Measures; Mediator of activation protein; Methods; Movement; Neuraxis; Outcome; Outcome Assessment; Participant; Pathway interactions; Patients; Performance; Production; Protocols documentation; Randomized Clinical Trials; Randomized Controlled Trials; Research; Research Design; Risk; School-Age Population; Schools; Series; Severities; Socialization; Speech; Structure; Testing; Time; Toddler; Tongue; Unilateral Hearing Loss; base; craniofacial; craniofacial microsomia; hearing impairment; improved; kindergarten; malformation; meetings; middle ear; neurobehavioral; neurodevelopment; neuropsychological; orofacial; social; soft tissue; standard measure; standard of care

DESCRIPTION (provided by applicant): Craniofacial microsomia (CFM) is a complex, congenital condition associated with underdevelopment of the facial structures. This condition is frequently associated with malformations of the outer, inner and middle ear, mandible, soft tissue, and facial nerve, resulting in varying degrees of facial asymmetry. As a result, children with CFM have elevated risk of hearing loss, impaired speech production, neurodevelopmental delays, poor academic and social outcomes, and behavioral maladjustment. Our prior studies in school-age children with CFM demonstrate that children with CFM do not perform as well on neuropsychological and social outcome assessments as children without craniofacial conditions. However, no studies have been performed in infants and toddlers and nor have the specific mechanisms contributing to these outcomes been investigated. The long term goals of our research consortium are to improve neurodevelopmental, social, and behavioral outcomes for children with CFM. The proposed research includes a longitudinal cohort study in children with and without CFM. The rationale underlying the research plan is that better understanding of the direct and indirect effects of CFM malformations on development will lead to the identification of more specific and effective early interventions. This proposal outlines a multi-center, longitudinal cohort study of 125 infants with CFM and 100 infants without craniofacial anomalies. Participants will undergo a series of evaluations between ages 0-3 years of age to comprehensively evaluate the developmental status of infants and toddlers with CFM. This research design will also explore specific pathways by which CFM may lead to certain outcomes. Specifically, the proposal explores (1) the longitudinal relations between facial asymmetry and emotion-related facial movements and poor socialization; and (2) associations among ear malformations, hearing and speech deficits and neurobehavioral outcomes. Results of this research will ultimately lead to future investigations that assess new interventions and corresponding changes in current standards of care for children with CFM.

描述（由申请人提供）：颅面微粒体（CFM）是一种复杂的先天性状况，与面部结构不发达有关。这种情况通常与外耳，下颌骨，软组织和面神经的畸形有关，导致面部不对称程度不同。结果，CFM患者的听力损失风险较高，言语产生受损，神经发育延迟，学术和社会成果差以及行为不善。我们先前在具有CFM的学龄儿童的研究表明，患有CFM的儿童在神经心理学和社会结局评估上的表现不佳，而不是没有颅面状况的儿童。但是，未对婴儿和幼儿进行研究，也没有研究为这些结果的具体机制。我们研究联盟的长期目标是改善CFM儿童的神经发育，社会和行为结果。拟议的研究包括对患有和没有CFM的儿童的纵向队列研究。研究计划的基本原理是，更好地了解CFM畸形对开发的直接和间接影响将导致鉴定更具体和有效的早期干预措施。该提案概述了125名CFM和100名没有颅面异常的婴儿的多中心，纵向队列研究。参与者将接受一系列0-3岁之间的评估，以全面评估婴儿和CFM幼儿的发育状况。该研究设计还将探索CFM可能导致某些结果的特定途径。具体而言，该提案探讨了（1）面部不对称与与情绪有关的面部运动与社会化差之间的纵向关系； （2）耳朵畸形，听力和言语缺陷和神经行为结果之间的关联。这项研究的结果最终将导致未来的调查，以评估CFM儿童当前护理标准的新干预措施和相应变化。