4D Statistical Atlas from Multimodal Tongue MR Images

多模态舌 MR 图像的 4D 统计图谱

• 批准号: 8510213
• 负责人: Jonghye Woo
• 金额: $ 9.72万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8510213
• 关键词: Affect; Anatomy; Anser species; Apical; Atlases; Award; Behavior; Breathing; Calculi; Cine Magnetic Resonance Imaging; Classification; Computer software; Data; Data Set; Deglutition; Development; Diagnosis; Diagnostic; Disease; Eating; Foundations; Future; Geese; Generations; Glossectomy; Goals; Health; Human; Image; Image Analysis; Imagery; Individual; Jaw; Journals; Knowledge; Lateral; Location; Magnetic Resonance Imaging; Maps; Mastication; Measurement; Measures; Mechanics; Medical Research; Mentors; Mentorship; Modality; Motion; Muscle; Muscle strain; Operative Surgical Procedures; Patients; Pattern; Phase; Play; Population; Positioning Attribute; Procedures; Process; Production; Publishing; Quality of life; Radiation; Research; Research Design; Research Personnel; Resolution; Role; Science; Shapes; Source Code; Speech; Speech Disorders; Speech Pathology; Structure; Surface; Surgeon; System; Target Populations; Techniques; Testing; Time; Tissues; Tongue; Torsion; Training; Variant; Work; base; bioimaging; cancer surgery; career; computerized tools; forest; image processing; image registration; imaging modality; improved; insight; malignant tongue neoplasm; motor control; movie; outcome forecast; preference; public health relevance; theories; tongue apex; tool

DESCRIPTION (provided by applicant): The tongue is the gateway to the body and is critical in eating, speaking, and breathing. Its function is compromised by disease and also by treatment, such as surgery or radiation for tongue cancer. A key to understanding the relationship between the structure and function of the tongue is to analyze motion changes in localized tongue regions and map them to anatomy. The use of three types of magnetic resonance (MR) images (i.e., high-resolution, cine, and tag) offers new and enhanced capabilities for exploring normal and diseased tongue behavior, advancing our knowledge on a wide variety of speech-related disorders. Quantitative measures derived from MR images, such as tissue compression, expansion, principle strain, and muscle mechanics play a crucial role to characterize normal and abnormal motion of the tongue. However, the critical hurdle currently faced in this field is a lack of tools for accurate, reproducible, and fully automated quantitative characterization of 4D (3D space with time) tongue motion in a normalized space in order to compare and contrast subjects despite their variable tongue sizes, shapes, and motion patterns. A powerful way to measure changes and compromises in tongue structure and function is via a 4D statistical atlas and associated image analysis techniques. Atlases integrate diverse imaging information for individuals and groups, by correlating images with quantitative measurements, and constructing diagnostic tools. The proposed study examines structural and functional changes in the tongues of post- glossectomy patients. In future, this atlas can be applied to any normal or disordered population. The K99 Mentored Phase allows me to transition to a career that studies tongue anatomy, speech science, and vocal tract-related disorders. In addition, I will execute Aim 1: to develop an MRI registration framework and an interactive visualization tool for tongue image analysis using multiple MRI methods. In the R00 Independent Phase, I will pursue Aim 2: to establish a 4D statistical atlas of the tongue that represents the relationship between tongue motion, mechanics, and speech, and Aim 3: to assess the effects of tongue cancer surgery on tongue tip, blade, and body interaction. A mentoring committee has been assembled to guide the research in the K99 phase and facilitate my training. Dr. Stone, who is an expert in speech science and imaging, will provide primary mentorship and guidance in the overall study design. Co- mentor, Dr. Prince, is a world expert in MR image analysis. He will guide me in image analysis. The opportunities provided by this award will not only allow me to pursue potentially ground-breaking research, but will also provide me with valuable mentorship and training for my career as an independent investigator.

描述（由申请人提供）：舌头是通往身体的门户，对于饮食，说话和呼吸至关重要。它的功能受到疾病和治疗的损害，例如手术或舌癌的辐射。理解舌头的结构和功能之间关系的关键是分析局部舌头区域的运动变化并将其映射到解剖结构。使用三种类型的磁共振（MR）图像（即高分辨率，CINE和TAG）提供了新的和增强的功能，可探索正常和患病的舌头行为，从而促进了我们对各种与言语相关疾病的知识。从MR图像中得出的定量测量，例如组织压缩，扩张，原理应变和肌肉力学，在表征舌头正常和异常运动方面起着至关重要的作用。但是，该领域目前面临的关键障碍是缺乏用于准确，可重复和完全自动化的定量的工具 尽管舌头大小，形状和运动模式可变，但在标准化空间中的4D（3D空间）舌头运动的表征以比较和对比度。衡量变化和妥协舌结构和功能的强大方法是通过4D统计地图集和相关的图像分析技术。通过将图像与定量测量和构建诊断工具相关联，通过将图像与个人和群体相结合的各种成像信息。拟议的研究检查了后骨切除术患者舌头的结构和功能变化。将来，该地图集可以应用于任何正常或无序的人口。 K99的指导阶段使我能够过渡到研究舌解剖学，言语科学和与人声有关的疾病的职业。此外，我会 执行AIM 1：开发MRI注册框架和使用多种MRI方法的舌头图像分析的交互式可视化工具。在R00独立阶段，我将追求目标2：建立一个舌头的4D统计地图集，代表舌头运动，力学和言语之间的关系，以及目标3：评估舌癌手术对舌头尖端，刀片和身体相互作用的影响。已经组建了一个指导委员会，以指导K99阶段的研究，并促进我的培训。斯通博士是语音科学和成像专家，将在整个研究设计中提供主要的指导和指导。合作者Prince博士是MR图像分析的世界专家。他将指导我进行图像分析。该奖项提供的机会不仅可以让我从事潜在的开创性研究，而且还将为我为我作为独立调查员的职业提供宝贵的指导和培训。