International Aldosterone Conference - Cardiovascular

国际醛固酮会议 - 心血管

• 批准号: 8130434
• 负责人: GORDON H WILLIAMS
• 金额: $ 1.5万
• 依托单位: INTERNATIONAL ALDOSTERONE CONFERENCE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8130434
• 关键词: Adrenal Cortex; Adrenergic Agonists; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biochemistry; Blood Vessels; Cardiac Myocytes; Cardiovascular Diseases; Cardiovascular system; Caveolins; Cells; Clinical Trials; Conflict (Psychology); Corticotropin; Data; Development; Diabetes Mellitus; Discipline; Disease; Endocrinologist; Endothelial Cells; Endothelin; Epithelial Cells; Experimental Models; Explosion; Floods; Fostering; Functional disorder; Genetic; Growth; Health; Heart Diseases; Homeostasis; Human; Hyperaldosteronism; Hypertension; Individual; International; Kidney; Lysine; Mediating; Metabolic syndrome; Mineralocorticoid Receptor; Modeling; Molecular; Molecular and Cellular Biology; Mononuclear; Natriuretic Peptides; Neurons; Obesity; Outcome; Pathway interactions; Pattern; Physiology; Potassium; Receptor Activation; Regulation; Research Personnel; Role; Science; Series; Sleep Apnea Syndromes; Smooth Muscle Myocytes; Stroke; System; Therapeutic Human Experimentation; Time; cardiovascular injury; cardiovascular risk factor; career; meetings; prevent; programs; rapid growth; receptor; skills; symposium; vascular inflammation

DESCRIPTION (provided by applicant): We are requesting support for a series of annual conferences from 2011 - 2015 to be called the International Aldosterone Conference-Cardiovascular. The objective of these conferences is to expand the understanding of the science - from cells to humans - underlying the role of aldosterone and mineralocorticoid receptor activation in increasing cardiovascular risk across a broad range of cardiovascular diseases, e.g., hypertension, diabetes mellitus, obesity, sleep apnea, metabolic syndrome, heart disease, stroke and renal dysfunction. This objective will be accomplished by using the approach and format of the International Aldosterone Conference. This approach has been successful in the past to accomplish a similar objective directed at the mechanism of activation of the mineralocorticoid receptor in epithelial cells, e.g., in the kidney. The format consists of an annual meeting for five years. Each annual meeting will consist of three half-day sessions. Each session begins with a state-of-the-art speaker who is an expert in a specific discipline related to aldosterone but who is not per se and expert in aldosterone. The attendees are experts and researchers in aldosterone/mineralocorticoid receptor physiology, pathophysiology, clinical trials, biochemistry, molecular and cellular biology and genetics. Young investigators in the field are encouraged to attend. The outcome from this series of conferences will be better understanding of the factors underlying the adverse cardiovascular effects produced by an activated aldosterone/mineralocorticoid receptor system. With this increased understanding will come better approaches to prevent and/or treat cardiovascular diseases.

描述（由申请人提供）：我们请求支持 2011 年至 2015 年召开的一系列年度会议，即国际醛固酮心血管会议。这些会议的目的是扩大对从细胞到人类的科学的理解，了解醛固酮和盐皮质激素受体激活在增加多种心血管疾病（例如高血压、糖尿病、肥胖、睡眠）中心血管风险中的作用。呼吸暂停、代谢综合征、心脏病、中风和肾功能不全。这一目标将通过使用国际醛固酮会议的方法和形式来实现。这种方法过去已经成功地实现了针对上皮细胞（例如肾脏）中盐皮质激素受体激活机制的类似目标。该形式包括五年一次的年会。每次年会将由三个半天的会议组成。每次会议都由一位最先进的演讲者开始，他是醛固酮相关特定学科的专家，但本身并不是醛固酮方面的专家。与会者是醛固酮/盐皮质激素受体生理学、病理生理学、临床试验、生物化学、分子和细胞生物学以及遗传学方面的专家和研究人员。我们鼓励该领域的年轻研究人员参加。这一系列会议的成果将是更好地了解激活的醛固酮/盐皮质激素受体系统产生的不良心血管影响的潜在因素。随着了解的加深，将会有更好的方法来预防和/或治疗心血管疾病。