Pacific Southwest RCE for Biodefense & Emerging Infectious Diseases Research

太平洋西南生物防御 RCE

• 批准号: 8435012
• 负责人: Alan G. Barbour
• 金额: $ 1.11万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-20 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8435012
• 关键词: Arenavirus; Basic Science; Bontoxilysin; Burkholderia; Categories; Coccidioidomycosis; Communicable Diseases; Core Facility; Dengue; Diagnosis; Diagnostic; Disease; Emergency Situation; Emerging Communicable Diseases; Equilibrium; Fostering; Goals; Human; Infection; Infectious Diseases Research; Institution; Latin America; Learning; Nipah Virus; Prevention; Public Health; Research; Research Personnel; Resources; Science; Therapeutic Agents; Training; Translational Research; Tularemia; United States; Vaccines; Viral; Zoonoses; biodefense; career; improved; multidisciplinary; novel therapeutics; operation; programs

Pacific-Southwest Regional Center of Excellence for Biodefense and Emerging Diseases ("the Center") is a research consortium comprising 34 projects clustered within seven programs. The Center also features five differentiated core facilities that serve the entire region. All four states (AZ, CA, HI, and NV) of Region IX are represented among the 27 educational, research, commercial, and governmental institutions of the Center. The overall goal of the Center is outstanding science, achieved with a multidisciplinary and collaborative approach and a portfolio that balances basic and translational research. The Center's major theme is infections of the western United States, the Pacific Rim, and Latin America of relevance for biodefense or as emerging diseases. The seven programs are: (1) dengue, (2) viral zoonoses, including arenaviruses and Nipah virus, (3) botulinum neurotoxin, (4) Category B Burkholderia species, (5) tularemia, (6) coccidioidomycosis, and (7) reservoir-targeted vaccines for prevention of human infections. Applications of the research include improved diagnostics, novel therapeutic agents, and vaccine platforms. Other key functions of the Center are: (a) responding, in cooperation with public health agencies, to infectious diseases emergencies with its collective expertise, resources, and facilities; (b) fostering the careers of talented young investigators and more established investigators newly-entering this research field; and (c) providing a region-wide training facility for investigators and staff to learn safe operations under biocontainment conditions.

Pacific-Southwest区域生物充血和新兴疾病卓越中心（“ The Center”）是一个研究联盟，其中包括34个项目，这些项目聚集在七个计划中。该中心还设有五个为整个地区提供服务的区分核心设施。 IX地区的所有四个州（AZ，CA，HI和NV）均在该中心的27个教育，研究，商业和政府机构中代表。该中心的总体目标是杰出的科学，它通过多学科和协作的方法以及平衡基本和转化研究的投资组合实现。该中心的主要主题是对美国西部，太平洋地区和拉丁美洲的感染，与生物化的相关性或作为新兴疾病的感染。这七个程序是：（1）登革热，（2）病毒人畜共患病，包括体育症病毒和尼帕病毒，（3）肉毒杆菌神经毒素，（4）B burkholderia物种，（5）Tularemia，（5）（5）（5）（6）coccidioycisosis，以及（7）储藏式疫苗的疫苗，人为疫苗。该研究的应用包括改进的诊断，新型治疗剂和疫苗平台。该中心的其他关键功能是：（a）与公共卫生机构合作，以其集体专业知识，资源和设施的紧急情况进行回应； （b）培养才华横溢的年轻调查员的职业和更知名的研究人员，新进入该研究领域； （c）为调查人员和工作人员提供一个范围内的培训设施，以在生物内部培养条件下学习安全的操作。