Mechanisms of Alcohol Pathology: A Collaborative Partnership Between NCCU & UNC

酒精病理学机制：国立政治大学之间的合作伙伴关系

• 批准号: 8307386
• 负责人: Gregory Jay Cole
• 金额: $ 93.34万
• 依托单位: NORTH CAROLINA CENTRAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8307386
• 关键词: Alcohol abuse; Alcoholism; Alcohols; Behavioral; Biotechnology; Education; Educational Curriculum; Faculty; Fellowship; Investigation; Mentors; Minority; Minority-Serving Institution; Molecular; Morbidity - disease rate; North Carolina; Pathology; Research; Research Institute; Series; Students; Tissues; U-Series Cooperative Agreements; Universities; alcohol exposure; alcohol pharmacology; alcohol research; cellular pathology; health disparity; medical schools; problem drinker; programs; success; university student

DESCRIPTION (provided by applicant): This is an application for a cooperative agreement (U54), "Mechanisms of Alcoholic Pathology" (MAP), between faculties of the Biomedical/Biotechnology Research Institute (BBRI) at North Carolina Central University (NCCU), a Minority-Serving Institution, and the Bowles Center for Alcohol Studies at The University of North Carolina (UNC) School of Medicine. This proposal represents a true collaborative effort between the NCCU and UNC faculty with both groups contributing significant effort and being essential to the success of this CMARCD Program. Within this proposal, an NCCU Administrative component and three Research Components will integrate with the UNC-ARC Administrative, Education, 5 Research Components, and Cores, as well as other activities at the Bowles Center for Alcohol Studies. The UNC-ARC investigates mechanisms of alcohol pathology across the spectrum of behavioral, tissue, and cellular pathologies that occur with alcohol exposure. This proposal will focus on cellular pathologies that easily integrate into the ongoing overall theme of the UNC-ARC. Thus, both the UNC-ARC research components and this U54 proposal are integrated around the central theme that alcohol-induced pathology involves molecular and cellular changes that occur with alcohol abuse and alcoholism. The objectives of this U54 partnership are: 1) To investigate molecular mechanisms of alcohol-induced cellular pathology. By conducting an integrated and focused investigation into the molecular mechanisms of alcohol pathology this proposal will make important contributions to understanding alcohol morbidity and will create an active and successful research program on alcohol pathology at NCCU; 2) To provide scholarly education on Alcohol Pathology. The educational efforts in this proposal will educate NCCU students on alcohol pharmacology and alcohol related pathologies and health disparities through a combined Annual Alcohol Research Day, new alcohol course curricula developed by NCCU faculty, an alcohol seminar series hosted by the BBRI, the UNC Bowles Center for Alcohol Studies seminar series, and NCCU fellowships to students on alcohol pathology and minorities. Ultimately, this proposal will conduct, promote, support, and mentor research into mechanisms of alcohol pathology, creating an acfive and successful alcohol research program within the NCCU-BBRI that synergizes with the UNC-ARC to advance education and discoveries.

描述（由申请人提供）：这是合作协议（U54）的申请，“酒精病理学机制”（地图），在北卡罗来纳州中央大学（NCCU）的生物医学/生物技术研究所（BBRI）之间，少数族裔服务学院，北卡罗莱纳大学的酒精研究中心（Uncer of North Carolina）（Unc）的酒精研究中心（NCCU）。该提案代表了NCCU与UNC教师之间的真正合作努力，这两个群体都付出了巨大的努力，并对该CMARCD计划的成功至关重要。在该提案中，NCCU的行政组成部分和三个研究组成部分将与UNC-ARC行政，教育，5个研究组件和核心以及鲍尔斯酒精研究中心的其他活动集成。 UNC-ARC研究了酒精暴露时发生的行为，组织和细胞病理学范围内酒精病理学的机制。该提案将集中在细胞病理上，这些病理很容易整合到UNC-ARC的持续总体主题中。因此，UNC-ARC研究组成部分和该U54提案都围绕着酒精诱导的病理学涉及酒精滥用和酒精中毒发生的分子和细胞变化的中心主题。该U54合作伙伴关系的目标是：1）研究酒精诱导的细胞病理学的分子机制。通过对酒精病理学分子机制进行综合和重点研究，该提案将为理解酒精发病率做出重要贡献，并将在NCCU创建有关酒精病理学的积极而成功的研究计划； 2）提供有关酒精病理学的学术教育。该提案中的教育工作将通过年度酒精研究日，通过BBRI，UNC BBRI举办的酒精研讨会系列，UNC Bowles酒精研究研讨会系列和NCCU FILLOSSHIPS for Bluncology and Indress for Bluchology and Indress for Bluchology and Intragence of Bluchology and Intragence and the New饮酒课程。最终，该提案将对酒精病理学机制进行，促进，支持和指导研究，并在NCCU-BBRI中创建一个精美而成功的酒精研究计划，该计划与UNC-ARC协同作用，以提高教育和发现。