Functional impact of dendritic cell phenotype in a mouse model of myositis

树突状细胞表型对肌炎小鼠模型的功能影响

• 批准号: 8188933
• 负责人: DANA P ASCHERMAN
• 金额: $ 10.23万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-03 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8188933
• 关键词: Address; Adjuvant; Adoptive Transfer; Antibody Formation; Antigen Targeting; Antigens; Autoantibodies; Autoimmune Diseases; Autoimmune Responses; Autoimmunity; Blocking Antibodies; Bypass; Bystander Suppression; Cardiomyopathies; Cell Culture Techniques; Cell physiology; Cells; Characteristics; Chemicals; Clinical Trials; Complement; Congenic Mice; Congenic Strain; Connective Tissue Diseases; Coupled; Dendritic Cells; Development; Disease; Disease model; Encephalomyelitis; Experimental Autoimmune Encephalomyelitis; Future; Histidine-tRNA Ligase; Human; Idiopathic Inflammatory Myopathies; Immune System Diseases; Immune Targeting; Immune response; Immunization; Immunologics; Immunosuppression; In Vitro; Inflammation; Inflammatory; Insulin-Dependent Diabetes Mellitus; Jo-1 antibody; Label; Ligase; Link; Lung; Lung Inflammation; Lymphocyte; Maintenance; Measurement; Mediating; Methods; Modeling; Mus; Muscle; Myosin ATPase; Myositis; Organ; Pathogenesis; Phenotype; Physiologic pulse; Population; Preparation; Primary biliary cirrhosis; Process; Production; Publishing; Pulmonary Fibrosis; Pyruvate Dehydrogenase Complex; Regimen; Regulatory T-Lymphocyte; Relative (related person); Reliance; Role; Spleen; Staining method; Stains; Stimulus; Structure of parenchyma of lung; Syndrome; System; T cell response; T-Cell Proliferation; T-Lymphocyte; Therapeutic; Tissues; Variant; Work; anergy; antigen challenge; base; clinically significant; comparative; conditioning; cytokine; human disease; immunoregulation; in vivo; insight; lymph nodes; mouse model; prevent; public health relevance; research study; response; therapeutic target

项目成果

Role of innate immunity in a murine model of histidyl-transfer RNA synthetase (Jo-1)-mediated myositis.

先天免疫在组氨酰转移 RNA 合成酶 (Jo-1) 介导的肌炎小鼠模型中的作用。

• 发表时间: 2011-02
• 作者: Soejima, Makoto;Kang, Eun Ha;Gu, Xinyan;Katsumata, Yasuhiro;Clemens, Paula R.;Ascherman, Dana P.
• 通讯作者: Ascherman, Dana P.