High resolution ultrasound imaging sensor array for biomedical imaging applicatio

用于生物医学成像应用的高分辨率超声成像传感器阵列

• 批准号: 8338250
• 负责人: Sang-Woo Seo
• 金额: $ 12.65万
• 依托单位: CITY COLLEGE OF NEW YORK
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-24 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8338250
• 关键词: Accounting; Acoustics; Arterial Fatty Streak; Arteries; Biological; Biomedical Engineering; Blood Vessels; Breast Microcalcification; Catheters; Cessation of life; Characteristics; Clinical; Collagen; Coronary Arteriosclerosis; Detection; Development; Diagnostic Procedure; Diagnostic Specificity; Disease; Event; Film; Goals; Heart; Hematoxylin and Eosin Staining Method; Human; Image; Imaging Device; Imaging Techniques; In Vitro; Laboratories; Light; Lipids; Magnetic Resonance Imaging; Mechanics; Methods; Microscope; Microscopic; Miniaturization; Morphology; Necrosis; Noise; Optics; Patients; Penetration; Polymers; Price; Research; Resolution; Risk; Roentgen Rays; Role; Rupture; Sampling; Scanning; Screening procedure; Signal Transduction; Spectrum Analysis; Staging; Staining method; Stains; Structure; Sudden Death; System; Technology; Thick; Three-Dimensional Image; Time; Tissues; Transducers; Translating; Ultrasonic Transducer; Ultrasonic wave; Ultrasonography; United States National Institutes of Health; acute coronary syndrome; base; bioimaging; cardiovascular risk factor; coronary artery calcification; cost; design; imaging modality; in vivo; microchip; molecular imaging; novel; photonics; pressure; sensor; tomography; tool

DESCRIPTION (provided by applicant): Rupture of the thin fibrous cap overlying the necrotic core of a vulnerable plaque is the principal cause of acute coronary syndrome. Fibrous cap rupture lies at the heart of reducing cardiovascular risk since it accounts for half of all coronar artery disease deaths and, moreover, occurs without warning in moderate-risk and asymptomatic patients. Of paramount importance to characterize and better understand the vulnerable plaque rupture mechanism is the insufficient resolution of clinically available imaging tools capable of provide high resolution morphology of the atheroma in real-time. Development of the proposed imaging sensor and its imaging method will permit identifying thin cap fibroatheromas (TCFA) and quantify coronary artery calcification with greater detail than with current imaging approaches, and will open the possibility of posing new fundamental questions related to the mechanism of TCFA rupture. Specific Aim 1 is to develop thin film acousto-optic transducer for conventional CMOS based camera systems. Based on the optical ultrasound detection method, the transducer will eliminate the requirement for many hundreds of active transducer channels, severe fabrication difficulties in electrical interconnection, and low transducer signal to noise ratio especially for the large imaging array size. Specific Aim 2 is to develop novel imaging acquisition method that allows the developed transducer with a conventional CMOS camera for high resolution ultrasound imaging. Finally, Specific Aim 3 is determine the ability of the developed acousto-optic ultrasound imaging system to identify microscopic tissue composition at high resolution in real-time. It will be used for both imaging of the morphology of the fibroatheroma and presence of microcalcifications as well as the tissue composition spectroscopy of fibrous cap, necrotic core and collagen content. The successful implementation of the proposed transducer and image acquisition method will allow an unprecedented high resolution ultrasound imaging that is impossible to achieve from conventional piezoelectric or capacitive micromachined ultrasound transducers. PUBLIC HEALTH RELEVANCE: More than half of 500,000 coronary artery disease deaths every year are due to the sudden asymptomatic rupture of vulnerable plaque. Available screening and diagnostic methods are insufficient to identify the victims before the event occurs. The proposed sensor array and imaging acquisition method will permit identifying thin cap fibroatheromas (TCFA) and quantify coronary artery calcification with greater detail than with current imaging approaches, and will open the possibility of posing new fundamental questions related to the mechanism of TCFA rupture.

描述（由申请人提供）：覆盖易损斑块坏死核心的薄纤维帽的破裂是急性冠状动脉综合征的主要原因。纤维帽破裂是降低心血管风险的核心，因为它占所有冠状动脉疾病死亡的一半，而且，在中等风险和无症状患者中，纤维帽破裂会毫无征兆地发生。对于表征和更好地理解易损斑块破裂机制至关重要的是，能够实时提供高分辨率粥样斑块形态的临床可用成像工具的分辨率不足。所提出的成像传感器及其成像方法的开发将允许识别薄帽纤维粥样斑块（TCFA）并比当前成像方法更详细地量化冠状动脉钙化，并将开启提出与 TCFA 破裂机制相关的新基本问题的可能性。具体目标 1 是为传统的基于 CMOS 的相机系统开发薄膜声光传感器。基于光学超声检测方法，该换能器将消除对数百个有源换能器通道的需求、电气互连中严重的制造困难以及低换能器信噪比，特别是对于大成像阵列尺寸。具体目标 2 是开发新颖的成像采集方法，允许所开发的传感器与传统 CMOS 相机一起进行高分辨率超声成像。最后，具体目标 3 是确定所开发的声光超声成像系统以高分辨率实时识别微观组织成分的能力。它将用于以下两种成像 纤维粥样斑块的形态和微钙化的存在以及纤维帽、坏死核心和胶原含量的组织成分光谱。所提出的换能器和图像采集方法的成功实施将实现前所未有的高分辨率超声成像，这是传统压电或电容微机械超声换能器无法实现的。 公众健康相关性：每年 50 万人因冠状动脉疾病死亡，其中一半以上是由于易损斑块突然无症状破裂造成的。现有的筛查和诊断方法不足以在事件发生之前识别受害者。所提出的传感器阵列和成像采集方法将允许识别薄帽纤维粥样斑块（TCFA）并比当前成像方法更详细地量化冠状动脉钙化，并将开启提出与 TCFA 破裂机制相关的新基本问题的可能性。