Health-related Quality of Life in Teens with Depression

抑郁症青少年的健康相关生活质量

• 批准号: 8259040
• 负责人: FRANCES L LYNCH
• 金额: $ 49.48万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8259040
• 关键词: Health; related; Quality; Life; Teens

DESCRIPTION (provided by applicant): Depression is one of the most common mental disorders among adolescents and has many negative consequences including impaired functioning and risk for future problems, (e.g., poor school performance, impaired relationships, substance abuse, and suicide). Mental health problems in youth often go unrecognized, and, even when they are recognized, most do not receive any treatment. Information on the burden of youth depression could show health system and public health policymakers the importance of teen depression as a health issue--they need accurate information to set priorities and fund programs to encourage youth depression treatment. Public health policymakers are increasingly using measures of health-related quality of life (HRQL) to compare the burden of disease between health conditions and HRQL is especially important in illnesses such as depression, where traditional measures of disease burden, such as mortality and morbidity, do not adequately capture the impact of the illness. Measures that rate the value of different health states, such as utility-based HRQL measures, are particularly helpful in demonstrating the burden of disease, analyzing the cost-effectiveness of new interventions, and setting priorities for clinical and reimbursement policies. No studies that have examined the use of utility-based HRQL measures in youth with depressive disorder. Our ultimate aim is to develop recommendations and guidelines for the assessment of HRQL in youth depression studies and clinical policymaking. This study will extend the understanding of HRQL in teens with depression by completing the following specific aims. First, we will evaluate the cross-sectional validity and reliability of several widely-used generic health status and utility-based HRQL measures in teens. Second, we will examine the sensitivity of the HRQL instruments in detecting clinically meaningful depression symptom change over 12 weeks following depression diagnosis. PUBLIC HEALTH RELEVANCE: Depression in teens is common and disabling. Currently available measures of the burden of depression in teens, such as symptom ratings, do not capture the full impact of depression on teens' lives. Improved measurement of the impact of depression on teen's quality of life would aid in evaluating new treatments and in setting public health policies to address teen depression.

描述（由申请人提供）：抑郁症是青少年中最常见的精神障碍之一，会产生许多负面后果，包括功能受损和未来出现问题的风险（例如，学业表现不佳、人际关系受损、药物滥用和自杀）。青少年的心理健康问题往往未被认识到，即使被认识到，大多数人也没有得到任何治疗。有关青少年抑郁症负担的信息可以向卫生系统和公共卫生政策制定者展示青少年抑郁症作为一个健康问题的重要性——他们需要准确的信息来确定优先事项并资助鼓励青少年抑郁症治疗的计划。公共卫生政策制定者越来越多地使用与健康相关的生活质量（HRQL）衡量标准来比较不同健康状况之间的疾病负担，而 HRQL 对于抑郁症等疾病尤其重要，传统的疾病负担衡量标准（例如死亡率和发病率）在抑郁症等疾病中尤为重要。没有充分认识到疾病的影响。评估不同健康状态价值的措施（例如基于效用的 HRQL 措施）特别有助于证明疾病负担、分析新干预措施的成本效益以及确定临床和报销政策的优先顺序。尚无研究检验基于效用的 HRQL 测量在患有抑郁症的青少年中的使用情况。我们的最终目标是为青年抑郁症研究和临床决策中的 HRQL 评估制定建议和指南。本研究将通过完成以下具体目标来扩展对抑郁症青少年 HRQL 的理解。首先，我们将评估青少年中几种广泛使用的一般健康状况和基于效用的 HRQL 测量的横截面有效性和可靠性。其次，我们将检查 HRQL 仪器在检测抑郁症诊断后 12 周内有临床意义的抑郁症状变化的敏感性。 公共卫生相关性：青少年抑郁症很常见，而且会造成残疾。目前可用的青少年抑郁负担衡量标准（例如症状评级）并不能全面反映抑郁对青少年生活的影响。更好地衡量抑郁症对青少年生活质量的影响将有助于评估新的治疗方法和制定解决青少年抑郁症的公共卫生政策。