Nutrition/Weight Loss, Exercise, Wellness Treatment for Bipolar Disorder

双相情感障碍的营养/减肥、运动、健康治疗

• 批准号: 8111032
• 负责人: Louisa Sylvia
• 金额: $ 17万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-15 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8111032
• 关键词: Address; Adherence; Admission activity; Area; Bipolar Disorder; Blinded; Body Weight decreased; Cardiovascular Diseases; Caring; Cause of Death; Clinical Trials; Comorbidity; Data Analyses; Development; Diabetes Mellitus; Diet Records; Diet and Nutrition; Disease; Evaluation; Exercise; Funding; Goals; Healthcare; Hospitals; Hyperlipidemia; Hypertension; Individual; Information Systems; Intervention; Manuals; Measures; Mediating; Mediator of activation protein; Medical; Mentored Patient-Oriented Research Career Development Award; Modality; Modeling; Moods; Morbidity - disease rate; National Institute of Mental Health; Obesity; Outcome; Participant; Patients; Pharmacological Treatment; Pilot Projects; Population; Provider; Psyche structure; Public Health; Quality of life; Questionnaires; Randomized; Randomized Controlled Trials; Reporting; Research; Research Project Grants; Research Training; Risk; Risk Factors; Statistical Models; Structure; Symptoms; Targeted Research; Testing; Time; Training; Visit; Weight Gain; base; behavioral health; burden of illness; cardiovascular disorder risk; cardiovascular risk factor; diet and exercise; flexibility; improved; improved functioning; innovation; meetings; mortality; multidisciplinary; non-compliance; novel; nutrition; physical conditioning; pilot trial; prevent; programs; psychosocial; research study; satisfaction; theories; therapy design; therapy development; treatment effect; treatment response

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in bipolar disorder, yet no empirically validated psychosocial interventions to manage risk factors for CVD in BD have been developed. The purpose of this Mentored Patient-Oriented Research Career Development Award is to develop and test the feasibility and acceptability of an integrated treatment to decrease CVD risk factors, while piloting its efficacy. The designed treatment integrates theories on Nutrition/weight loss strategies, Exercise interventions, and Wellness (NEW Tx) to address risk factors for CVD that co-occur with bipolar disorder. NEW Tx includes novel intervention strategies in each of these three modules, as well as modified and tailored empirically-supported strategies for bipolar disorder. The primary hypotheses are that NEW Tx will be feasible to deliver, acceptable to this population, and associated with improvements in CVD risk factors (i.e., Framingham Risk Score) over 20 weeks. Exploratory analyses will examine predictors of treatment response and the effect of NEW Tx on mood symptoms and overall functioning. Training will be sought in: 1) manual development and clinical trials; 2) diet and exercise interventions and assessment; and 3) sophisticated statistical models for longitudinal data analysis of clinical trials. The training and research plan supports the candidate's long-term goal of establishing a multidisciplinary program of innovative, personalized treatment research that targets the disproportionate medical burden of CVD in bipolar disorder, an important public health problem. Further research in this area has the potential to improve the lives of individuals with bipolar disorder, by reducing their medical admissions and encounters for treatment and management of comorbid CVD. PUBLIC HEALTH RELEVANCE: Cardiovascular disease is the leading cause of death among individuals with bipolar disorder. This research study develops a new psychosocial treatment for bipolar disorder to improve risk factors associated with cardiovascular disease, examines its feasibility and acceptability, and pilots its efficacy. This will impact public health by reducing medical visits and hospital admissions in this population as well as by potentially improving bipolar symptoms and functioning.

描述（由申请人提供）：心血管疾病（CVD）是双相情感障碍发病和死亡的主要原因，但尚未开发出经经验验证的社会心理干预措施来管理 BD 中 CVD 的危险因素。这项以患者为导向的研究职业发展奖的目的是开发和测试综合治疗的可行性和可接受性，以减少 CVD 危险因素，同时试点其疗效。设计的治疗方案整合了营养/减肥策略、运动干预和健康 (NEW Tx) 的理论，以解决与双相情感障碍同时发生的 CVD 危险因素。 NEW Tx 在这三个模块中均包括新颖的干预策略，以及经过修改和定制的双相情感障碍经验支持策略。主要假设是 NEW Tx 的实施是可行的，该人群可以接受，并且与 20 周内 CVD 风险因素（即弗雷明汉风险评分）的改善相关。探索性分析将检查治疗反应的预测因素以及 NEW Tx 对情绪症状和整体功能的影响。将寻求以下方面的培训： 1) 手册开发和临床试验； 2）饮食和运动干预及评估； 3）用于临床试验纵向数据分析的复杂统计模型。该培训和研究计划支持候选人建立一个创新、个性化治疗研究的多学科计划的长期目标，该计划针对双相情感障碍（一个重要的公共卫生问题）中心血管疾病造成的不成比例的医疗负担。该领域的进一步研究有可能通过减少双相情感障碍患者的入院率以及治疗和管理共病 CVD 的次数来改善他们的生活。 公共卫生相关性：心血管疾病是双相情感障碍患者死亡的主要原因。这项研究开发了一种新的双相情感障碍心理社会治疗方法，以改善与心血管疾病相关的危险因素，检验其可行性和可接受性，并试验其疗效。这将通过减少该人群的就诊和住院以及潜在改善双相情感障碍症状和功能来影响公共健康。