Focal HIFU Ablation of Prostate Cancer Using Advanced Ultrasound Guidance

使用先进超声引导进行前列腺癌局灶 HIFU 消融

• 批准号: 8447548
• 负责人: Ernest Joseph Feleppa
• 金额: $ 45.55万
• 依托单位: RIVERSIDE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-03 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8447548
• 关键词: 3-Dimensional; Ablation; Achievement; Address; Adverse effects; Biopsy; Brachytherapy; Cancerous; Classification; Clinical; Clinical Data; Cold Therapy; Computer software; Core Biopsy; Country; Cryosurgery; Data; Databases; Detection; Developed Countries; Development; Diagnostic; Dose; England; Excision; External Beam Radiation Therapy; Focused Ultrasound Therapy; Gland; Gold; Histocompatibility Testing; Histologic; Histology; Hospitals; Image; Image Guided Biopsy; Impotence; Investigation; Lesion; Location; London; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Malignant neoplasm of prostate; Marketing; Medical center; Methods; Modality; NIH Program Announcements; Nerve; Operative Surgical Procedures; Patients; Procedures; Prostate; Prostatic Diseases; Radiation; Radiation therapy; Rectal Fistula; Recurrence; Research; Research Institute; Salvage Therapy; Shapes; Spatial Distribution; Spectrum Analysis; System; Therapeutic; Time; Tissues; Ultrasonic Therapy; Ultrasonics; Ultrasonography; United States; United States National Institutes of Health; Universities; Urethral Obstruction; Urinary Incontinence; Validation; Virginia; base; cancer imaging; cancer therapy; college; cost; elastography; experience; high risk; imaging modality; improved; in vivo; instrument; men; novel strategies; prototype; public health relevance; quantum

DESCRIPTION (provided by applicant): Riverside Research Institute (RRI) and Focus Surgery, Inc. (FSI) propose an Academic-Industrial Partnership to develop and evaluate advanced ultrasonic means of guiding biopsies and treatment of prostate cancer, particularly treatment using focused ablative ultrasonic therapy. The proposed approach represents a very significant advancement in detection and treatment for this very common cancer of men in the United States and other developed countries worldwide. The proposed RRI-FSI Partnership specifically addresses NIH Program Announcement PAR-07-214, "Development and Validation of In-vivo Imaging Systems and Methods for Cancer Investigations." We seek to integrate advanced ultrasonic means of imaging prostate cancer that have been developed by RRI with a proven ultrasonic instrument that has been developed and manufactured by FSI for ablative treatment of prostate cancer. Conventional imaging methods cannot distinguish cancerous from non-cancerous prostate tissue, and consequently, all current biopsy and treatment methods essentially involve the entire gland. By emphasizing combined ultrasonic means of imaging cancer and treating it, we will overcome current imaging limitations, obviating the current need to ablate all tissue in the gland, and enabling treatment to be targeted to image cancerous tissue. This elegant integration of ultrasonic imaging and treatment modalities represents a novel approach to more-effectively treating only cancerous tissue in the prostate while reducing adverse side effects. By providing an effective means of delivering focal treatment, the proposed methods represent a quantum step forward in prostate-cancer management. The significance of these methods extends to biopsy guidance in general and to focal treatments of any type, including surgery, cryoablation, and radiation therapy. The proposed studies consist of three component efforts: 1) expanding our existing prostate-tissue data base and refining our tissue classification methods using transrectal 12-core biopsy histology gold standards; 2) evaluating targeting efficacy using transperineal template-guided saturation-biopsy histology gold standards; and 3) developing methods to identify viable cancer regions in radiation-treated patients who require salvage therapy. The proposed RRI-FSI Partnership will include internationally respected clinical collaborators who are experienced in the use of RRI's tissue-type imaging methods and FSI's ultrasonic ablation instrument. Our clinical collaborators are affiliated with the Virginia Mason Medical Center in Seattle, WA and the University College London Hospitals in London, England.

描述（由申请人提供）：Riverside Research Institute (RRI) 和 Focusurgery, Inc. (FSI) 提议建立学术-工业合作伙伴关系，以开发和评估引导活检和治疗前列腺癌的先进超声方法，特别是使用聚焦消融超声治疗治疗。所提出的方法代表了美国和世界其他发达国家在这种男性常见癌症的检测和治疗方面取得了非常重大的进步。拟议的 RRI-FSI 合作伙伴关系专门针对 NIH 计划公告 PAR-07-214，“用于癌症研究的体内成像系统和方法的开发和验证”。我们寻求将 RRI 开发的前列腺癌成像先进超声方法与 FSI 开发和制造的经过验证的超声仪器相结合，用于前列腺癌的消融治疗。传统的成像方法无法区分癌性前列腺组织和非癌性前列腺组织，因此，当前所有的活检和治疗方法基本上涉及整个腺体。通过强调癌症成像和治疗的联合超声方法，我们将克服当前的成像局限性，消除当前消融腺体中所有组织的需要，并使治疗能够针对癌组织进行成像。这种超声波成像和治疗方式的完美结合代表了一种新方法，可以更有效地仅治疗前列腺癌组织，同时减少不良副作用。通过提供一种有效的局部治疗方法，所提出的方法代表了前列腺癌管理的重大进步。这些方法的重要性延伸到一般活检指导和任何类型的局部治疗，包括手术、冷冻消融和放射治疗。拟议的研究包括三个组成部分：1）扩展我们现有的前列腺组织数据库，并使用经直肠 12 芯活检组织学金标准完善我们的组织分类方法； 2) 使用经会阴模板引导的饱和活检组织学金标准评估靶向功效； 3) 开发方法来识别需要挽救治疗的放射治疗患者的可行癌症区域。拟议的 RRI-FSI 合作伙伴关系将包括国际上受人尊敬的临床合作者，他们在使用 RRI 的组织型成像方法和 FSI 的超声消融仪器方面拥有丰富的经验。我们的临床合作者隶属于华盛顿州西雅图的弗吉尼亚梅森医疗中心和英国伦敦的伦敦大学学院医院。

项目成果

The 'Leucocyte Coping Capacity' test for identifying radiorecurrent prostate cancer: a pilot study.

用于识别放射性复发性前列腺癌的“白细胞应对能力”测试：一项试点研究。

• DOI: 10.1111/bju.16043
• 发表时间: 2023
• 期刊: BJU international
• 影响因子: 4.5
• 作者: Light,Alexander;Li,Xiaomeng;Otieno,Marjorie;Ahmed,HashimU;Shah,TaimurT
• 通讯作者: Shah,TaimurT

Magnetic Resonance Imaging and Targeted Biopsies Compared to Transperineal Mapping Biopsies Before Focal Ablation in Localised and Metastatic Recurrent Prostate Cancer After Radiotherapy.

• DOI: 10.1016/j.eururo.2022.02.022
• 发表时间: 2022-06
• 期刊: EUROPEAN UROLOGY
• 影响因子: 23.4
• 作者: Shah, Taimur T.;Kanthabalan, Abi;Otieno, Marjorie;Pavlou, Menelaos;Omar, Rumana;Adeleke, Sola;Giganti, Francesco;Brew-Graves, Chris;Williams, Norman R.;Grierson, Jack;Miah, Haroon;Emara, Amr;Haroon, Athar;Latifoltojar, Arash;Sidhu, Harbir;Clemente, Joey;Freeman, Alex;Orczyk, Clement;Nikapota, Ashok;Dudderidge, Tim;Hindley, Richard G.;Virdi, Jaspal;Arya, Manit;Payne, Heather;Mitra, Anita;Bomanji, Jamshed;Winkler, Mathias;Horan, Gail;Moore, Caroline M.;Emberton, Mark;Punwani, Shonit;Ahmed, Hashim U.
• 通讯作者: Ahmed, Hashim U.