Text Messaging to Improve Adherence to Oral Chemotherapy Agents

通过短信提高口服化疗药物的依从性

• 批准号: 8496241
• 负责人: Sandra Lee Spoelstra
• 金额: $ 46.46万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8496241
• 关键词: 21 year old; Academic Research Enhancement Awards; Adherence; Age; Antineoplastic Agents; Area; Behavioral; Cancer Center; Cancer Patient; Caring; Cellular Phone; Clinic; Clinic Visits; Clinical; Colon Carcinoma; Complex; Control Groups; Data; Diagnostic Neoplasm Staging; Discipline of Nursing; Disease; Dose; Effectiveness; Empirical Research; Enrollment; Environment; Equation; Funding; Goals; Grant; Health; Health Personnel; Home environment; Intervention; Interview; Life; Linear Models; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Marketing; Michigan; Nursing Students; Oncologist; Oral; Outcome; Participant; Patients; Pharmaceutical Preparations; Population; Process; Race; Randomized; Randomized Controlled Trials; Recruitment Activity; Regimen; Research; Research Project Grants; Self Care; Self Efficacy; Services; Severities; Students; Symptoms; Technology; Testing; Text; Therapeutic; Translations; Treatment Efficacy; Treatment Protocols; United States National Institutes of Health; Universities; base; cancer therapy; cancer type; career; chemotherapy; college; cost effective; graduate student; group intervention; improved; innovation; interest; malignant breast neoplasm; malignant mouth neoplasm; member; novel; pill; prospective; public health relevance; randomized trial; satisfaction; sex; statistics; symptom management; therapy development; treatment as usual; undergraduate student

DESCRIPTION (provided by applicant): The purpose of this Academic Research Enhancement Award proposal is to conduct a small-scale, health- related research project on text messages to improve adherence to oral chemotherapy agents. Michigan State University College of Nursing (MSU-CON) has not been a major recipient of National Institute of Health grant funding. As a result, the overall objectiveof this proposal is to strengthen the research environment in the College of Nursing so that it can develop into a significant health-related scientific research enterprise. This project would involv undergraduate and graduate students and, thus, generate student interest in research as a career. The importance of the research planned for this proposal is as follows. More than 50 oral chemotherapy agents in pill form are currently on the market, with projections that in 3 years, 25% of cancer treatments will be delivered in pill form. There are many associated benefits of oral agents, such as convenience, avoidance of clinic visits, and reduced impact on daily activities. For oral agents to achieve a - therapeutically effective level for cancer treatmet, patients must strictly adhere to the regimen. Adherence to oral cancer agents is often less than 80%, which may be inadequate for treating the cancer. To further complicate this, nearly 75% of those with cancer also have comorbid conditions with self-care management responsibilities, which may create barriers to oral agent adherence. To date, empirical research in the area of improving adherence to oral agents is underdeveloped. The goal of this research is to improve adherence to oral chemotherapy agents through a technology-based strategy: tailored short message service (SMS) text messages. This 10 week, two group, prospective randomized controlled trial will enroll 75 patients (50 in the intervention group and 25 in the control group) from three cancer centers to examine the feasibility, acceptability, and satisfaction with a three week, tailored, text message intervention for oral agent adherence. Descriptive statistics, generalized linear modeling, and generalized estimating equations will be used for analysis. In this proposal, preliminary data will be collected to examine efficacy of the text message intervention to promote adherence to oral agents. Data will then be used to further inform the development of an intervention to improve adherence to oral agents for an R01 application to conduct a larger randomized trial to test this innovative intervention. This study can have a transformative impact on oral agent adherence by developing a technology-based strategy to promote adherence among the increasing number of cancer patients who receive their cancer treatment in pill form. This type of novel intervention also has the potential to transform and impact many other ill populations that require adherence to a medication regimen. Furthermore, this proposal involves numerous nursing students, allowing them to be fully functioning members of a team and engaging them in the research process. This application will strengthen the research environment at MSU- CON so that it can develop into a significant health-related scientific research enterprise.

描述（由申请人提供）： 该学术研究增强奖提案的目的是开展一个小规模的、与健康相关的短信研究项目，以提高口服化疗药物的依从性。密歇根州立大学护理学院 (MSU-CON) 并不是美国国立卫生研究院拨款资助的主要接受者。因此，本提案的总体目标是加强护理学院的研究环境，使其发展成为一个重要的健康相关科研事业。该项目将涉及本科生和研究生，从而激发学生对研究作为职业的兴趣。本提案计划的研究的重要性如下。目前市场上有超过 50 种药丸形式的口服化疗药物，预计 3 年内，25% 的癌症治疗将以药丸形式提供。口服药物有许多相关的好处，例如方便、避免就诊以及减少对日常活动的影响。为了使口服药物达到癌症治疗的有效水平，患者必须严格遵守治疗方案。口腔癌药物的依从性通常低于 80%，这可能不足以治疗癌症。更复杂的是，近 75% 的癌症患者还患有需要自我护理管理责任的合并症，这可能会对口服药物的依从性造成障碍。迄今为止，提高口服药物依从性领域的实证研究尚不完善。这项研究的目标是通过基于技术的策略提高口服化疗药物的依从性：定制短信服务 (SMS) 文本消息。这项为期 10 周的两组前瞻性随机对照试验将招募来自三个癌症中心的 75 名患者（干预组 50 名，对照组 25 名），以检查为期三周的定制短信的可行性、可接受性和满意度口服药物依从性的干预。将使用描述性统计、广义线性模型和广义估计方程进行分析。在该提案中，将收集初步数据来检查短信干预对促进口服药物依从性的有效性。然后，数据将用于进一步指导干预措施的开发，以提高 R01 应用口服药物的依从性，以进行更大规模的随机试验来测试这种创新干预措施。这项研究可以通过开发一种基于技术的策略来促进越来越多接受药丸形式癌症治疗的癌症患者的依从性，从而对口服药物的依从性产生变革性影响。这种新型干预措施还有可能改变和影响许多其他需要遵守药物治疗方案的患病人群。此外，该提案涉及众多护理专业学生，使他们能够成为团队中充分发挥作用的成员，并让他们参与研究过程。该应用程序将加强 MSU-CON 的研究环境，使其能够发展成为一个重要的健康相关科学研究企业。