2013 Stress Proteins in Growth, Development & Disease Gordon Research Conference

2013 生长、发育中的应激蛋白

• 批准号: 8597489
• 负责人: JUDITH FRYDMAN
• 金额: $ 3.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8597489
• 关键词: Affect; African American; Aging; Alzheimer' s Disease; Area; Biochemical; Biological Models; Biology; Cattle; Cell Proliferation; Cells; Cellular biology; Collaborations; Commit; Communities; Country; Creutzfeldt-Jakob Syndrome; Data; Defect; Development; Devices; Disease; Ensure; Environment; Equilibrium; Europe; Evaluation; Gender; Gene Activation; Gene Expression; Generations; Genes; Growth and Development function; Health; Heat shock proteins; Homeostasis; Human; Huntington Disease; Infection; Inflammation; Intervention; Lead; Light; Link; Longevity; Maintenance; Metabolism; Michigan; Molecular; Molecular Chaperones; Names; Neurodegenerative Disorders; Oral; Organism; Oxidative Stress; Parkinson Disease; Participant; Physiological; Physiology; Plants; Play; Postdoctoral Fellow; Protein Conformation; Protein Dynamics; Protein-Folding Disease; Proteins; Proteome; Radiation; Regulation; Request for Applications; Research; Research Personnel; Resort; Role; Schedule; Science; Scientist; Series; Shapes; Signal Transduction; Site; Snow; Sodium Chloride; Stress; Structure; System; Techniques; Temperature; Time; Ubiquitin; Underrepresented Minority; Universities; Vermont; Water Stress; Woman; Work; abstracting; age group; age related; base; biological adaptation to stress; graduate student; human disease; meetings; microbial; multicatalytic endopeptidase complex; nervous system disorder; polyglutamine; polypeptide; posters; preference; prion-based; programs; protein folding; protein function; public health relevance; research and development; stress protein; symposium; transcription factor

DESCRIPTION (provided by applicant): The cellular proteome is constantly exposed to a wide variety of toxic stresses. These include external stresses, such as elevated temperatures, radiation damage and pharmacological agents as well as physiological stresses encountered during cellular proliferation, differentiation, inflammation and aging. In all organisms, inductionof the stress response is essential for the maintenance of protein homeostasis and modulation of the stress response plays a critical role in life-span regulation and aging-related diseases such as Alzheimer's, Parkinson's and Huntington's disease. The 2013 Gordon Conference on "Stress Proteins in Growth, Development & Disease" is shaping up to be one of the most exciting and important meetings in this research area. It will highlight the many cutting edge advances in the field, emphasizing a broad range of topics, including exciting developments related to stress sensing, signaling, and gene expression, diseases of protein folding and conformation, roles of stress genes in metabolism, growth and development, stress gene modulation of infection and pathophysiological states, the cell biology of stress, and the roles of stress in aging. This conference, which is the seventh in this series, will be held July 7th-12th at the Mount Snow Resort in West Dover, Vermont. The chair of this meeting is Dr. Judith Frydman (Stanford University, Stanford, CA) and the co-chair is Dr. Ursula Jakob (University of Michigan, Ann Arbor, MI). Thus far, 34 internationally recognized speakers have committed to attending and speaking at the 2013 meeting, including 9 women and one African- American. Moreover, significant effort will be undertaken to increase the diversity of meeting attendees, to bring more scientists into the stress protein field, and to catalyze the formation of new collaborations. To this end, the schedule has been prepared so that 10 speaking slots will be chosen from abstracts submitted for poster presentations, and preference will be given to younger scientists and to those from under-represented groups. The meeting schedule will also be prepared to ensure that new and emerging themes in stress biology and different model systems are equally represented. In addition, meeting attendance will be "capped" at 200 to facilitate effective interactions and discussions. The formal scientific program together with more informal discussions will enhance the dissemination of new information and the formation of new collaborations, which are invaluable for deeper understanding of the versatile roles of stress proteins in human health, aging and disease.

描述（由申请人提供）：细胞蛋白质组不断暴露于多种有毒应力。这些包括外部应力，例如升高温度，辐射损伤和药理学剂以及在细胞增殖，分化，炎症和衰老期间遇到的生理压力。在所有生物体中，诱导压力反应对于维持蛋白质稳态至关重要，而压力反应的调节在生命跨度调节和与衰老有关的疾病（如阿尔茨海默氏症，帕金森氏症和亨廷顿氏病）中起着至关重要的作用。 2013年戈登关于“增长，发展与疾病中的压力蛋白”的会议正在塑造，成为该研究领域中最令人兴奋和最重要的会议之一。它将强调该领域的许多最前沿进步，强调了广泛的主题，包括与压力感应，信号传导和基因表达相关的令人兴奋的发展，蛋白质折叠和构象的疾病，压力基因在代谢，生长和发育中的作用，生长和发育中的作用，压力基因的压力基因调节和病理学状态和病理生物学的压力，压力和压力的细胞生物，以及敏捷的敏感性。这次会议是本系列的第七届会议，将于7月7日至12日在佛蒙特州西多佛的山雪山度假村举行。这次会议的主席是加利福尼亚州斯坦福大学的朱迪思·弗雷德曼（Judith Frydman）博士（斯坦福大学），联合主席是密歇根大学，密歇根大学，密歇根州安阿伯市，密歇根大学）。到目前为止，有34位国际认可的发言人承诺在2013年的会议上参加和讲话，其中包括9名妇女和一名非裔美国人。此外，将付出巨大的努力，以增加与会者的多样性，以带来更多 科学家进入压力蛋白领域，并促进新合作的形成。为此，准备时间表已经准备好，以便从提交海报演示的摘要中选择10个口语插槽，并将优先考虑年轻的科学家和代表性不足的群体的偏好。会议时间表还准备好确保压力生物学和不同模型系统中的新主题和不同的主题同样代表。此外，会议的出席率将在200时“限制”，以促进有效的互动和讨论。正式的科学计划以及更非正式的讨论将增强新信息的传播和新合作的形成，这对于更深入地理解压力蛋白在人类健康，衰老和疾病中的多功能作用是无价的。