Malaria Research Training in South India

印度南部的疟疾研究培训

• 批准号: 8109997
• 负责人: CHANNE D GOWDA
• 金额: $ 13.89万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8109997
• 关键词: 6H,8H-3,4-dihydropyrimido(4,5-c)(1,2)oxazin-7-one; Applications Grants; Benign; Cities; Clinical; Doctor of Philosophy; Drug resistance; Educational workshop; Fostering; Goals; Health; India; Infection; Instruction; Laboratory Research; Malaria; Parasites; Pregnant Women; Principal Investigator; Recruitment Activity; Research; Research Personnel; Research Project Grants; Research Training; Resources; Students; Training; Vivax Malaria; Work; cytokine; epidemiology study; experience; field study; programs; response; symposium

Program Director/Principal Investigator (Last, First, Middle): GOWDA, Channe D PROJECT SUMMARY (See instructions): Although P. vivax infection has been commonly considered to be benign, in recent years it has been associated with severe malaria with significant fatalities. Like in other parts of the world, P. vivax malaha infection predominates in India, including South India. Despite the enormity of P. vivax associated malaria health burden, research efforts to understand the pathophysiological and immunological basis for P. vivax severe malaria have been meager. So far very little or no malaria research, especially on P. vivax, is being undertaken in South India, particularly in the Karnataka State. This Is due to lack of resources and scarcity of skilled and experienced malaria investigators. The overall goal of this grant application is to train young and meritorious PhD students from India on P. vivax malaria in Mangalore city of Southwestern Karnataka. The training will be given by a group of expert Indian and US investigators recruited to this program. Four PhD students will be trained on P. vivax malaria so that they become expert investigators and are able to take up independent studies on aspects of malaria that are relevant to the study region. The training will be imparted through field studies, laboratory research work, and by organizing symposia and workshops. Specific research aspects for training include: (i) to study the epidemiology of malaria infection and parasite drug resistance, (ii) to gain information on the clinical presentations of P. vivax malaria and cytokine responses, and (iii) to understand the impact of P. vivax infection in pregnant women. The long-term goals are to support and foster research projects taken up by trainees as independent investigators, conducting research on malaria in the Southwestern region of India.

项目总监/首席研究员（最后，第一，中间）：Gowda，Channe D 项目摘要（请参阅说明）： 尽管普通疟原虫感染通常被认为是良性的，但近年来，它与严重的疟疾有重大死亡有关。像世界其他地区一样，毒素疟原虫感染在印度包括印度在内的印度占主导地位。尽管体内疟原虫的健康负担很大，但研究的研究工作旨在了解病理生理和免疫学的严重疟疾的病理生理和免疫学基础仍然很少。到目前为止，在印度南部，特别是在卡纳塔克邦进行的疟疾研究，尤其是关于Vivax的疟疾研究。这是由于缺乏资源和熟练和经验丰富的疟疾调查人员的稀缺性。该赠款申请的总体目标是培训来自印度西南卡纳塔克邦市芒格洛尔市的P. Vivax疟疾的年轻和有功的博士生。 培训将由一群印度专家和美国调查人员进行该计划。四名博士学位学生将接受疟原虫疟疾的培训，以便他们成为专家研究人员，并能够对与研究区域相关的疟疾方面进行独立研究。培训将通过现场研究，实验室研究工作以及组织研讨会和研讨会来进行。 培训的具体研究方面包括：（i）研究疟疾感染和寄生虫耐药性的流行病学，（ii）以获取有关维瓦克斯疟疾和细胞因子反应的临床表现的信息，以及（iii）以了解维瓦克斯感染对孕妇的影响。长期目标是支持和培养受训者作为独立研究人员进行的研究项目，进行 印度西南地区疟疾的研究。