STUDIES OF WTR DYNAMICS BY T1RHO AND T2RHO MRI IN ACUTE CEREBRAL ISCHEMIA RAT

急性脑缺血大鼠T1RHO和T2RHO MRI WTR动力学研究

• 批准号: 8170484
• 负责人: Risto A Kauppinen
• 金额: $ 0.64万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170484
• 关键词: Acute; Brain; Brain Ischemia; Cerebral Ischemia; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Edema; Funding; Grant; Infarction; Institution; Magnetic Resonance Imaging; Process; Rattus; Relaxation; Research; Research Personnel; Resources; Site; Source; Stroke; Tissues; United States National Institutes of Health; Water; Work; insight; macromolecule; tissue processing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rotating frame relaxation MRI contrast, T1rho and T2rho, are thought to provide sensitive indicators of tissue changes in hyperacute stroke. In this work, we are investigating the changes in T1rho and T2rho MRI of infarcting brain, and have recently shown that the changes in hyperacute stroke reflect an increase in the free water pool size, decreased tumbling of the water molecules associated with macromolecules, and increased water exchange between free and macromolecular sites. These findings are consistent with vasogenic edema, destructive processes and tissue acidification. This research is providing new insights into the physico-chemical processes occurring in brain ischemia

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 旋转框架松弛 MRI 对比 T1rho 和 T2rho 被认为可以提供超急性中风组织变化的敏感指标。在这项工作中，我们正在研究梗死脑的 T1rho 和 T2rho MRI 的变化，最近发现超急性卒中的变化反映了自由水池大小的增加、与大分子相关的水分子翻滚的减少以及与大分子相关的水分子翻滚的增加。自由位点和大分子位点之间的水交换。这些发现与血管源性水肿、破坏性过程和组织酸化一致。这项研究为脑缺血中发生的物理化学过程提供了新的见解