YOUNG ADULTS WITH ADDICTION: IMPULSIVITY, BRAIN DYSFUNCTION AND RECOVERY

成瘾的年轻人：冲动、脑功能障碍和恢复

• 批准号: 8170438
• 负责人: SHEILA Mary SPECKER
• 金额: $ 0.32万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170438
• 关键词: Abstinence; Admission activity; Age; Amphetamine Abuse; Amphetamine Dependence; Brain; Brain imaging; Brain scan; Cocaine; Computer Retrieval of Information on Scientific Projects Database; Computers; Fellowship; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Gender; Goals; Grant; Impulsivity; Institution; MRI Scans; Measures; Neurobiology; Neurocognition; Neurocognitive; Outcome; Participant; Process; Psychostimulant dependence; Recovery; Recruitment Activity; Research; Research Personnel; Resources; Scanning; Socioeconomic Status; Source; Spectrum Analysis; Testing; Time; United States National Institutes of Health; Variant; Youth; addiction; base; behavior measurement; executive function; gamma-Aminobutyric Acid; neurocognitive test; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will study 15 young adults (ages 18 to 25) who are currently in treatment for cocaine or stimulant dependence at Hazelden Fellowship Club (as well as 15 controls). We will study neurobiological abnormalities, neurocognition and impulsivity particularly as they are associated with the recovery process. Specifically, subjects will undergo neurocognitive testing and tasks measuring impulsivity at two time points: at the beginning of their stay and at approximately 60 days to assess brain recovery through the active process of treatment and abstinence. Both self-rating scales of impulsivity (Barratt Impulsivity Scale) and computer tasks measuring executive functioning will be done. Brain imaging scans would also be completed at these two time points for similar reasons. The brain imaging portion of the study will consist of MRI scans and GABA spectroscopy which will be conducted soon after admission to Fellowship club and at three months. Although the participants would essentially act as their own controls we also would recruit healthy controls matched on age, gender, socioeconomic status and thus would allow comparisons on these tests with normal controls. The same measures and scanning could be done with controls including a repeat scan at three months to measure normal variation in GABA. The goal of this project is to examine whether youth with cocaine or amphetamine dependence (who are in treatment) are more impulsive than controls, as well as to determine the underlying brain abnormalities that exist in people with cocaine or amphetamine abuse as measured by fMRI and GABA spectroscopy. Based on the results of the brain scans, we hope to determine whether brain recovery (e.g. amelioration of abnormalities) occurs in these subjects with addiction over a 2-month period of being in a recovery setting. Through the neurocognitive testing, we hope to determine whether these neurocognitive and behavioral measures of impulsivity are correlated with altered GABA levels. Finally, the researcher will examine if any of the changes observed on behavioral measures or the fMRI are associated with recovery outcomes.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目将研究 15 名目前正在 Hazelden Fellowship Club 接受可卡因或兴奋剂依赖治疗的年轻人（18 至 25 岁）（以及 15 名对照组）。我们将研究神经生物学异常、神经认知和冲动，特别是它们与恢复过程相关的情况。具体来说，受试者将在两个时间点接受神经认知测试和测量冲动的任务：在住院开始时和大约 60 天时，以评估通过主动治疗和禁欲过程的大脑恢复情况。冲动自评量表（巴勒特冲动量表）和衡量执行功能的计算机任务都将完成。出于类似的原因，脑成像扫描也将在这两个时间点完成。 该研究的脑成像部分将包括 MRI 扫描和 GABA 光谱，将在进入联谊俱乐部后不久和三个月后进行。尽管参与者本质上将充当自己的对照，但我们也会招募与年龄、性别、社会经济地位相匹配的健康对照，从而允许将这些测试与正常对照进行比较。可以对对照进行相同的测量和扫描，包括三个月时重复扫描以测量 GABA 的正常变化。 该项目的目标是检查可卡因或安非他明依赖的青少年（正在接受治疗）是否比对照组更容易冲动，并确定可卡因或安非他明滥用者中存在的潜在大脑异常（通过功能磁共振成像和GABA 光谱。根据脑部扫描的结果，我们希望确定这些成瘾受试者在康复环境中的两个月内是否出现大脑恢复（例如异常的改善）。通过神经认知测试，我们希望确定这些冲动的神经认知和行为测量是否与 GABA 水平的改变相关。最后，研究人员将检查行为测量或功能磁共振成像观察到的任何变化是否与恢复结果相关。