Biomedical Researcher Development Program in TMJD and Orofacial Pain

颞下颌关节紊乱病和口面部疼痛生物医学研究员发展计划

• 批准号: 8353144
• 负责人: LUDA DIATCHENKO
• 金额: $ 27.31万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8353144
• 关键词: Acute Pain; Address; Award; Basic Science; Behavioral; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Complex; Development; Diagnosis; Disease; Environment; Environmental Risk Factor; Epidemiology; Fostering; Future; Genetic; Goals; Grooming; Health Policy; Health Services; Individual; K-Series Research Career Programs; Knowledge; Lead; Mentors; Methods; Mission; Molecular Genetics; National Institute of Dental and Craniofacial Research; Nature; North Carolina; Orofacial Pain; Pain Disorder; Pain Research; Preparation; Program Development; Research; Research Personnel; Research Training; SECTM1 gene; Scholarship; School Dentistry; Science; Scientist; Series; Temporomandibular Joint Disorders; Therapeutic Intervention; Training Support; Translational Research; Universities; biobehavior; biopsychosocial; career; career development; chronic pain; cohort; improved; investigator training; next generation; novel strategies; programs; response; skills; social

DESCRIPTION (provided by applicant): Temporomandibular Joint Disorders (TMJD) and Orofacial Pain (OFP) are complex and multi-factorial pain disorders involving genetic, social, cultural, biobehavioral, and environmental factors. To effectively manage these conditions, multi-and inter-disciplinary teams of TMJD and OFP basic and clinical researchers are needed to adequately address the multi-factorial nature of these conditions. This document represents an institutional response from the University of North Carolina at Chapel Hill (UNC-CH) School of Dentistry's (SOD) Center for Neurosensory Disorders (CNSD) to NIDCR PAR-11-289: Institutional Career Development Award for Enhancing Research Capacity in Temporomandibular Joint Disorders and Orofacial Pain (K12). The purpose of this proposed Biomedical Researcher Development Scholarship (BRDS) program is to develop a cohort of successful and independent basic, clinical and translational research scholars who can lead multi- disciplinary research teams to apply novel approaches to TMJD and OFP research that will improve the understanding of these disorders and lead to more effective methods of diagnosis and treatment. Our program embraces the full spectrum of basic, translational and clinical research including mechanisms of acute and chronic pain, therapeutic intervention, clinical trials, epidemiology, social, and behavioral clinical research related to TMJD, OFP and related comorbid pain disorders. A strong focus on the biopsychosocial and molecular genetic mechanisms that contribute to TMJD and OFP will be emphasized. BRD scholars will have the opportunity to carry out supervised biomedical, epidemiological, health services/health policy, or clinical research with the primary objective of developing or enhancing multi-disciplinary collaborative research skills and knowledge in preparation for an independent research career relevant to the mission of the NIDCR. This career development award proposes to enhance the research capacity of scholars in the field of TMJD and OFP research by achieving the following objectives: 1) To attract and engage junior or new basic and clinical investigators trained in sciences relevant to TMJD and OFP who are from diverse biomedical backgrounds into the field of TMJD and OFP research; 2) To mentor and nurture these research scholars and equip them with the necessary knowledge and skills to pursue independent research careers in TMJD and OFP; 3) To integrate the research scholars into a multi- and inter-disciplinary research environment that will foster the development of collaborative scientific advancement as well as enhance individual skills and expertise; 4) To assist BRD scholars with the development of K08, K23 or R series awards, or with other mechanisms of research training support and career development; 5) To groom these research scholars to become future leaders of multi- and inter-disciplinary collaborative research teams; and 6) To continue to support and mentor scholars following completion of their BRDS. Our goal is to create a new cadre of multi-disciplinary and highly interactive scientists who can serve as the next generation of TMJD and OFP research leaders. PUBLIC HEALTH RELEVANCE: The purpose of this proposed Biomedical Researcher Development Scholarship (BRDS) program is to develop successful and independent basic, clinical and translational research scholars who can lead multi-disciplinary research teams to apply novel approaches to TMJD and OFP research that will improve the understanding of these disorders and lead to more effective methods of diagnosis and treatment.

描述（由申请人提供）：颞下颌关节疾病（TMJD）和口面疼痛（OFP）是复杂而多因素的疼痛障碍，涉及遗传，社会，文化，生物行为和环境因素。为了有效地管理这些条件，需要充分解决这些条件的多因素性质，以解决TMJD和OFP基本和临床研究人员的多学科跨学科团队。该文件代表了北卡罗来纳大学教堂山（UNC-CH）牙科学院（SOD）神经感觉障碍中心（CNSD）对NIDCR PAR-11-289：机构职业发展奖，以增强颞肢体关节疾病和Orofacacial疼痛（K12）的机构职业发展奖。这项提出的生物医学研究人员发展奖学金（BRDS）计划的目的是开发一系列成功，独立的基础，临床和转化研究学者，他们可以领导多学科研究团队将新颖的方法应用于TMJD和OFP研究，以提高对这些疾病的理解并提高诊断和治疗的有效方法。我们的计划涵盖了基本，转化和临床研究的全部范围，包括急性和慢性疼痛的机制，治疗性干预，临床试验，流行病学，社会和行为临床研究，与TMJD，OFP和相关性疼痛疾病有关。将强调对有助于TMJD和OFP的生物心理社会和分子遗传机制的重点。 BRD学者将有机会进行监督的生物医学，流行病学，卫生服务/卫生政策或临床研究，其主要目的是开发或增强多学科的合作研究技能和知识，以准备与NIDCR的使命相关的独立研究职业。该职业发展奖建议通过实现以下目标来提高学者在TMJD和OFP研究领域的研究能力：1）吸引和参与与TMJD和OFP有关的科学培训的初级或新的基本和临床研究人员，这些研究人员来自与TMJD和OFP研究领域的不同生物医学背景有关的科学； 2）指导和培养这些研究学者，并为他们提供必要的知识和技能，从而从事TMJD和OFP的独立研究职业； 3）将研究学者整合到多学科的研究环境中，以促进协作科学进步的发展，并增强个人技能和专业知识； 4）协助BRD学者开发K08，K23或R系列奖，或其他研究培训支持和职业发展机制； 5）培养这些研究学者，成为多学科合作研究团队的未来领导者； 6）在BRD完成后继续支持和指导学者。我们的目标是创建一个新的多学科和高度互动科学家的干部，他们可以作为下一代TMJD和OFP研究领导者。 公共卫生相关性：该提议的生物医学研究人员发展奖学金（BRDS）计划的目的是开发成功且独立的基础，临床和转化研究学者，他们可以领导多学科研究团队将新颖的方法应用于TMJD和OFP研究，以改善对这些疾病的理解，并引起更有效的诊断和治疗方法。