Metabolomic profiling in the prediction of Gestational Diabetes Mellitus

代谢组学分析在妊娠糖尿病预测中的应用

基本信息

批准号：
8536804
负责人：
Rhonda Bentley-Lewis
金额：
$ 15.19万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8536804
关键词：
Aromatic Amino Acids Behavior Therapy Biological Markers Birth trauma Carbohydrates Cesarean section Cohort Studies Development Diabetes Mellitus Diabetes prevention Diagnostic Discipline of obstetrics Discrimination Early identification Emerging Technologies Enrollment Epidemic Ethnic Origin Family history of First Pregnancy Trimester Functional disorder General Hospitals Gestational Diabetes Incidence Intervention Intervention Studies Investigation Isoleucine Leucine Massachusetts Metformin Modeling Mothers Neonatal Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Overweight Placebos Population Population Study Pregnancy Prevalence Prevention strategy Public Health Race Recording of previous events Risk Risk Factors System Technology Tyrosine Valine Weight Woman advanced maternal age biological systems cohort diabetes prevention program effective therapy improved insulin sensitivity lifestyle intervention metabolomics modifiable risk novel offspring prevent therapy design weight loss intervention

项目摘要

DESCRIPTION (provided by applicant): Gestational diabetes mellitus (GDM) complicates approximately 7% of pregnancies in the U.S. However, the epidemics of obesity and diabetes, as well as revised GDM diagnostic criteria, are dramatically increasing the prevalence of GDM, as high as 18% of pregnancies according to some estimates. This increasing prevalence is noteworthy because of the concomitant risk for adverse sequelae, not only in the peripartum period, such as increased rates of caesarean section delivery and neonatal birth injury, but also subsequent to pregnancy, including increased risk for type 2 diabetes mellitus (T2DM) for both mother and offspring. Early identification of women at increased risk for GDM would provide the opportunity for the development of targeted GDM and T2DM risk prevention strategies. Our proposal capitalizes on our expertise in emerging technologies, as well as our existing study populations, to further characterize women at increased risk for developing GDM and T2DM. Our Specific Aim 1 will examine a cohort of women followed during pregnancy for the development of GDM. Our Specific Aims 2-4 will examine the cohort of women within the Diabetes Prevention Program (DPP) with a history of GDM for the development of T2DM while examining the effects of study intervention and race on the outcome.

描述（由申请人提供）：妊娠糖尿病（GDM）使大约7％的怀孕复杂化，但是，肥胖和糖尿病的流行病以及GDM的诊断标准急剧增加了GDM的诊断标准，该标准增加了GDM的患病率高，高于GDM的患病率高，达到了GDM的患病率高。根据一些估计，怀孕18％。值得注意的是，这种增加的患病率不仅存在不良后遗症的风险，不仅在围角度时期，例如剖腹产分娩率提高和新生儿出生损伤的速度，还包括怀孕后，包括增加2型糖尿病风险（T2DM ）对于母亲和后代。对GDM风险增加的妇女的早期确定将为有针对性的GDM和T2DM风险预防策略提供机会。我们的提案利用了我们在新兴技术方面的专业知识以及现有的研究人群，以进一步表征女性发展GDM和T2DM风险增加的女性。我们的具体目标1将检查怀孕期间的一群女性以发展GDM。我们的具体目的2-4将研究预防糖尿病预防计划（DPP）中的女性队列，其中GDM的历史用于开发T2DM，同时研究研究干预和种族对结果的影响。